Ulcerative fibroepithetial stromal polyp of the vulva with strong clinical suspicion for vulvar malignancy: A case report and mini‑review of the literature

Thanasa,Efthymia; Thanasa,Anna; Antoniou,Ioannis-Rafail; Xydias,Emmanouil; Ziogas,Apostolos; Kamaretsos,Evangelos; Chasiotis,Athanasios; Leroutsos,Alexandros; Simopoulou,Evangelia; Mousia,Maria; Thanasas,Ioannis

doi:10.3892/mi.2025.230

Ulcerative fibroepithetial stromal polyp of the vulva with strong clinical suspicion for vulvar malignancy: A case report and mini‑review of the literature

Authors:
- Efthymia Thanasa
- Anna Thanasa
- Ioannis-Rafail Antoniou
- Emmanouil Xydias
- Apostolos Ziogas
- Evangelos Kamaretsos
- Athanasios Chasiotis
- Alexandros Leroutsos
- Evangelia Simopoulou
- Maria Mousia
- Ioannis Thanasas
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Affiliations: Department of Health Sciences, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece, Department of Obstetrics and Gynecology, General Hospital of Trikala, 42100 Trikala, Greece, Department of Obstetrics and Gynaecology, EmbryoClinic IVF, 55133 Thessaloniki, Greece, Department of Medicine, University of Thessaly, School of Health Sciences, 41334 Larissa, Greece, Department of Pathology, General Hospital of Trikala, 42100 Trikala, Greece
Published online on: April 1, 2025 https://doi.org/10.3892/mi.2025.230
Article Number: 31
Copyright : © Thanasa et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Fibroepithelial stromal polyps of the vulva are rare clinical entities, typically appearing as isolated polypoid stromal lesions, covered by squamous epithelium. The presence of non‑traumatic ulcerative lesions on the tumor surface, particularly when the tumor is relatively small, necessitates the differentiation from malignant lesions of the vulva. The present study describes the case of a 44‑year‑old patient who presented to an outpatient gynecological clinic, reporting as her sole symptom the presence of a mass in the vulval region, which had been increasing in size over the past 12 months. Upon examination and palpation of the external genitalia, a painless pedunculated tumor measuring ~5 cm, originating from the upper third of the right labium majus, covered with normal skin, but bearing ulcerative lesions, was found. An ulcerative fibroepithelial polyp of the vulva was suspected, and surgical treatment with wide excision of the lesion was decided upon. A histological examination of the surgical specimen confirmed the diagnosis. The immunohistochemical analysis of the tumor ruled out malignancy. Following an uneventful post‑operative course, the patient was discharged from the clinic the following day. At 6 months post‑operatively, no recurrence of the fibroepithelial polyp was found at the site of pedicle resection. The present study, also provides a brief literature review of this rare disease entity following the case presentation, highlighting the necessity of wide surgical excision of vulvar fibroepithelial polyps and their differentiation from vulvar malignancies.

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