Unilateral breast Darier disease: A case report and literature review
- Authors:
- Lana R.A. Pshtiwan
- Shaban Latif Tofiq
- Dilan S. Hiwa
- Harzal Hiwa Fatih
- Karukh K. Mohammed
- Abdulwahid M. Salih
- Diyar A. Omar
- Kayhan A. Najar
- Fahmi H. Kakamad
-
View Affiliations
Affiliations: Department of Scientific Affairs, Smart Health Tower, Sulaymaniyah 46001, Iraq, Smart Health Tower (Raparin Branch), Ranya, Sulaymaniyah 46001, Iraq, Kscien Organization for Scientific Research (Middle East office), Sulaymaniyah 46001, Iraq
- Published online on: May 26, 2025 https://doi.org/10.3892/mi.2025.244
-
Article Number:
45
-
Copyright : © Pshtiwan
et al. This
is an open access article distributed under the
terms of Creative
Commons Attribution License [CC BY 4.0].
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Abstract
Darier disease is often an underrecognized, disfiguring skin condition. Although the localized form of this condition has been reported in several parts of the body, the present study describes the case of a patient with the unique involvement of one breast, destroying the nipple. A 35‑year‑old female patient complained of having a right nipple lesion for 1 month. There were multiple small brown‑to‑black firm nipple lesions causing nipple destruction, associated with multiple small red, non‑tender skin lesions in the areolar region and lower part of the breast. An incisional biopsy revealed a small number of acantholytic cells and a papillary‑like configuration within the epidermis; no conclusive evidence of malignancy was observed, and a diagnosis of Darier disease was made. Emollient lotion, topical fusidic acid cream 2%, and oral isotretinoin 20 mg once daily were prescribed. The proposed pathogenesis of localized Darier disease is due to genetic mosaicism; these mutations arise during zygotic division. It can present as a rash with either macular or linear patterns confined to a specific body area. In the literature review, localized Darier disease affecting the inframammary region, vulva, axilla, and side of the abdomen have been reported, among others. Paget's disease was hidden in the background of Darier's disease of the breast in one of the cases in the literature. Darier disease may present as a localized unilateral breast lesion, characterized by multiple small, firm brown to black lesions on the nipple, leading to nipple destruction.
View References
|
1
|
Takagi A, Kamijo M and Ikeda S: Darier
disease. J Dermatol. 43:275–279. 2016.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Fitzgerald DA and Lewis-Jones MS: Darier's
disease presenting as isolated hyperkeratosis of the breasts. Br J
Dermatol. 136(290)1997.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Linder D, Marinello E, Donisi PM, Salmaso
R, Zattra E and Zampetti A: Inframammary dermatitis: A case of
localized late-onset Darier's disease. Case Rep Dermatol.
8:189–192. 2016.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Spizuoco A, Jain RD, Stockton T, Kessler
SE and Hamacher KL: Mammary Paget disease in Darier disease: Beware
the wolf in sheep's clothing. Am J Dermatopathol. 34:449–451.
2012.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Abdullah HO, Abdalla B, Kakamad FH, Ahmed
JO, Baba HO, Nasih M, Bapir R, Rahim HM, Omar D, Kakamad SH, et al:
Predatory publishing lists: A review on the ongoing battle against
fraudulent actions. Barw Med J. 2:26–30. 2024.
|
|
6
|
Prasad S, Nassar M, Azzam AY,
García-Muro-San José F, Jamee M, Sliman RK, Evola G, Mustafa A,
Abdullah HQ, Abdalla B, et al: CaReL guidelines: A Consensus-based
guideline on case reports and literature review (CaReL). Barw Med
J. 2:13–19. 2024.
|
|
7
|
Salopek TG, Krol A and Jimbow K: Case
report of Darier disease localized to the vulva in a 5-year-old
girl. Pediatr Dermatol. 10:146–148. 1993.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Barrett JF, Murray LA and MacDonald HN:
Darier's disease localized to the vulva. Case report. Br J Obstet
Gynaecol. 96:997–999. 1989.PubMed/NCBI View Article : Google Scholar
|
|
9
|
O'Malley MP, Haake A, Goldsmith L and Berg
D: Localized Darier disease: Implications for genetic studies. Arch
Dermatol. 133:1134–1138. 1997.PubMed/NCBI
|
|
10
|
Mingomataj E, Krasniqi M, Dedushi K,
Sergeevich KA, Kust D and Qadir AA: Cancer publications in one year
(2023): A Cross-sectional study. Barw Med J. 2:3–11. 2024.
|
|
11
|
Mayuzumi N, Ikeda S, Kawada H and Ogawa H:
Effects of drugs and anticytokine antibodies on expression of
ATP2A2 and ATP2C1 in cultured normal human keratinocytes. Br J
Dermatol. 152:920–924. 2005.PubMed/NCBI View Article : Google Scholar
|
