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Evaluation of the association between serum danger molecules at diagnosis and survival outcomes in patients with diffuse large B cell lymphoma

  • Authors:
    • Rafiye Çiftçiler
    • Ali Erdinc Ciftciler
    • Cem Selim
  • View Affiliations

    Affiliations: Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Selçuk University, 42131 Konya, Turkey, Department of General Surgery, Konya Numune Hospital, 42060 Konya, Turkey
  • Published online on: March 5, 2025     https://doi.org/10.3892/mi.2025.224
  • Article Number: 25
  • Copyright : © Çiftçiler et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

When cellular stress or tissue injury occurs, molecules known as damage‑associated molecular patterns are generated. The aim of the present was to examine the association between serum danger molecules and survival outcomes in patients with diffuse large B cell lymphoma (DLBCL) at the time of diagnosis. The present study was carried out retrospectively. An evaluation was conducted on 122 patients with DLBCL who were diagnosed at a tertiary care center between 2011 and 2024. The laboratory results of the patients diagnosed with DLBCL, which were examined in detail at diagnosis, were examined retrospectively. The median age of the patients was 59 years (range, 22‑87 years) and 56.6% (n=69) of the patients were female. The 5‑year overall survival (OS) rates of the patients who had a fibrinogen level ≤424 mg/dl and of those who had a fibrinogen level >424 mg/dl at the time of diagnosis were 82 and 41%, respectively (P<0.001). The 5‑year progression‑free survival (PFS) rates of the patients with a fibrinogen level ≤424 mg/dl and of those with a fibrinogen level >424 mg/dl at the time of diagnosis were 91 and 63%, respectively (P=0.002). The 5‑year OS rates of patients with a uric acid level ≤5 mg/dl and those with a uric acid level >5 mg/dl at the time of diagnosis were 74 and 44%, respectively (P=0.008). The 5‑year PFS rates of patients with a uric acid level ≤5 mg/dl and those with a uric acid level >5 mg/dl at the time of diagnosis were 83 and 71%, respectively (P=0.95). On the whole, the present study demonstrates that high uric acid and fibrinogen levels are negative prognostic factors for the OS and PFS of patients with DLBCL. These data may indicate that uric acid and fibrinogen levels at the time of diagnosis may provide predictive information to the existing library of clinical risk prediction tools in DLBCL.
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1 

Pizzi M, Boi M, Bertoni F and Inghirami G: Emerging therapies provide new opportunities to reshape the multifaceted interactions between the immune system and lymphoma cells. Leukemia. 30:1805–1815. 2016.PubMed/NCBI View Article : Google Scholar

2 

Roh JS and Sohn DH: Damage-associated molecular patterns in inflammatory diseases. Immune Netw. 18(e27)2018.PubMed/NCBI View Article : Google Scholar

3 

Chen GY and Nuñez G: Sterile inflammation: Sensing and reacting to damage. Nat Rev Immunol. 10:826–837. 2010.PubMed/NCBI View Article : Google Scholar

4 

Vénéreau E, Ceriotti C and Bianchi ME: DAMPs from cell death to new life. Front Immunol. 6(422)2015.PubMed/NCBI View Article : Google Scholar

5 

Land WG: The role of damage-associated molecular patterns (DAMPs) in human diseases: Part II: DAMPs as diagnostics, prognostics and therapeutics in clinical medicine. Sultan Qaboos Univ Med J. 15:e157–e170. 2015.PubMed/NCBI

6 

Braga TT, Forni MF, Correa-Costa M, Ramos RN, Barbuto JA, Branco P, Castoldi A, Hiyane MI, Davanso MR, Latz E, et al: Soluble uric acid activates the NLRP3 inflammasome. Sci Rep. 7(39884)2017.PubMed/NCBI View Article : Google Scholar

7 

Grivennikov SI, Greten FR and Karin M: Immunity, inflammation, and cancer. Cell. 140:883–899. 2010.PubMed/NCBI View Article : Google Scholar

8 

Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, et al: A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell. 16:295–308. 2009.PubMed/NCBI View Article : Google Scholar

9 

Hernandez C, Huebener P and Schwabe RF: Damage-associated molecular patterns in cancer: A double-edged sword. Oncogene. 35:5931–5941. 2016.PubMed/NCBI View Article : Google Scholar

10 

Matzinger P: Tolerance, danger, and the extended family. Annu Rev Immunol. 12:991–1045. 1994.PubMed/NCBI View Article : Google Scholar

11 

Schaefer L: Complexity of danger: The diverse nature of damage-associated molecular patterns. J Biol Chem. 289:35237–35245. 2014.PubMed/NCBI View Article : Google Scholar

12 

Zhang X and Mosser DM: Macrophage activation by endogenous danger signals. J Pathol. 214:161–178. 2008.PubMed/NCBI View Article : Google Scholar

13 

Smiley ST, King JA and Hancock WW: Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol. 167:2887–2894. 2001.PubMed/NCBI View Article : Google Scholar

14 

Ye RD and Sun L: Emerging functions of serum amyloid A in inflammation. J Leukoc Biol. 98:923–929. 2015.PubMed/NCBI View Article : Google Scholar

15 

Lawrence SO and Simpson-Haidaris PJ: Regulated de novo biosynthesis of fibrinogen in extrahepatic epithelial cells in response to inflammation. Thromb Haemost. 92:234–243. 2004.PubMed/NCBI View Article : Google Scholar

16 

Polterauer S, Grimm C, Seebacher V, Concin N, Marth C, Tomovski C, Husslein H, Leipold H, Hefler-Frischmuth K, Tempfer C, et al: Plasma fibrinogen levels and prognosis in patients with ovarian cancer: A multicenter study. Oncologist. 14:979–985. 2009.PubMed/NCBI View Article : Google Scholar

17 

Xu Q, Yan Y, Gu S, Mao K, Zhang J, Huang P, Zhou Z, Chen Z, Zheng S, Liang J, et al: A novel inflammation-based prognostic score: The fibrinogen/albumin ratio predicts prognoses of patients after curative resection for hepatocellular carcinoma. J Immunol Res. 2018(4925498)2018.PubMed/NCBI View Article : Google Scholar

18 

Shehata AMF, Aldesoky AI and Gohar SF: Plasma fibrinogen level as possible prognostic biomarker in diffuse large B-cell lymphoma. Hematology. 24:103–107. 2019.PubMed/NCBI View Article : Google Scholar

19 

Wang JW, Li KC, Shi Z and Tang X: Clinical significance of plasma fibrinogen level in patients with non-Hodgkin's lymphoma. Tumor. 34:370–373. 2014.

20 

Troppan KT, Melchardt T, Wenzl K, Schlick K, Deutsch A, Bullock MD, Reitz D, Beham-Schmid C, Weiss L, Neureiter D, et al: The clinical significance of fibrinogen plasma levels in patients with diffuse large B cell lymphoma. J Clin Pathol. 69:326–330. 2016.PubMed/NCBI View Article : Google Scholar

21 

Stotz M, Szkandera J, Seidel J, Stojakovic T, Samonigg H, Reitz D, Gary T, Kornprat P, Schaberl-Moser R, Hoefler G, et al: Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients. PLoS One. 9(e104730)2014.PubMed/NCBI View Article : Google Scholar

22 

Yan S, Zhang P, Xu W, Liu Y, Wang B, Jiang T, Hua C, Wang X, Xu D and Sun B: Serum uric acid increases risk of cancer incidence and mortality: A systematic review and meta-analysis. Mediators Inflamm. 2015(764250)2015.PubMed/NCBI View Article : Google Scholar

23 

Chen YF, Li Q, Chen DT, Pan JH, Chen YH, Wen ZS and Zeng WA: Prognostic value of pre-operative serum uric acid levels in esophageal squamous cell carcinoma patients who undergo R0 esophagectomy. Cancer Biomark. 17:89–96. 2016.PubMed/NCBI View Article : Google Scholar

24 

Prochazka KT, Melchardt T, Posch F, Schlick K, Deutsch A, Beham-Schmid C, Weiss L, Gary T, Neureiter D, Klieser E, et al: NCCN-IPI score-independent prognostic potential of pretreatment uric acid levels for clinical outcome of diffuse large B-cell lymphoma patients. Br J Cancer. 115:1264–1272. 2016.PubMed/NCBI View Article : Google Scholar

25 

Çelik S, Kaynar L, Güven ZT, Atasever Duran K, Kontaş O, Keklik M and Ünal A: The effect of danger-associated molecular patterns on survival in acute graft versus host disease. Bone Marrow Transplant. 59:189–195. 2024.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Çiftçiler R, Ciftciler AE and Selim C: Evaluation of the association between serum danger molecules at diagnosis and survival outcomes in patients with diffuse large B cell lymphoma. Med Int 5: 25, 2025.
APA
Çiftçiler, R., Ciftciler, A.E., & Selim, C. (2025). Evaluation of the association between serum danger molecules at diagnosis and survival outcomes in patients with diffuse large B cell lymphoma. Medicine International, 5, 25. https://doi.org/10.3892/mi.2025.224
MLA
Çiftçiler, R., Ciftciler, A. E., Selim, C."Evaluation of the association between serum danger molecules at diagnosis and survival outcomes in patients with diffuse large B cell lymphoma". Medicine International 5.3 (2025): 25.
Chicago
Çiftçiler, R., Ciftciler, A. E., Selim, C."Evaluation of the association between serum danger molecules at diagnosis and survival outcomes in patients with diffuse large B cell lymphoma". Medicine International 5, no. 3 (2025): 25. https://doi.org/10.3892/mi.2025.224
Copy and paste a formatted citation
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Spandidos Publications style
Çiftçiler R, Ciftciler AE and Selim C: Evaluation of the association between serum danger molecules at diagnosis and survival outcomes in patients with diffuse large B cell lymphoma. Med Int 5: 25, 2025.
APA
Çiftçiler, R., Ciftciler, A.E., & Selim, C. (2025). Evaluation of the association between serum danger molecules at diagnosis and survival outcomes in patients with diffuse large B cell lymphoma. Medicine International, 5, 25. https://doi.org/10.3892/mi.2025.224
MLA
Çiftçiler, R., Ciftciler, A. E., Selim, C."Evaluation of the association between serum danger molecules at diagnosis and survival outcomes in patients with diffuse large B cell lymphoma". Medicine International 5.3 (2025): 25.
Chicago
Çiftçiler, R., Ciftciler, A. E., Selim, C."Evaluation of the association between serum danger molecules at diagnosis and survival outcomes in patients with diffuse large B cell lymphoma". Medicine International 5, no. 3 (2025): 25. https://doi.org/10.3892/mi.2025.224
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