Aggressive intracranial meningioma associated with multiple sclerosis: A case report and literature review

Patel,Tirath; Fatima,Iram; Chandrasekaran,Sai Harini; Rameshkumar,Sai Sakthi; Makky,Hend; Ali,Sofia; Suvra Patra,Soumya; Qamar,Yusra

doi:10.3892/mi.2025.243

Aggressive intracranial meningioma associated with multiple sclerosis: A case report and literature review

Authors:
- Tirath Patel
- Iram Fatima
- Sai Harini Chandrasekaran
- Sai Sakthi Rameshkumar
- Hend Makky
- Sofia Ali
- Soumya Suvra Patra
- Yusra Qamar
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Affiliations: Trinity Medical Sciences University School of Medicine, Kingstown VC0100, Saint Vincent and the Grenadines, Holy Name Medical Center, Teaneck, NJ 07666, USA, Government Medical College Omandurar, Chennai, Tamil Nadu 600002, India, Faculty of Medicine, Assiut University, Assiut 71515, Egypt, Peninsula Medical School, University of Plymouth, Derriford Road, Plymouth PL6 8BT, UK, Calcutta National Medical College, Kolkata, West Bengal 700014, India, Department of Obstetrics and Gynecology, King George's Medical University, Lucknow, Uttar Pradesh 226003, India
Published online on: May 21, 2025 https://doi.org/10.3892/mi.2025.243
Article Number: 44
Copyright : © Patel et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Meningiomas are the most common primary tumors of the central nervous system (CNS) and often require radiation therapy (RT), which can lead to the development of complications, such as radiation‑induced demyelination. The present study describes the case of a 40‑year‑old male patient who developed demyelinating lesions following RT for a WHO grade I meningioma, ultimately diagnosed with MS. This condition shares clinical and radiological features with multiple sclerosis, including damage to oligodendrocytes, which are the cells responsible for myelination in the CNS, cognitive impairment, motor dysfunction, and white matter abnormalities on magnetic resonance imaging (MRI). Distinguishing between radiation‑induced demyelination and multiple sclerosis can be challenging, particularly in patients with a history of radiation therapy, as MRI findings often overlap. Additionally, radiation therapy may trigger or exacerbate multiple sclerosis in individuals with pre‑existing risk factors or undiagnosed multiple sclerosis. A thorough clinical history, advanced neuroimaging, and careful differential diagnosis are essential for accurate management of these conditions.

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