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Transient myoclonic state or transient myoclonic state with asterixis: A systematic review

  • Authors:
    • Jamir Pitton Rissardo
    • Nilofar Murtaza Vora
    • Nirali Seth
    • Sanobar Shariff
    • Ana Letícia Fornari Caprara
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Cooper University Hospital, Camden, NJ 08103, USA, Department of Medicine, Terna Speciality Hospital, Navi Mumbai 400706, India, Department of Medicine, Lady Hardinge Medical College, Delhi 110001, India, Department of Medicine, Yerevan State Medical University, Yerevan 0025, Armenia
    Copyright: © Rissardo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 29
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    Published online on: March 19, 2025
       https://doi.org/10.3892/mi.2025.228
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Abstract

Transient myoclonic state (TMS) is a rare type of myoclonic jerks occurring predominantly in the upper extremities involving the head and commonly associated with asterixis. The present study performed a systematic review of published articles on this condition. For this purpose, six databases were searched by two reviewers to identify reports on TMS published online until November, 2024. A total of 17 reports containing 78 cases were found. Almost all the reports were from Japan, apart from one case reported in the USA. The mean age of the patients was 75.67 years (standard deviation, 5.8 years) and the median age was 75 years (range, 54 to 84 years). Sex was reported in 74 reports, and 60.8% of the patients were males. A precipitating factor, such as an infectious disease or the introduction of a new medication was observed in 24 cases (30.7%). All individuals achieved full recovery; however, 53 patients (67.9%) required benzodiazepine therapy, while the remaining individuals improved spontaneously. In summary, the present systematic review demonstrates that TMS is a rare condition, and is mainly encountered in Japan by unknown factors. There are likely genetic and environmental factors involved in its development; however, no specific geolocation related to the occurrence of TMS in Japan was found. It has a benign course and usually improves with the prescription of benzodiazepines. Management strategies include ensuring adequate multidisciplinary care coordination, as well as educating patients and their families about TMS. Future studies are required to describe the cases of TMS, including videos of the phenomenology. It is also recommended to perform whole genome sequencing analysis in patients with TMS.
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Spandidos Publications style
Rissardo J, Vora NM, Seth N, Shariff S and Fornari Caprara AL: Transient myoclonic state or transient myoclonic state with asterixis: A systematic review. Med Int 5: 29, 2025.
APA
Rissardo, J., Vora, N.M., Seth, N., Shariff, S., & Fornari Caprara, A.L. (2025). Transient myoclonic state or transient myoclonic state with asterixis: A systematic review. Medicine International, 5, 29. https://doi.org/10.3892/mi.2025.228
MLA
Rissardo, J., Vora, N. M., Seth, N., Shariff, S., Fornari Caprara, A. L."Transient myoclonic state or transient myoclonic state with asterixis: A systematic review". Medicine International 5.3 (2025): 29.
Chicago
Rissardo, J., Vora, N. M., Seth, N., Shariff, S., Fornari Caprara, A. L."Transient myoclonic state or transient myoclonic state with asterixis: A systematic review". Medicine International 5, no. 3 (2025): 29. https://doi.org/10.3892/mi.2025.228
Copy and paste a formatted citation
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Spandidos Publications style
Rissardo J, Vora NM, Seth N, Shariff S and Fornari Caprara AL: Transient myoclonic state or transient myoclonic state with asterixis: A systematic review. Med Int 5: 29, 2025.
APA
Rissardo, J., Vora, N.M., Seth, N., Shariff, S., & Fornari Caprara, A.L. (2025). Transient myoclonic state or transient myoclonic state with asterixis: A systematic review. Medicine International, 5, 29. https://doi.org/10.3892/mi.2025.228
MLA
Rissardo, J., Vora, N. M., Seth, N., Shariff, S., Fornari Caprara, A. L."Transient myoclonic state or transient myoclonic state with asterixis: A systematic review". Medicine International 5.3 (2025): 29.
Chicago
Rissardo, J., Vora, N. M., Seth, N., Shariff, S., Fornari Caprara, A. L."Transient myoclonic state or transient myoclonic state with asterixis: A systematic review". Medicine International 5, no. 3 (2025): 29. https://doi.org/10.3892/mi.2025.228
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