Intratesticular prepubertal‑type mature teratoma in an infant: A case report and mini‑review of the literature

Fakhralddin,Saman S.; Ali,Rawa M.; Omar,Sami Saleem; Ali,Rebaz M.; Mohammed,Bryar O.; Karim,Rawa Amin; Abdullah,Hiwa O.; Mohammed,Karukh K.; Mohammed,Shvan H.; Ahmed,Sasan M.; Kakamad,Fahmi H.

doi:10.3892/mi.2024.177

September-October 2024 Volume 4 Issue 5

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September-October 2024 Volume 4 Issue 5

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Case Report Open Access

Intratesticular prepubertal‑type mature teratoma in an infant: A case report and mini‑review of the literature

Authors:
- Saman S. Fakhralddin
- Rawa M. Ali
- Sami Saleem Omar
- Rebaz M. Ali
- Bryar O. Mohammed
- Rawa Amin Karim
- Hiwa O. Abdullah
- Karukh K. Mohammed
- Shvan H. Mohammed
- Sasan M. Ahmed
- Fahmi H. Kakamad
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Affiliations: College of Medicine, University of Sulaimani, Sulaymaniyah, Kurdistan 46001, Iraq, Department of Scientific Affairs, Smart Health Tower, Sulaymaniyah, Kurdistan 46001, Iraq, Rizgary Oncology Center, Erbil, Kurdistan 44001, Iraq, Smart Health Tower (Raparin Branch), Rania, Sulaymaniyah, Kurdistan 46001, Iraq, Department of Urology, Sulaymaniyah Surgical Teaching Hospital, Sulaymaniyah, Kurdistan 46001, Iraq, Kscien Organization for Scientific Research, Sulaymaniyah, Kurdistan 46001, Iraq
Published online on: July 15, 2024 https://doi.org/10.3892/mi.2024.177
Article Number: 53
Copyright : © Fakhralddin et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Testicular tumors are rare in children, representing a small percentage of pediatric solid tumors, with an incidence of 2 cases per 100,000 males. Teratomas, which are the most prevalent tumors in infants, may manifest in mature, immature, or malignant forms. While mature teratomas are typically found in the abdomen, intratesticular prepubertal‑type teratomas in infants are infrequent. The present study describes the case of an infant with an intratesticular mature teratoma. A 6‑month‑old male infant presented with right‑sided scrotal swelling, which was noted by his parents. There was no family history of similar conditions, and an investigation of his medical history did not reveal any notable findings. A physical examination revealed a non‑reducible, solid mass indistinguishable from the right testicle, with no signs of inflammation or systemic symptoms. A scrotal sonography confirmed a large intratesticular cyst. The levels of α‑fetoprotein and β‑human chorionic gonadotropin were normal. Surgical tumor enucleation was performed, and the histopathological examination revealed a benign, prepubertal‑type teratoma composed entirely of mature elements. Surgical intervention is commonly used for the management of benign testicular tumors in pediatric patients, including prepubertal teratomas. This approach demonstrates an excellent prognosis as it does not elevate the likelihood of recurrence. Prepubertal‑type teratomas have rarely been reported in the infantile testis. They may present as a solid mass indistinguishable from the testicle, with no signs of inflammation.

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1	Li Z, Zhang W, Song H and Sun N: Testis-preserving tumor enucleation is applicable in children with immature testicular teratoma. Urol Int. 105:27–30. 2021.PubMed/NCBI View Article : Google Scholar
2	Mingomataj E, Krasniqi M, Dedushi K, Sergeevich KA, Kust D, Qadir AA, Abdullah AS, Ahmed MK and Fatah GM: Cancer publications in one year (2023): A cross-sectional study. Barw Med J. 2:3–11. 2024.
3	Hasegawa T, Maeda K, Kamata N and Okita Y: A case of immature teratoma originating in intra-abdominal undescended testis in a 3-month-old infant. Pediatr Surg Int. 22:570–572. 2006.PubMed/NCBI View Article : Google Scholar
4	Tanaka N, Yoneda A and Fukuzawa M: Mature teratoma arising from an intraabdominal testis in a 2-month-old boy: Case report and review of intraabdominal testicular tumors in children. J Pediatr Surg. 44:E15–E18. 2009.PubMed/NCBI View Article : Google Scholar
5	Sabir WN, Ahmed SM, Hasan KM, Mohammed BA, Kareem HO, Najmadden ZB, Abdalla BA, Salih RQ, Mohammed SH, Kakamad FH and Azaldeen HA: Giant sacrococcygeal teratoma in an infant: A case report with a literature review. Ann Med Surg (Lond). 85:5666–5669. 2023.PubMed/NCBI View Article : Google Scholar
6	Terenziani M, D'Angelo P, Inserra A, Boldrini R, Bisogno G, Babbo GL, Conte M, Dall' Igna P, De Pasquale MD, Indolfi P, et al: Mature and immature teratoma: A report from the second Italian pediatric study. Pediatr Blood Cancer. 62:1202–1208. 2015.PubMed/NCBI View Article : Google Scholar
7	Moritoki Y, Mizuno K, Kato T, Hamamoto S, Hattori H, Ito Y, Saitoh S, Yasui T and Hayashi Y: Testicular teratoma demanded in-depth pathological exploration to rule out malignancy: A pediatric case report. IJU Case Rep. 2:115–117. 2019.PubMed/NCBI View Article : Google Scholar
8	Abdullah HO, Abdalla BA, Kakamad FH, Ahmed JO, Baba HO, Hassan MN, Bapir R, Rahim HM, Omar DA, Kakamad SH, et al: Predatory publishing lists: A review on the ongoing battle against fraudulent actions. Barw Med J. 2:26–30. 2024.
9	Prasad S, Nassar M, Azzam AY, García-Muro-San José F, Jamee M, Sliman RK, Evola G, Mustafa AM, Abdullah HO, Abdalla B, et al: CaReL guidelines: A consensus-based guideline on case reports and literature review (CaReL). Barw Med J. 2:13–19. 2024.
10	Mukai M, Takamatsu H, Noguchi H and Tahara H: Intra-abdominal testis with mature teratoma. Pediatr Surg Int. 13:204–205. 1998.PubMed/NCBI View Article : Google Scholar
11	Yam B, Georgiou NA, Khullar P, Coren CV and Katz DS: Radiology-pathology conference: Mature teratoma arising from an intra-abdominal undescended testis in a 7-month-old infant. Clin Imaging. 34:466–471. 2010.PubMed/NCBI View Article : Google Scholar
12	Amin MB: WHO classification of tumours. Urinary and Male Genital Tumours. International Agency for Research on Cancer, Lyon, 2022.
13	Doi O, Itoh F and Aoyama K: Mature teratoma arising in intraabdominal undescended testis in an infant with previous inguinal exploration: Case report and review of intraabdominal testicular tumors in children. J Pediatr Surg. 37:1236–1238. 2002.PubMed/NCBI View Article : Google Scholar
14	Pramanik DD, Bhatnagar V, Subbarao KC, Sharma MC, Agarwala S and Gupta AK: Antenatally detected mature teratoma in an undescended testis. Eur J Pediatr Surg. 21:209–210. 2011.PubMed/NCBI View Article : Google Scholar
15	Taskinen S, Fagerholm R, Aronniemi J, Rintala R and Taskinen M: Testicular tumors in children and adolescents. J Pediatr Urol. 4:134–137. 2008.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Intratesticular prepubertal‑type mature teratoma in an infant: A case report and mini‑review of the literature

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