Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Medicine International
Join Editorial Board Propose a Special Issue
Print ISSN: 2754-3242 Online ISSN: 2754-1304
Journal Cover
March-April 2025 Volume 5 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-April 2025 Volume 5 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Prognostic factors for first recurrence following meningioma surgery

  • Authors:
    • George Fotakopoulos
    • Vasiliki Epameinondas Georgakopoulou
    • Demetrios A. Spandidos
    • Efthalia Angelopoulou
    • Apostolos-Alkiviadis Menis
    • Nikolaos Trakas
    • George Alexiou
    • Spyridon Voulgaris
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, General University Hospital of Larissa, 41221 Larissa, Greece, Department of Pathophysiology, Laiko General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece, 1st Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece, Intensive Care Unit, General University Hospital of Larissa, 41221 Larissa, Greece, Department of Biochemistry, Sismanogleio Hospital, 15126 Athens, Greece, Department of Neurosurgery, School of Medicine, University of Ioannina, 45500 Ioannina, Greece
    Copyright: © Fotakopoulos et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 14
    |
    Published online on: December 31, 2024
       https://doi.org/10.3892/mi.2024.213
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study investigated the role of the Simpson grade system, MIB‑1 immunohistochemical marker, meningioma location and grade in the risk of recurrence. Between January, 2008 and January, 2018, the present study retrospectively evaluated all patients undergoing craniotomy for the resection of a histopathologically confirmed meningioma. Patients with neurofibromatosis, acoustic neurinomas and radiation treatment prior to surgery were excluded. After applying the exclusion criteria, 103 patients were included in the study. Following a mean follow‑up period of 67.3±33 months, there were 12 cases (11.6%) of tumor recurrence. No significant association between meningioma recurrence and age, sex, or tumor location was found. When comparing the risk of recurrence between Simpson grades I, II, III and IV excisions, and between Simpson grade V, the difference was statistically significant. When comparing WHO grade I and II meningioma vs. grade III, the difference was significant. MIB‑1 LI >3% exhibited a trend towards a significant association with the risk of recurrence. On the whole, the present study demonstrates that the Simpson grade is associated with the risk of recurrence. Patients with tumors with an MIB‑1 index >3% may also be at a risk of recurrence. Notably, the present study proposed that in the case of recurrence, this is more likely to occur in an interval of 5.5 years following surgical intervention.
View Figures

Figure 1

Figure 2

View References

1 

Oya S, Kawai K, Nakatomi H and Saito N: Significance of Simpson grading system in modern meningioma surgery: Integration of the grade with MIB-1 labeling index as a key to predict the recurrence of WHO grade I meningiomas. J Neurosurg. 117:121–128. 2012.PubMed/NCBI View Article : Google Scholar

2 

Sughrue ME, Kane AJ, Shangari G, Rutkowski MJ, McDermott MW, Berger MS and Parsa AT: The relevance of Simpson Grade I and II resection in modern neurosurgical treatment of World Health Organization Grade I meningiomas. J Neurosurg. 113:1029–1035. 2010.PubMed/NCBI View Article : Google Scholar

3 

Hasseleid BF, Meling TR, Rønning P, Scheie D and Helseth E: Surgery for convexity meningioma: Simpson grade I resection as the goal: Clinical article. J Neurosurg. 117:999–1006. 2012.PubMed/NCBI View Article : Google Scholar

4 

Alvernia JE, Dang ND and Sindou MP: Convexity meningiomas: Study of recurrence factors with special emphasis on the cleavage plane in a series of 100 consecutive patients. J Neurosurg. 115:491–498. 2011.PubMed/NCBI View Article : Google Scholar

5 

Aguiar PH, Tsanaclis AM, Tella OI Jr and Plese JP: Proliferation rate of intracranial meningiomas as defined by the monoclonal antibody MIB-1: Correlation with peritumoural oedema and other clinicoradiological and histological characteristics. Neurosurg Rev. 26:221–228. 2003.PubMed/NCBI View Article : Google Scholar

6 

Amatya VJ, Takeshima Y, Sugiyama K, Kurisu K, Nishisaka T, Fukuhara T and Inai K: Immunohistochemical study of Ki-67 (MIB-1), p53 protein, p21WAF1, and p27KIP1 expression in benign, atypical, and anaplastic meningiomas. Hum Pathol. 32:970–975. 2001.PubMed/NCBI View Article : Google Scholar

7 

Kasuya H, Kubo O, Tanaka M, Amano K, Kato K and Hori T: Clinical and radiological features related to the growth potential of meningioma. Neurosurg Rev. 29:293–296. 2006.PubMed/NCBI View Article : Google Scholar

8 

Kim YJ, Ketter R, Steudel WI and Feiden W: Prognostic significance of the mitotic index using the mitosis marker anti-phosphohistone H3 in meningiomas. Am J Clin Pathol. 128:118–125. 2007.PubMed/NCBI View Article : Google Scholar

9 

Colli BO, Carlotti CG Jr, Assirati JA Jr, Dos Santos MB, Neder L and Dos Santos AC: Parasagittal meningiomas: Follow-up review. Surg Neurol. 66 (Suppl 3):S20–S27. 2006.PubMed/NCBI View Article : Google Scholar

10 

Durand A, Labrousse F, Jouvet A, Bauchet L, Kalamaridès M, Menei P, Deruty R, Moreau JJ, Fèvre-Montange M and Guyotat J: WHO grade II and III meningiomas: A study of prognostic factors. J Neurooncol. 95:367–375. 2009.PubMed/NCBI View Article : Google Scholar

11 

Black PM, Morokoff AP and Zauberman J: Surgery for extra-axial tumors of the cerebral convexity and midline. Neurosurgery. 62 (Suppl 3):S1115–S1121. 2008.PubMed/NCBI View Article : Google Scholar

12 

Celenk F, Erkilic S, Durucu C, Baysal E and Kanlikama M: Late metastasis of an intracranial meningioma to the hard palate. J Craniofac Surg. 23:1912–1914. 2012.PubMed/NCBI View Article : Google Scholar

13 

Wang YC, Chuang CC, Wei KC, Hsu YH, Hsu PW, Lee ST, Wu CT, Tseng CK, Wang CC, Chen YL, et al: Skull base atypical meningioma: Long term surgical outcome and prognostic factors. Clin Neurol Neurosurg. 128:112–116. 2015.PubMed/NCBI View Article : Google Scholar

14 

Ivan ME, Cheng JS, Kaur G, Sughrue ME, Clark A, Kane AJ, Aranda D, McDermott M, Barani IJ and Parsa AT: Association of morbidity with extent of resection and cavernous sinus invasion in sphenoid wing meningiomas. J Neurol Surg B Skull Base. 73:76–83. 2012.PubMed/NCBI View Article : Google Scholar

15 

Bloch O, Sun M, Kaur G, Barani IJ and Parsa AT: Fractionated radiotherapy for optic nerve sheath meningiomas. J Clin Neurosci. 19:1210–1215. 2012.PubMed/NCBI View Article : Google Scholar

16 

Zhang L, Wang Q, Zhu J and Luo C: A modified anterior petrosectomy approach for resection of petroclival meningioma; with management of complications. World Neurosurg. 187(101)2024.PubMed/NCBI View Article : Google Scholar

17 

Bozkurt SU, Ayan E, Bolukbasi F, Elmaci I, Pamir N and Sav A: Immunohistochemical expression of SPARC is correlated with recurrence, survival and malignant potential in meningiomas. APMIS. 117:651–659. 2009.PubMed/NCBI View Article : Google Scholar

18 

Krejchi D, Caldemeyer KS, Vakili ST and Pritz MB: Neurosarcoidosis resembling meningioma: MRI characteristics and pathologic correlation. J Neuroimaging. 8:177–179. 1998.PubMed/NCBI View Article : Google Scholar

19 

Liu Y, Liu M, Li F, Wu C and Zhu S: Malignant meningiomas: A retrospective study of 22 cases. Bull Cancer. 94:E27–E31. 2007.PubMed/NCBI

20 

Nakane Y, Natsume A, Wakabayashi T, Oi S, Ito M, Inao S, Saito K and Yoshida J: Malignant transformation-related genes in meningiomas: Allelic loss on 1p36 and methylation status of p73 and RASSF1A. J Neurosurg. 107:398–404. 2007.PubMed/NCBI View Article : Google Scholar

21 

Rosenberg LA, Prayson RA, Lee J, Reddy C, Chao ST, Barnett GH, Vogelbaum MA and Suh JH: Long-term experience with World Health Organization grade III (malignant) meningiomas at a single institution. Int J Radiat Oncol Biol Phys. 74:427–432. 2009.PubMed/NCBI View Article : Google Scholar

22 

Tao Y, Liang G, Li Z, Wang Y, Wu A, Wang H, Lu Y, Liu Z and Hu G: Clinical features and immunohistochemical expression levels of androgen, estrogen, progesterone and Ki-67 receptors in relationship with gross-total resected meningiomas relapse. Br J Neurosurg. 26:700–704. 2012.PubMed/NCBI View Article : Google Scholar

23 

Jensen R and Lee J: Predicting outcomes of patients with intracranial meningiomas using molecular markers of hypoxia, vascularity, and proliferation. Neurosurgery. 71:146–156. 2012.PubMed/NCBI View Article : Google Scholar

24 

Mukherjee S, Ghosh SN, Chatterjee U and Chatterjee S: Detection of progesterone receptor and the correlation with Ki-67 labeling index in meningiomas. Neurol India. 59:817–822. 2011.PubMed/NCBI View Article : Google Scholar

25 

Jiang L, Wang T, Bao Y, Qian J, Wu XJ, Hu GH and Lu YC: A study of UbcH10 expression and its association with recurrence of meningiomas. J Surg Oncol. 106:327–331. 2012.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Fotakopoulos G, Georgakopoulou VE, Spandidos DA, Angelopoulou E, Menis A, Trakas N, Alexiou G and Voulgaris S: Prognostic factors for first recurrence following meningioma surgery. Med Int 5: 14, 2025.
APA
Fotakopoulos, G., Georgakopoulou, V.E., Spandidos, D.A., Angelopoulou, E., Menis, A., Trakas, N. ... Voulgaris, S. (2025). Prognostic factors for first recurrence following meningioma surgery. Medicine International, 5, 14. https://doi.org/10.3892/mi.2024.213
MLA
Fotakopoulos, G., Georgakopoulou, V. E., Spandidos, D. A., Angelopoulou, E., Menis, A., Trakas, N., Alexiou, G., Voulgaris, S."Prognostic factors for first recurrence following meningioma surgery". Medicine International 5.2 (2025): 14.
Chicago
Fotakopoulos, G., Georgakopoulou, V. E., Spandidos, D. A., Angelopoulou, E., Menis, A., Trakas, N., Alexiou, G., Voulgaris, S."Prognostic factors for first recurrence following meningioma surgery". Medicine International 5, no. 2 (2025): 14. https://doi.org/10.3892/mi.2024.213
Copy and paste a formatted citation
x
Spandidos Publications style
Fotakopoulos G, Georgakopoulou VE, Spandidos DA, Angelopoulou E, Menis A, Trakas N, Alexiou G and Voulgaris S: Prognostic factors for first recurrence following meningioma surgery. Med Int 5: 14, 2025.
APA
Fotakopoulos, G., Georgakopoulou, V.E., Spandidos, D.A., Angelopoulou, E., Menis, A., Trakas, N. ... Voulgaris, S. (2025). Prognostic factors for first recurrence following meningioma surgery. Medicine International, 5, 14. https://doi.org/10.3892/mi.2024.213
MLA
Fotakopoulos, G., Georgakopoulou, V. E., Spandidos, D. A., Angelopoulou, E., Menis, A., Trakas, N., Alexiou, G., Voulgaris, S."Prognostic factors for first recurrence following meningioma surgery". Medicine International 5.2 (2025): 14.
Chicago
Fotakopoulos, G., Georgakopoulou, V. E., Spandidos, D. A., Angelopoulou, E., Menis, A., Trakas, N., Alexiou, G., Voulgaris, S."Prognostic factors for first recurrence following meningioma surgery". Medicine International 5, no. 2 (2025): 14. https://doi.org/10.3892/mi.2024.213
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team