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Case Report Open Access

Multiple relapses of mantle cell lymphoma as different extranodal lesions: A case report

  • Authors:
    • Masahiro Manabe
    • Daisuke Aohara
    • Daiki Mukai
    • Satoru Nanno
    • Ki-Ryang Koh
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Osaka General Hospital of West Japan Railway Company, Osaka 545‑0053, Japan, Department of Respiratory Medicine, Osaka City General Hospital, Osaka 534‑0021, Japan
    Copyright: © Manabe et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 85
    |
    Published online on: October 31, 2025
       https://doi.org/10.3892/mi.2025.284
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Abstract

Mantle cell lymphoma (MCL) usually affects the lymph nodes; however, extranodal involvement is also common, particularly in Waldeyer's ring and the gastrointestinal tract, spleen and bone marrow. Other organs that may be affected include the skin, endocrine glands, lungs and central nervous system, with these sites most commonly affected by relapsing disease. However, in rare, extranodal MCL has arisen in the ocular adnexa, soft tissue and heart. The present study reports the case of a 75‑year‑old male patient, who experienced repeated relapses of MCL, involving ocular adnexa, soft‑tissue and cardiac lesions, which are rare. The aim of the present case report was to demonstrate that clinicians should be aware of the various extranodal sites at which MCL can arise, and monitor patients carefully during and after treatment.
View Figures

Figure 1

Computed tomography revealed (A) a
swollen right cervical lymph node (arrow) and (B) a supraclavicular
lymph node (arrow).

Figure 2

Pathological examinations of the (A)
lymph node, (B) eyelid, and (C) popliteal mass revealed positivity
for Ki-67 (magnification, x400).

Figure 3

(A) Computed tomography scan
illustrating a mass in the right orbit. (B) Following radiotherapy,
the mass disappeared. (C) The conjunctival mass was composed of
diffuse, dense sheets of atypical cells (hematoxylin and eosin
staining; magnification, x400). The abnormal cells were
immunopositive for (D) Bcl-2 (magnification, x400), (E) cyclin D1
(magnification, x400), and (F) CD5 (magnification, x400), and
negative for (G) CD10 (magnification, x400), and (H) CD23
(magnification, x400).

Figure 4

(A and B) Magnetic resonance images
(T2-weighted images) of the left popliteal fossa are shown; (A)
sagittal view and (B) axial view. (B) The mass exhibited homogenous
signal intensity and encased the popliteal artery (arrowhead). A
computed tomography scan revealed (C) a left popliteal mass, and
(D) the mass regressed following external-beam radiotherapy.

Figure 5

FISH analyses of (A) the popliteal
mass and (B) bone marrow cells using CCND1/IGH fusion probe. (A) In
949 interphase nuclei out of 1,000 analyzed cells, 1 CCND1/IGH
fusion signal (arrowhead), 1 CCND1 red signal (thick arrow) and 1
IGH green signal (thin arrow) were detected. (B) In 12 interphase
nuclei out of 1,000 analyzed cells, two CCND1/IGH fusion signals
(arrowheads), one CCND1 red signal (thick arrow), and one IGH green
signal (thin arrow) were detected. FISH, fluorescent in situ
hybridization.

Figure 6

A computed tomography scan revealed
(A) mass lesions in the right atrium (asterisks); (B) the disease
improved within 4 months with ibrutinib monotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Manabe M, Aohara D, Mukai D, Nanno S and Koh K: Multiple relapses of mantle cell lymphoma as different extranodal lesions: A case report. Med Int 5: 85, 2025.
APA
Manabe, M., Aohara, D., Mukai, D., Nanno, S., & Koh, K. (2025). Multiple relapses of mantle cell lymphoma as different extranodal lesions: A case report. Medicine International, 5, 85. https://doi.org/10.3892/mi.2025.284
MLA
Manabe, M., Aohara, D., Mukai, D., Nanno, S., Koh, K."Multiple relapses of mantle cell lymphoma as different extranodal lesions: A case report". Medicine International 5.6 (2025): 85.
Chicago
Manabe, M., Aohara, D., Mukai, D., Nanno, S., Koh, K."Multiple relapses of mantle cell lymphoma as different extranodal lesions: A case report". Medicine International 5, no. 6 (2025): 85. https://doi.org/10.3892/mi.2025.284
Copy and paste a formatted citation
x
Spandidos Publications style
Manabe M, Aohara D, Mukai D, Nanno S and Koh K: Multiple relapses of mantle cell lymphoma as different extranodal lesions: A case report. Med Int 5: 85, 2025.
APA
Manabe, M., Aohara, D., Mukai, D., Nanno, S., & Koh, K. (2025). Multiple relapses of mantle cell lymphoma as different extranodal lesions: A case report. Medicine International, 5, 85. https://doi.org/10.3892/mi.2025.284
MLA
Manabe, M., Aohara, D., Mukai, D., Nanno, S., Koh, K."Multiple relapses of mantle cell lymphoma as different extranodal lesions: A case report". Medicine International 5.6 (2025): 85.
Chicago
Manabe, M., Aohara, D., Mukai, D., Nanno, S., Koh, K."Multiple relapses of mantle cell lymphoma as different extranodal lesions: A case report". Medicine International 5, no. 6 (2025): 85. https://doi.org/10.3892/mi.2025.284
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