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Print ISSN: 2754-3242 Online ISSN: 2754-1304
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January-February 2025 Volume 5 Issue 1

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Serum β‑hCG as a prognostic marker for colorectal adenocarcinoma in women of reproductive age: A case report and literature review

  • Authors:
    • Changlin Gong
    • Fnu Vikash
    • Juliet Silberstein
    • Sherrie White
    • Donald Kotler
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA, Department of Pathology, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA, Division of Gastroenterology, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 8
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    Published online on: November 18, 2024
       https://doi.org/10.3892/mi.2024.207
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Abstract

Serological and histological examinations have unveiled the presence of free β subunit of human chorionic gonadotropin (β‑hCG) in some cases of colorectal adenocarcinoma. The present study describes an unusual case of a young female patient afflicted with rapidly advancing adenocarcinoma of the sigmoid colon. Despite the absence of pregnancy indications on an ultrasound and curettage, a notable elevation of β‑hCG was detected in the serum, alongside positive staining in the tumor tissue. β‑hCG‑positive colorectal adenocarcinoma is associated with a lower survival rate, tissue invasion and metastases, as well as a good response to chemotherapy, compared with β‑hCG‑negative counterparts. Moreover, the serum β‑hCG level decreases with treatment. Thus, β‑hCG may serve as a tumor marker for response monitoring. However, further studies are required to investigate the potential benefit of routine serological and histological β‑hCG studies in patients with colorectal adenocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Gong C, Vikash F, Silberstein J, White S and Kotler D: Serum β‑hCG as a prognostic marker for colorectal adenocarcinoma in women of reproductive age: A case report and literature review. Med Int 5: 8, 2025.
APA
Gong, C., Vikash, F., Silberstein, J., White, S., & Kotler, D. (2025). Serum β‑hCG as a prognostic marker for colorectal adenocarcinoma in women of reproductive age: A case report and literature review. Medicine International, 5, 8. https://doi.org/10.3892/mi.2024.207
MLA
Gong, C., Vikash, F., Silberstein, J., White, S., Kotler, D."Serum β‑hCG as a prognostic marker for colorectal adenocarcinoma in women of reproductive age: A case report and literature review". Medicine International 5.1 (2025): 8.
Chicago
Gong, C., Vikash, F., Silberstein, J., White, S., Kotler, D."Serum β‑hCG as a prognostic marker for colorectal adenocarcinoma in women of reproductive age: A case report and literature review". Medicine International 5, no. 1 (2025): 8. https://doi.org/10.3892/mi.2024.207
Copy and paste a formatted citation
x
Spandidos Publications style
Gong C, Vikash F, Silberstein J, White S and Kotler D: Serum β‑hCG as a prognostic marker for colorectal adenocarcinoma in women of reproductive age: A case report and literature review. Med Int 5: 8, 2025.
APA
Gong, C., Vikash, F., Silberstein, J., White, S., & Kotler, D. (2025). Serum β‑hCG as a prognostic marker for colorectal adenocarcinoma in women of reproductive age: A case report and literature review. Medicine International, 5, 8. https://doi.org/10.3892/mi.2024.207
MLA
Gong, C., Vikash, F., Silberstein, J., White, S., Kotler, D."Serum β‑hCG as a prognostic marker for colorectal adenocarcinoma in women of reproductive age: A case report and literature review". Medicine International 5.1 (2025): 8.
Chicago
Gong, C., Vikash, F., Silberstein, J., White, S., Kotler, D."Serum β‑hCG as a prognostic marker for colorectal adenocarcinoma in women of reproductive age: A case report and literature review". Medicine International 5, no. 1 (2025): 8. https://doi.org/10.3892/mi.2024.207
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