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From sound waves to molecular and cellular mechanisms: Understanding noise‑induced hearing loss and pioneering preventive approaches (Review)

  • Authors:
    • Pinelopi Samara
    • Michail Athanasopoulos
    • Nikolaos Markatos
    • Ioannis Athanasopoulos
  • View Affiliations / Copyright

    Affiliations: Children's Oncology Unit ‘Marianna V. Vardinoyannis‑ELPIDA’, Aghia Sophia Children's Hospital, 11527 Athens, Greece, Otolaryngology‑Head and Neck Surgery, Athens Pediatric Center, 15125 Athens, Greece
    Copyright: © Samara et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 60
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    Published online on: July 30, 2024
       https://doi.org/10.3892/mi.2024.184
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Abstract

Noise‑induced hearing loss (NIHL) is a significant and urgent global public health concern, arising from prolonged exposure to elevated levels of noise. This auditory impairment harms delicate inner ear structures, particularly the essential hair cells transmitting auditory signals to the brain. Recognized by the World Health Organization as a major contributor to worldwide hearing loss, NIHL requires a comprehensive examination of its molecular and cellular mechanisms. Animal models emerge as indispensable tools for unraveling these intricacies, allowing researchers to simulate and study the impact of noise exposure on auditory structures, shedding light on the interplay of oxidative stress, inflammation and immune responses‑crucial factors in NIHL progression. The present review focuses on elucidating the molecular mechanisms of NIHL, with a specific emphasis on findings derived from animal models, alongside the exploration of thorough preventive strategies, including protective measures and probing potential interventions. Understanding the molecular underpinnings not only provides insight into targeted treatment approaches, but also unlocks pathways for exploring and implementing preventive actions. This approach not only deepens the current comprehension of NIHL, but also has the potential to influence the shaping of public health policies, offering a nuanced perspective on this prevalent auditory disorder.
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Spandidos Publications style
Samara P, Athanasopoulos M, Markatos N and Athanasopoulos I: From sound waves to molecular and cellular mechanisms: Understanding noise‑induced hearing loss and pioneering preventive approaches (Review). Med Int 4: 60, 2024.
APA
Samara, P., Athanasopoulos, M., Markatos, N., & Athanasopoulos, I. (2024). From sound waves to molecular and cellular mechanisms: Understanding noise‑induced hearing loss and pioneering preventive approaches (Review). Medicine International, 4, 60. https://doi.org/10.3892/mi.2024.184
MLA
Samara, P., Athanasopoulos, M., Markatos, N., Athanasopoulos, I."From sound waves to molecular and cellular mechanisms: Understanding noise‑induced hearing loss and pioneering preventive approaches (Review)". Medicine International 4.6 (2024): 60.
Chicago
Samara, P., Athanasopoulos, M., Markatos, N., Athanasopoulos, I."From sound waves to molecular and cellular mechanisms: Understanding noise‑induced hearing loss and pioneering preventive approaches (Review)". Medicine International 4, no. 6 (2024): 60. https://doi.org/10.3892/mi.2024.184
Copy and paste a formatted citation
x
Spandidos Publications style
Samara P, Athanasopoulos M, Markatos N and Athanasopoulos I: From sound waves to molecular and cellular mechanisms: Understanding noise‑induced hearing loss and pioneering preventive approaches (Review). Med Int 4: 60, 2024.
APA
Samara, P., Athanasopoulos, M., Markatos, N., & Athanasopoulos, I. (2024). From sound waves to molecular and cellular mechanisms: Understanding noise‑induced hearing loss and pioneering preventive approaches (Review). Medicine International, 4, 60. https://doi.org/10.3892/mi.2024.184
MLA
Samara, P., Athanasopoulos, M., Markatos, N., Athanasopoulos, I."From sound waves to molecular and cellular mechanisms: Understanding noise‑induced hearing loss and pioneering preventive approaches (Review)". Medicine International 4.6 (2024): 60.
Chicago
Samara, P., Athanasopoulos, M., Markatos, N., Athanasopoulos, I."From sound waves to molecular and cellular mechanisms: Understanding noise‑induced hearing loss and pioneering preventive approaches (Review)". Medicine International 4, no. 6 (2024): 60. https://doi.org/10.3892/mi.2024.184
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