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Clinical and genetic analysis of children with glucose transporter type 1 deficiency syndrome

  • Authors:
    • Hao Qian
    • Guohuan Ying
    • Haifeng Xu
    • Shangyu Wang
    • Bing Wu
    • Xin Wang
    • Hongdan Qi
    • Mingying He
    • M. Jalal Ud Din
    • Tingting Huang
    • Yimei Wu
    • Gang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China, Department of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China
    Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 57
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    Published online on: July 19, 2024
       https://doi.org/10.3892/mi.2024.181
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Abstract

Glucose transporter type 1 deficiency syndrome (GLUT1‑DS) is a rare metabolic encephalopathy with a wide variety of clinical phenotypes. In the present study, 15 patients diagnosed with GLUT1‑DS were selected, all of whom had obvious clinical manifestations and complete genetic testing. Their clinical data and genetic reports were collated. All patients were provided with a ketogenic diet (KD) and an improvement in their symptoms was observed during a follow‑up period of up to 1 year. The results revealed that the 15 cases had clinical symptoms, such as convulsions or dyskinesia. Although none had a cerebrospinal fluid/glucose ratio <0.4, the genetic report revealed that all had the solute carrier family 2 member 1 gene variant, and their clinical symptoms basically improved following the use of the KD. GLUT1‑DS is a genetic metabolic disease that causes a series of neurological symptoms due to glucose metabolism disorders in the brain. Low glucose levels in cerebrospinal fluid and genetic testing are key diagnostic criteria, and the KD is a highly effective treatment option. By summarizing and analyzing patients with GLUT1‑DS, summarizing clinical characteristics and expanding their gene profile, the findings of the present study may be of clinical significance for the early recognition and diagnosis of the disease, so as to conduct early treatment and shorten the duration of brain energy deficiency. This is of utmost importance for improving the prognosis and quality of life of affected children.
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1 

Raichle ME and Gusnard DA: Appraising the brain's energy budget. Proc Natl Acad Sci USA. 99:10237–10239. 2002.PubMed/NCBI View Article : Google Scholar

2 

Tang M and Monani UR: Glut1 deficiency syndrome: New and emerging insights into a prototypical brain energy failure disorder. Neurosci Insights. 16(26331055211011507)2021.PubMed/NCBI View Article : Google Scholar

3 

Seidner G, Alvarez MG, Yeh JI, O'Driscoll KR, Klepper J, Stump TS, Wang D, Spinner NB, Birnbaum MJ and De Vivo DC: GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood-brain barrier hexose carrier. Nat Genet. 18:188–191. 1998.PubMed/NCBI View Article : Google Scholar

4 

De Vivo DC, Trifiletti RR, Jacobson RI, Ronen GM, Behmand RA and Harik SI: Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglycorrhachia, seizures, and developmental delay. N Engl J Med. 325:703–709. 1991.PubMed/NCBI View Article : Google Scholar

5 

Soto-Insuga V, López RG, Losada-Del Pozo R, Rodrigo-Moreno M, Cayuelas EM, Giráldez BG, Díaz-Gómez E, Sánchez-Martín G, García LO and Serratosa JM: Grupo Español de Genética de las Epilepsias de la Infancia (GEGEI). Glut1 deficiency is a rare but treatable cause of childhood absence epilepsy with atypical features. Epilepsy Res. 154:39–41. 2019.PubMed/NCBI View Article : Google Scholar

6 

Pawlik W, Okulewicz P, Pawlik J and Krzywińska-Zdeb E: Diagnostic and clinical manifestation differences of glucose transporter type 1 deficiency syndrome in a family with SLC2A1 Gene Mutation. Int J Environ Res Public Health. 19(3279)2022.PubMed/NCBI View Article : Google Scholar

7 

Klepper J, Akman C, Armeno M, Auvin S, Cervenka M, Cross HJ, De Giorgis V, Della Marina A, Engelstad K, Heussinger N, et al: Glut1 Deficiency Syndrome (Glut1DS): State of the art in 2020 and recommendations of the international Glut1DS study group. Epilepsia Open. 5:354–365. 2020.PubMed/NCBI View Article : Google Scholar

8 

Koch H and Weber YG: The glucose transporter type 1 (Glut1) syndromes. Epilepsy Behav. 91:90–93. 2019.PubMed/NCBI View Article : Google Scholar

9 

De Giorgis V and Veggiotti P: GLUT1 deficiency syndrome 2013: Current state of the art. Seizure. 22:803–811. 2013.PubMed/NCBI View Article : Google Scholar

10 

Gburek-Augustat J, Heinze A, Abou Jamra R and Merkenschlager A: Hemiplegic Migraine in Glut1 deficiency syndrome and paroxysmal dyskinesia at ketogenic diet induction: Case report and literature review. Mov Disord Clin Pract. 7:965–970. 2020.PubMed/NCBI View Article : Google Scholar

11 

Schwantje M, Verhagen LM, van Hasselt PM and Fuchs SA: Glucose transporter type 1 deficiency syndrome and the ketogenic diet. J Inherit Metab Dis. 43:216–222. 2020.PubMed/NCBI View Article : Google Scholar

12 

Larsen J, Johannesen KM, Ek J, Tang S, Marini C, Blichfeldt S, Kibaek M, von Spiczak S, Weckhuysen S, Frangu M, et al: The role of SLC2A1 mutations in myoclonic astatic epilepsy and absence epilepsy, and the estimated frequency of GLUT1 deficiency syndrome. Epilepsia. 56:e203–e208. 2015.PubMed/NCBI View Article : Google Scholar

13 

Hully M, Vuillaumier-Barrot S, Le Bizec C, Boddaert N, Kaminska A, Lascelles K, de Lonlay P, Cances C, des Portes V, Roubertie A, et al: From splitting GLUT1 deficiency syndromes to overlapping phenotypes. Eur J Med Genet. 58:443–454. 2015.PubMed/NCBI View Article : Google Scholar

14 

Gras D, Cousin C, Kappeler C, Fung CW, Auvin S, Essid N, Chung BH, Da Costa L, Hainque E, Luton MP, et al: A simple blood test expedites the diagnosis of glucose transporter type 1 deficiency syndrome. Ann Neurol. 82:133–138. 2017.PubMed/NCBI View Article : Google Scholar

15 

Mauri A, Duse A, Palm G, Previtali R, Bova SM, Olivotto S, Benedetti S, Coscia F, Veggiotti P and Cereda C: Molecular Genetics of GLUT1DS Italian pediatric cohort: 10 novel disease-related variants and structural analysis. Int J Mol Sci. 23(13560)2022.PubMed/NCBI View Article : Google Scholar

16 

Ito Y, Takahashi S, Kagitani-Shimono K, Natsume J, Yanagihara K, Fujii T and Oguni H: Nationwide survey of glucose transporter-1 deficiency syndrome (GLUT-1DS) in Japan. Brain Dev. 37:780–789. 2015.PubMed/NCBI View Article : Google Scholar

17 

Ji XN, Xu CJ, Gao ZJ, Chen SH, Xu KM and Chen Q: Glucose transporter 1 deficiency syndrome: Features of movement disorders, diagnosis and treatment. Zhongguo Dang Dai Er Ke Za Zhi. 20:209–213. 2018.PubMed/NCBI View Article : Google Scholar : (In Chinese).

18 

Kumagai AK, Dwyer KJ and Pardridge WM: Differential glycosylation of the GLUT1 glucose transporter in brain capillaries and choroid plexus. Biochim Biophys Acta. 1193:24–30. 1994.PubMed/NCBI View Article : Google Scholar

19 

Mueckler M, Caruso C, Baldwin SA, Panico M, Blench I, Morris HR, Allard WJ, Lienhard GE and Lodish HF: Sequence and structure of a human glucose transporter. Science. 229:941–945. 1985.PubMed/NCBI View Article : Google Scholar

20 

Willemsen MA, Vissers LE, Verbeek MM, van Bon BW, Geuer S, Gilissen C, Klepper J, Kwint MP, Leen WG, Pennings M, et al: Upstream SLC2A1 translation initiation causes GLUT1 deficiency syndrome. Eur J Hum Genet. 25:771–774. 2017.PubMed/NCBI View Article : Google Scholar

21 

Raja M and Kinne RK: Pathogenic mutations causing glucose transport defects in GLUT1 transporter: The role of intermolecular forces in protein structure-function. Biophys Chem. 200-201:9–17. 2015.PubMed/NCBI View Article : Google Scholar

22 

Hewson S, Brunga L, Ojeda MF, Imhof E, Patel J, Zak M, Donner EJ, Kobayashi J, Salomons GS and Mercimek-Andrews S: Prevalence of genetic disorders and GLUT1 deficiency in a ketogenic diet clinic. Can J Neurol Sci. 45:93–96. 2018.PubMed/NCBI View Article : Google Scholar

23 

Suls A, Mullen SA, Weber YG, Verhaert K, Ceulemans B, Guerrini R, Wuttke TV, Salvo-Vargas A, Deprez L, Claes LR, et al: Early-onset absence epilepsy caused by mutations in the glucose transporter GLUT1. Ann Neurol. 66:415–419. 2009.PubMed/NCBI View Article : Google Scholar

24 

Leary LD, Wang D, Nordli DR Jr, Engelstad K and De Vivo DC: Seizure characterization and electroencephalographic features in Glut-1 deficiency syndrome. Epilepsia. 44:701–707. 2003.PubMed/NCBI View Article : Google Scholar

25 

Wolking S, Becker F, Bast T, Wiemer-Kruel A, Mayer T, Lerche H and Weber YG: Focal epilepsy in glucose transporter type 1 (Glut1) defects: Case reports and a review of literature. J Neurol. 261:1881–1886. 2014.PubMed/NCBI View Article : Google Scholar

26 

Peeraer A, Damiano JA, Bellows ST, Scheffer IE, Berkovic SF, Mullen SA and Hildebrand MS: Evaluation of GLUT1 variation in non-acquired focal epilepsy. Epilepsy Res. 133:54–57. 2017.PubMed/NCBI View Article : Google Scholar

27 

Tchapyjnikov D and Mikati MA: Acetazolamide-responsive episodic ataxia without baseline deficits or seizures secondary to GLUT1 Deficiency: A case report and review of the literature. Neurologist. 23:17–18. 2018.PubMed/NCBI View Article : Google Scholar

28 

Pons R, Collins A, Rotstein M, Engelstad K and De Vivo DC: The spectrum of movement disorders in Glut-1 deficiency. Mov Disord. 25:275–281. 2010.PubMed/NCBI View Article : Google Scholar

29 

Ramm-Pettersen A, Stabell KE, Nakken KO and Selmer KK: Does ketogenic diet improve cognitive function in patients with GLUT1-DS? A 6- to 17-month follow-up study. Epilepsy Behav. 39:111–115. 2014.PubMed/NCBI View Article : Google Scholar

30 

Gramer G, Wolf NI, Vater D, Bast T, Santer R, Kamsteeg EJ, Wevers RA and Ebinger F: Glucose transporter-1 (GLUT1) deficiency syndrome: Diagnosis and treatment in late childhood. Neuropediatrics. 43:168–171. 2012.PubMed/NCBI View Article : Google Scholar

31 

Ramm-Pettersen A, Nakken KO, Haavardsholm KC and Selmer KK: GLUT1-deficiency syndrome: Report of a four-generation Norwegian family with a mild phenotype. Epilepsy Behav. 70(Pt A):1–4. 2017.PubMed/NCBI View Article : Google Scholar

32 

Castellotti B, Ragona F, Freri E, Solazzi R, Ciardullo S, Tricomi G, Venerando A, Salis B, Canafoglia L, Villani F, et al: Screening of SLC2A1 in a large cohort of patients suspected for Glut1 deficiency syndrome: Identification of novel variants and associated phenotypes. J Neurol. 266:1439–1448. 2019.PubMed/NCBI View Article : Google Scholar

33 

Hashimoto N, Kagitani-Shimono K, Sakai N, Otomo T, Tominaga K, Nabatame S, Mogami Y, Takahashi Y, Imai K, Yanagihara K, et al: SLC2A1 gene analysis of Japanese patients with glucose transporter 1 deficiency syndrome. J Hum Genet. 56:846–851. 2011.PubMed/NCBI View Article : Google Scholar

34 

Hu Q, Shen Y, Su T, Liu Y and Xu S: Clinical and genetic characteristics of chinese children with GLUT1 deficiency syndrome: Case report and literature review. Front Genet. 12(734481)2021.PubMed/NCBI View Article : Google Scholar

35 

Hao J, Kelly DI, Su J and Pascual JM: Clinical aspects of glucose transporter type 1 deficiency: Information from a global registry. JAMA Neurol. 74:727–732. 2017.PubMed/NCBI View Article : Google Scholar

36 

Yang H, Wang D, Engelstad K, Bagay L, Wei Y, Rotstein M, Aggarwal V, Levy B, Ma L, Chung WK and De Vivo DC: Glut1 deficiency syndrome and erythrocyte glucose uptake assay. Ann Neurol. 70:996–1005. 2011.PubMed/NCBI View Article : Google Scholar

37 

De Giorgis V, Masnada S, Varesio C, Chiappedi MA, Zanaboni M, Pasca L, Filippini M, Macasaet JA, Valente M, Ferraris C, et al: Overall cognitive profiles in patients with GLUT1 Deficiency Syndrome. Brain Behav. 9(e01224)2019.PubMed/NCBI View Article : Google Scholar

38 

Yu M, Miao J, Lv Y, Wang X, Zhang W, Shao N and Meng H: A challenging diagnosis of atypical glut1-DS: A case report and literature review. Front Neurol. 11(549331)2021.PubMed/NCBI View Article : Google Scholar

39 

Leen WG, Klepper J, Verbeek MM, Leferink M, Hofste T, van Engelen BG, Wevers RA, Arthur T, Bahi-Buisson N, Ballhausen D, et al: Glucose transporter-1 deficiency syndrome: The expanding clinical and genetic spectrum of a treatable disorder. Brain. 133(Pt 3):655–670. 2010.PubMed/NCBI View Article : Google Scholar

40 

Yu LF, Zhang YQ, Duan J, Ni Y, Gong XY, Lu ZY, Liao JX, Lu XP, Shi ZN, Lei MF, et al: Clinical characteristics and ketogenic diet therapy of glucose transporter type 1 deficiency syndrome in children: A multicenter clinical study. Zhonghua Er Ke Za Zhi. 58:881–886. 2020.PubMed/NCBI View Article : Google Scholar : (In Chinese).

41 

Amalou S, Gras D, Ilea A, Greneche MO, Francois L, Bellavoine V, Delanoe C and Auvin S: Use of modified Atkins diet in glucose transporter type 1 deficiency syndrome. Dev Med Child Neurol. 58:1193–1199. 2016.PubMed/NCBI View Article : Google Scholar

42 

Ohshiro-Sasaki A, Shimbo H, Takano K, Wada T and Osaka H: A three-year-old boy with glucose transporter type 1 deficiency syndrome presenting with episodic ataxia. Pediatr Neurol. 50:99–100. 2014.PubMed/NCBI View Article : Google Scholar

43 

Haberlandt E, Karall D, Jud V, Baumgartner SS, Zotter S, Rostasy K, Baumann M and Scholl-Buergi S: Glucose transporter type 1 deficiency syndrome effectively treated with modified Atkins diet. Neuropediatrics. 45:117–119. 2014.PubMed/NCBI View Article : Google Scholar

44 

Nakamura S, Muramatsu SI, Takino N, Ito M, Jimbo EF, Shimazaki K, Onaka T, Ohtsuki S, Terasaki T, Yamagata T and Osaka H: Gene therapy for Glut1-deficient mouse using an adeno-associated virus vector with the human intrinsic GLUT1 promoter. J Gene Med. 20(e3013)2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Qian H, Ying G, Xu H, Wang S, Wu B, Wang X, Qi H, He M, Ud Din M, Huang T, Huang T, et al: Clinical and genetic analysis of children with glucose transporter type 1 deficiency syndrome. Med Int 4: 57, 2024.
APA
Qian, H., Ying, G., Xu, H., Wang, S., Wu, B., Wang, X. ... Zhang, G. (2024). Clinical and genetic analysis of children with glucose transporter type 1 deficiency syndrome. Medicine International, 4, 57. https://doi.org/10.3892/mi.2024.181
MLA
Qian, H., Ying, G., Xu, H., Wang, S., Wu, B., Wang, X., Qi, H., He, M., Ud Din, M., Huang, T., Wu, Y., Zhang, G."Clinical and genetic analysis of children with glucose transporter type 1 deficiency syndrome". Medicine International 4.6 (2024): 57.
Chicago
Qian, H., Ying, G., Xu, H., Wang, S., Wu, B., Wang, X., Qi, H., He, M., Ud Din, M., Huang, T., Wu, Y., Zhang, G."Clinical and genetic analysis of children with glucose transporter type 1 deficiency syndrome". Medicine International 4, no. 6 (2024): 57. https://doi.org/10.3892/mi.2024.181
Copy and paste a formatted citation
x
Spandidos Publications style
Qian H, Ying G, Xu H, Wang S, Wu B, Wang X, Qi H, He M, Ud Din M, Huang T, Huang T, et al: Clinical and genetic analysis of children with glucose transporter type 1 deficiency syndrome. Med Int 4: 57, 2024.
APA
Qian, H., Ying, G., Xu, H., Wang, S., Wu, B., Wang, X. ... Zhang, G. (2024). Clinical and genetic analysis of children with glucose transporter type 1 deficiency syndrome. Medicine International, 4, 57. https://doi.org/10.3892/mi.2024.181
MLA
Qian, H., Ying, G., Xu, H., Wang, S., Wu, B., Wang, X., Qi, H., He, M., Ud Din, M., Huang, T., Wu, Y., Zhang, G."Clinical and genetic analysis of children with glucose transporter type 1 deficiency syndrome". Medicine International 4.6 (2024): 57.
Chicago
Qian, H., Ying, G., Xu, H., Wang, S., Wu, B., Wang, X., Qi, H., He, M., Ud Din, M., Huang, T., Wu, Y., Zhang, G."Clinical and genetic analysis of children with glucose transporter type 1 deficiency syndrome". Medicine International 4, no. 6 (2024): 57. https://doi.org/10.3892/mi.2024.181
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