Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Medicine International
Join Editorial Board Propose a Special Issue
Print ISSN: 2754-3242 Online ISSN: 2754-1304
Journal Cover
May-June 2025 Volume 5 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-June 2025 Volume 5 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

IgG4‑related disease with endobronchial nodules: A case report and literature review

  • Authors:
    • Cheuk Cheung Derek Leung
    • Yu Hong Chan
    • Man Ying Ho
    • Yiu Cheong Yeung
  • View Affiliations / Copyright

    Affiliations: Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, SAR, P.R. China, Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, SAR, P.R. China
    Copyright: © Leung et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 28
    |
    Published online on: March 18, 2025
       https://doi.org/10.3892/mi.2025.227
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present case report describes the case of a rare presentation of IgG4‑related lung disease (IgG4‑RLD) with endobronchial nodules and systemic involvement. An 84‑year‑old male presented with unexplained weight loss and enlarged submandibular lymph nodes. Diagnostic examinations revealed elevated serum IgG4 levels, along with findings of endobronchial nodules during bronchoscopy. Biopsies of endobronchial nodules revealed benign bronchial mucosa with fibrosis and inflammatory infiltration; however, he was not diagnosed with IgG4‑RLD. A histological examination of the left salivary gland and submandibular lymph nodes confirmed the diagnosis of IgG4‑related disease, revealing storiform fibrosis and abundant IgG4‑positive plasma cells. The patient was treated with prednisolone, resulting in a reduction in submandibular swelling and decreased serum IgG4 levels. This case emphasizes the importance of considering IgG4‑RLD as a potential diagnosis in patients presenting with endobronchial nodules and systemic disease. Accurate sampling methods, such as surgical lung biopsy or transbronchial cryobiopsies, are crucial for definitive diagnosis. Increased awareness among physicians can lead to timely recognition and appropriate management of this rare condition.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Uchida K, Masamune A, Shimosegawa T and Okazaki K: Prevalence of IgG4-related disease in Japan based on nationwide survey in 2009. Int J Rheumatol. 2012(358371)2012.PubMed/NCBI View Article : Google Scholar

2 

Sato T, Minegishi K, Okabe N, Osuga F, Sudo K, Sogabe M, Endo S and Tsubochi H: Bronchial obstruction in immunoglobulin G4-related disease. Ann Thorac Surg Short Rep, 2024.

3 

Sarles H, Sarles JC, Muratore R and Guien C: Chronic inflammatory sclerosis of the pancreas-an autonomous pancreatic disease? Am J Dig Dis. 6:688–698. 1961.PubMed/NCBI View Article : Google Scholar

4 

Kamisawa T, Funata N, Hayashi Y, Eishi Y, Koike M, Tsuruta K, Okamoto A, Egawa N and Nakajima H: A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 38:982–984. 2003.PubMed/NCBI View Article : Google Scholar

5 

Wallace ZS, Naden RP, Chari S, Choi H, Della-Torre E, Dicaire JF, Hart PA, Inoue D, Kawano M, Khosroshahi A, et al: The 2019 American college of rheumatology/European league against rheumatism classification criteria for IgG4-related disease. Arthritis Rheumatol. 72:7–19. 2020.PubMed/NCBI View Article : Google Scholar

6 

Stone JH, Khosroshahi A, Deshpande V, Chan JKC, Heathcote JG, Aalberse R, Azumi A, Bloch DB, Brugge WR, Carruthers MN, et al: Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations. Arthritis Rheum. 64:3061–3067. 2012.PubMed/NCBI View Article : Google Scholar

7 

Wang X, Wan J, Zhao L, Da J, Cao B and Zhai Z: IgG4-related disease with tracheobronchial miliary nodules and asthma: A case report and review of the literature. BMC Pulm Med. 19(191)2019.PubMed/NCBI View Article : Google Scholar

8 

Umehara H, Okazaki K, Kawa S, Takahashi H, Goto H, Matsui S, Ishizaka N, Akamizu T, Sato Y, Kawano M, et al: The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD. Mod Rheumatol. 31:529–533. 2021.PubMed/NCBI View Article : Google Scholar

9 

Li PH, Ko K, Ho CT, Lau LL, Tsang RK, Cheung T, Leung WK and Lau CS: Immunoglobulin G4-related disease in Hong Kong: Clinical features, treatment practices, and its association with multisystem disease. Hong Kong Med J. 23:446–453. 2017.PubMed/NCBI View Article : Google Scholar

10 

Matsui S: IgG4-related respiratory disease. Mod Rheumatol. 29:251–256. 2019.PubMed/NCBI View Article : Google Scholar

11 

Matsui S, Hebisawa A, Sakai F, Yamamoto H, Terasaki Y, Kurihara Y, Waseda Y, Kawamura T, Miyashita T, Inoue H, et al: Immunoglobulin G4-related lung disease: Clinicoradiological and pathological features. Respirology. 18:480–487. 2013.PubMed/NCBI View Article : Google Scholar

12 

Yamakawa H, Takemura T, Tsumiyama E, Sato S, Akasaka K, Amano M and Matsushima H: IgG4-related bronchial gland inflammation proved by transbronchial cryobiopsy. Am J Respir Crit Care Med. 201:1554–1556. 2020.PubMed/NCBI View Article : Google Scholar

13 

Shrestha B, Sekiguchi H, Colby TV, Graziano P, Aubry MC, Smyrk TC, Feldman AL, Cornell LD, Ryu JH, Chari ST, et al: Distinctive pulmonary histopathology with increased IgG4-positive plasma cells in patients with autoimmune pancreatitis: report of 6 and 12 cases with similar histopathology. Am J Surg Pathol. 33:1450–1462. 2009.PubMed/NCBI View Article : Google Scholar

14 

Torii A, Oshima K, Iwakoshi A and Oki M: A case with multiple nodules and mucosal oedema of the trachea and both bronchi induced by IgG4-related disease. BMC Pulm Med. 24(115)2024.PubMed/NCBI View Article : Google Scholar

15 

Otani K, Inoue D, Fujikura K, Komori T, Abe-Suzuki S, Tajiri T, Itoh T and Zen Y: Idiopathic multicentric Castleman's disease: A clinicopathologic study in comparison with IgG4-related disease. Oncotarget. 9:6691–6706. 2018.PubMed/NCBI View Article : Google Scholar

16 

Ebbo M, Grados A, Bernit E, Vély F, Boucraut J, Harlé JR, Daniel L and Schleinitz N: Pathologies associated with serum IgG4 elevation. Int J Rheumatol. 2012:1–6. 2012.PubMed/NCBI View Article : Google Scholar

17 

Otani K, Inoue D, Itoh T and Zen Y: Transbronchial lung biopsy for the diagnosis of IgG4-related lung disease. Histopathology. 73:49–58. 2018.PubMed/NCBI View Article : Google Scholar

18 

Tanaka Y and Stone JH: Perspectives on current and emerging therapies for immunoglobulin G4-related disease. Mod Rheumatol. 33:229–236. 2023.PubMed/NCBI View Article : Google Scholar

19 

Ebbo M, Grados A, Samson M, Groh M, Loundou A, Rigolet A, Terrier B, Guillaud C, Carra-Dallière C, Renou F, et al: Long-term efficacy and safety of rituximab in IgG4-related disease: Data from a French nationwide study of thirty-three patients. PLoS One. 12(e0183844)2017.PubMed/NCBI View Article : Google Scholar

20 

Stone JH, Khosroshahi A, Zhang W, Della Torre E, Okazaki K, Tanaka Y, Löhr JM, Schleinitz N, Dong L, Umehara H, et al: Inebilizumab for treatment of IgG4-related disease. N Engl J Med: Nov 14, 2024 (Epub ahead of print).

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Leung C, Chan Y, Ho M and Yeung Y: IgG4‑related disease with endobronchial nodules: A case report and literature review. Med Int 5: 28, 2025.
APA
Leung, C., Chan, Y., Ho, M., & Yeung, Y. (2025). IgG4‑related disease with endobronchial nodules: A case report and literature review. Medicine International, 5, 28. https://doi.org/10.3892/mi.2025.227
MLA
Leung, C., Chan, Y., Ho, M., Yeung, Y."IgG4‑related disease with endobronchial nodules: A case report and literature review". Medicine International 5.3 (2025): 28.
Chicago
Leung, C., Chan, Y., Ho, M., Yeung, Y."IgG4‑related disease with endobronchial nodules: A case report and literature review". Medicine International 5, no. 3 (2025): 28. https://doi.org/10.3892/mi.2025.227
Copy and paste a formatted citation
x
Spandidos Publications style
Leung C, Chan Y, Ho M and Yeung Y: IgG4‑related disease with endobronchial nodules: A case report and literature review. Med Int 5: 28, 2025.
APA
Leung, C., Chan, Y., Ho, M., & Yeung, Y. (2025). IgG4‑related disease with endobronchial nodules: A case report and literature review. Medicine International, 5, 28. https://doi.org/10.3892/mi.2025.227
MLA
Leung, C., Chan, Y., Ho, M., Yeung, Y."IgG4‑related disease with endobronchial nodules: A case report and literature review". Medicine International 5.3 (2025): 28.
Chicago
Leung, C., Chan, Y., Ho, M., Yeung, Y."IgG4‑related disease with endobronchial nodules: A case report and literature review". Medicine International 5, no. 3 (2025): 28. https://doi.org/10.3892/mi.2025.227
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team