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Article Open Access

Early detection of resistance to dual antiplatelet therapy in patients who have undergone percutaneous coronary intervention using the VerifyNow test and associated factors

  • Authors:
    • Song Giang Tran
    • Thi Kieu My Tran
    • Tan Sang Nguyen
    • Minh Phuong Vu
  • View Affiliations / Copyright

    Affiliations: Vietnam National Heart Institute, Bach Mai Hospital, Hanoi 11519, Vietnam, Department of Hematology, Hanoi Medical University, Hanoi 11521, Vietnam
    Copyright: © Tran et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 56
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    Published online on: July 18, 2024
       https://doi.org/10.3892/mi.2024.180
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Abstract

Resistance to dual antiplatelet therapy (DAPT), including aspirin and clopidogrel, in patients who have undergone percutaneous coronary intervention (PCI) leads to the inability to prevent thrombotic complications. The present study aimed to evaluate early resistance to aspirin and clopidogrel in patients following PCI using the VerifyNow test and associated factors. A total of 50 patients diagnosed with acute coronary syndromes (ACS) who underwent emergency PCI and received DAPT were recruited in the present study. The detection of resistance to aspirin and clopidogrel was performed using the VerifyNow system. Resistance to aspirin was determined with VerifyNow Aspirin >550 aspirin reaction units (ARU). Resistance to clopidogrel was determined with VerifyNow P2Y12 >208 P2Y12 reaction units (PRU). The resistance rate to aspirin was 14%, while the resistance rate to clopidogrel was higher, at 34%. There were 2 patients with resistance to aspirin and clopidogrel (4%). Univariable logistic regression analysis revealed that diabetes, the use of β‑blockers, and low levels of hemoglobin and hematocrit were associated with resistance to clopidogrel. Following multivariable logistic regression analysis, only the use of β‑blockers was truly associated with resistance to clopidogrel. On the whole, the results of the present study may also prove to be helpful in the selection of therapeutic drugs for patients undergoing PCI and who are diagnosed with ACS.
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Spandidos Publications style
Tran S, Tran T, Nguyen T and Vu M: Early detection of resistance to dual antiplatelet therapy in patients who have undergone percutaneous coronary intervention using the VerifyNow test and associated factors. Med Int 4: 56, 2024.
APA
Tran, S., Tran, T., Nguyen, T., & Vu, M. (2024). Early detection of resistance to dual antiplatelet therapy in patients who have undergone percutaneous coronary intervention using the VerifyNow test and associated factors. Medicine International, 4, 56. https://doi.org/10.3892/mi.2024.180
MLA
Tran, S., Tran, T., Nguyen, T., Vu, M."Early detection of resistance to dual antiplatelet therapy in patients who have undergone percutaneous coronary intervention using the VerifyNow test and associated factors". Medicine International 4.6 (2024): 56.
Chicago
Tran, S., Tran, T., Nguyen, T., Vu, M."Early detection of resistance to dual antiplatelet therapy in patients who have undergone percutaneous coronary intervention using the VerifyNow test and associated factors". Medicine International 4, no. 6 (2024): 56. https://doi.org/10.3892/mi.2024.180
Copy and paste a formatted citation
x
Spandidos Publications style
Tran S, Tran T, Nguyen T and Vu M: Early detection of resistance to dual antiplatelet therapy in patients who have undergone percutaneous coronary intervention using the VerifyNow test and associated factors. Med Int 4: 56, 2024.
APA
Tran, S., Tran, T., Nguyen, T., & Vu, M. (2024). Early detection of resistance to dual antiplatelet therapy in patients who have undergone percutaneous coronary intervention using the VerifyNow test and associated factors. Medicine International, 4, 56. https://doi.org/10.3892/mi.2024.180
MLA
Tran, S., Tran, T., Nguyen, T., Vu, M."Early detection of resistance to dual antiplatelet therapy in patients who have undergone percutaneous coronary intervention using the VerifyNow test and associated factors". Medicine International 4.6 (2024): 56.
Chicago
Tran, S., Tran, T., Nguyen, T., Vu, M."Early detection of resistance to dual antiplatelet therapy in patients who have undergone percutaneous coronary intervention using the VerifyNow test and associated factors". Medicine International 4, no. 6 (2024): 56. https://doi.org/10.3892/mi.2024.180
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