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Medicine International
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Print ISSN: 2754-3242 Online ISSN: 2754-1304
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March-April 2026 Volume 6 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review Open Access

Radiation‑induced alterations in the cancer microenvironment (Review)

  • Authors:
    • Haiying Liu
    • Xiaoping Zhu
    • Zhenxing He
    • Jianshe Yang

  • View Affiliations / Copyright

    Affiliations: Medical College, Hexi University, Zhangye, Gansu 734000, P.R. China, Department of General Surgery, The Third People's Hospital of Longgang District, Shenzhen and Shenzhen Clinical Medical School, Guangdong Pharmaceutical University, Shenzhen, Guangdong 518115, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 15
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    Published online on: January 23, 2026
       https://doi.org/10.3892/mi.2026.299
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Abstract

Radiation therapy is routinely used for the treatment of cancer; however, the development of radiation resistance in some tumor cells can lead to poor efficacy. Cancer cells can alter their metabolic status following exposure to radiation to reduce radiation‑induced cytotoxicity, ultimately enabling them to survive radiation injury and adapt to the changed environment. It has been indicated that these metabolic changes in cancer cells affect the cancer microenvironment, and certain metabolite changes within the microenvironment may, in turn, promote cancer cell proliferation. Therefore, combining radiotherapy with targeted metabolic treatments may enhance the effectiveness of cancer therapy. The present review discusses the metabolic reprogramming of cancer cells following radiotherapy, and the resulting microenvironmental metabolic characteristics. Furthermore, the present review introduces the novel findings on innate nano‑confinements, which may influence the cancer microenvironment by regulating energy metabolism and signaling pathways through new mechanisms.

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Copy and paste a formatted citation
Spandidos Publications style
Liu H, Zhu X, He Z and Yang J: <p>Radiation‑induced alterations in the cancer microenvironment (Review)</p>. Med Int 6: 15, 2026.
APA
Liu, H., Zhu, X., He, Z., & Yang, J. (2026). <p>Radiation‑induced alterations in the cancer microenvironment (Review)</p>. Medicine International, 6, 15. https://doi.org/10.3892/mi.2026.299
MLA
Liu, H., Zhu, X., He, Z., Yang, J."<p>Radiation‑induced alterations in the cancer microenvironment (Review)</p>". Medicine International 6.2 (2026): 15.
Chicago
Liu, H., Zhu, X., He, Z., Yang, J."<p>Radiation‑induced alterations in the cancer microenvironment (Review)</p>". Medicine International 6, no. 2 (2026): 15. https://doi.org/10.3892/mi.2026.299
Copy and paste a formatted citation
x
Spandidos Publications style
Liu H, Zhu X, He Z and Yang J: <p>Radiation‑induced alterations in the cancer microenvironment (Review)</p>. Med Int 6: 15, 2026.
APA
Liu, H., Zhu, X., He, Z., & Yang, J. (2026). <p>Radiation‑induced alterations in the cancer microenvironment (Review)</p>. Medicine International, 6, 15. https://doi.org/10.3892/mi.2026.299
MLA
Liu, H., Zhu, X., He, Z., Yang, J."<p>Radiation‑induced alterations in the cancer microenvironment (Review)</p>". Medicine International 6.2 (2026): 15.
Chicago
Liu, H., Zhu, X., He, Z., Yang, J."<p>Radiation‑induced alterations in the cancer microenvironment (Review)</p>". Medicine International 6, no. 2 (2026): 15. https://doi.org/10.3892/mi.2026.299
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