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Acrokeratosis verruciformis of Hopf: Genetic, clinicopathologic and therapeutic features (Review)

  • Authors:
    • Konstantinos-Antonios Kostopoulos‑Kanitakis
    • Jean Kanitakis
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 69152 Pierre‑Bénite, France, Department of Dermatology/CliMA, Ed. Herriot Hospital (Pav. R), Hospices Civils de Lyon, 69437 Lyon cedex 03, France
    Copyright: © Kostopoulos‑Kanitakis et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 37
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    Published online on: May 12, 2026
       https://doi.org/10.3892/mi.2026.321
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Abstract

Acrokeratosis verruciformis of Hopf (AVH) is a rare genodermatosis belonging to the group of epidermal differentiation diseases. It is due to the heterozygous missense mutation p.(Pro602Leu) in the ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 (ATP2A2) gene, which is also involved in Darier disease (DD), and is therefore considered an allelic form of DD. AVH is usually transmitted as an autosomal dominant trait with variable penetrance, although several sporadic cases have been reported. The disease manifests clinically with flat, wart‑like papules with a verrucous surface that develop predominantly on the dorsum of the hands and feet, and appear early in life or, in sporadic cases, in adulthood. The lesions exhibit characteristic microscopic changes (verrucous epidermal hyperplasia with a ‘church‑spire‑like’ surface), which allow differentiation from DD. The course of the disease is chronic and the outcome as a rule benign, although rare cases of malignant transformation have been reported. Treatment is not necessary; it can be attempted at the request of the patient, knowing that no standardized treatment exists. Treatments that have been tested include topical agents (namely keratolytics, retinoids and cryotherapy) and systemic retinoids; however, the results are often modest. The present brief narrative review aimed to summarize the etiopathogenic, clinical, histopathological and therapeutic features of AVH.
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1 

Hopf G: Über eine nicht beschriebene disseminierte Keratose (Acrokeratosis Verruciformis). Dermatol Zeitschr. 60:227–250. 1931.(In German).

2 

Blanchet-Bardon C, Durand-Delorme M, Nazzaro V, Bédane C, Mariano A, Mimoz C and Puissant A: Hopf's acrokeratosis verruciformis or acral Darier's disease. Ann Dermatol Vénéréol. 115:1229–1232. 1988.PubMed/NCBI(In French).

3 

Ettinger M, Kimeswenger S, Deli I, Traxler J, Altrichter S, Noack P, Wikstrom JD, Guenova E and Hoetzenecker W: Darier disease: Current insights and challenges in pathogenesis and management. J Eur Acad Dermatol Venereol. 39:942–951. 2025.PubMed/NCBI View Article : Google Scholar

4 

Mathur M, Paudel S, Regmi S, Karki S, Maharjan S and Bhattarai N: Clinical overlap of Darier's disease and acrokeratosis verruciformis of Hopf: A case report. Clin Case Rep. 13(e70862)2025.PubMed/NCBI View Article : Google Scholar

5 

Herndon JH Jr and Wilson JD: Acrokeratosis verruciformis (Hopf) and Darier's disease: genetic evidence for a unitary origin. Arch Dermatol. 93:305–310. 1966.

6 

Paudel V, Pradhan MB, Shrestha B and Paudel S: Clinical and histopathologic findings in a patient with Darier-White disease with acrokeratosis verruciformis of Hopf. Case Rep Dermatol Med. 2022(5233837)2022.

7 

Verma J, Gopinath H, Josephain K, Bharti JN and Santosh T: Acrokeratosis verruciformis of Hopf in an adult-A rare case report with review of literature. Indian J Dermatol. 67:792–794. 2022.PubMed/NCBI View Article : Google Scholar

8 

Imtiaz S, Sadaf Ahmed Asim and Sharmeen Nasir: Co-Existence of Darier Disease and Acrokeratosis Verruciformis of HOPF. J Pak Assoc Dermatol [Internet] 35: 80-83. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/2756.

9 

Matsumoto A, Gregory N, Rady PL, Tyring SK and Carlson JA: Brief report: HPV-17 infection in Darier disease with acrokeratosis verrucosis of Hopf. Am J Dermatopathol. 39:370–373. 2017.PubMed/NCBI View Article : Google Scholar

10 

Piskin S, Saygin A, Doganay l, Kircuval D and Gurkan E: Coexistence of Darier's disease and acrokeratosis verruciformis of Hopf. Yonsei Med J. 45:956–959. 2004.PubMed/NCBI View Article : Google Scholar

11 

Bergman R, Sezin T, Indelman M, Helou WA and Avitan-Hersh E: Acrokeratosis verruciformis of Hopf showing P602L mutation in ATP2A2 and overlapping histopathological features with Darier disease. Am J Dermatopathol. 34:597–601. 2012.PubMed/NCBI View Article : Google Scholar

12 

Rajan MB, Bains A and Vedant D: Dermoscopy of acrokeratosis verruciformis of Hopf. Indian Dermatol Online J. 12:374–375. 2020.PubMed/NCBI View Article : Google Scholar

13 

Dhitavat J, Macfarlane S, Dode L, Leslie N, Sakuntabhai A, MacSween R, Saihan E and Hovnanian A: Acrokeratosis verruciformis of Hopf is caused by mutation in ATPA2: Evidence that it is allelic to Darier's disease. J Invest Dermatol. 120:229–232. 2003.PubMed/NCBI View Article : Google Scholar

14 

Ronan A, Ingrey A, Murray N and Chee P: Recurrent ATP2A2 p.(Pro602Leu) mutation differentiates Acrokeratosis verruciformis of Hopf from the allelic condition Darier disease. Am J Med Genet A. 173:1975–1978. 2017.PubMed/NCBI View Article : Google Scholar

15 

Wang PG, Gao M, Lin GS, Yang S, Lin D, Liang YH, Zhang GL, Zhu YG, Cui Y, Zhang KY, et al: Genetic heterogeneity in acrokeratosis of Hopf. Clin Exp Dermatol. 31:558–563. 2006.PubMed/NCBI View Article : Google Scholar

16 

Berk DR, Taube JM, Bruckner AL and Lane AT: A sporadic patient with acrokeratosis verruciformis of Hopf and a novel ATP2A2 mutation. Br J Dermatol. 163:653–654. 2010.PubMed/NCBI View Article : Google Scholar

17 

Torné Escasany R, López Gil F and Umbert Millet P: Hopf's acrokeratosis verruciformis. Communication of a non-familial case. Med Cutan Ibero Lat Am. 15:441–443. 1987.PubMed/NCBI(In Spanish).

18 

Santosh T and Patro MK: Non-familial acrokeratosis verruciformis of Hopf: A Rare Case Report. Int J Pathol Clin Res. 10(149)2024.

19 

Cabello-Hernández AI, Rodríguez-Rangel X, Polanco-llanes AS, Toussaint-Caire S and Domínguez-Cherit J: Sporadic case of acrokeratosis verruciformis of Hopf with unusual clinical presentation: A case report and review of the literature. Cureus. 17(e91671)2025.PubMed/NCBI View Article : Google Scholar

20 

Vakis G, Csató M, Kemény L, Korom I, Morvay M and Dobozy A: Hailey-Hailey disease with acrokeratosis verruciformis Hopf. Acta Derm Venereol. 76(157)1966.PubMed/NCBI View Article : Google Scholar

21 

Marill FG and Vodov I: Association of verruciform acrokeratosis with congenital poikiloderma as a dermatologic entity. Dermatologica. 156:351–357. 1978.PubMed/NCBI(In French).

22 

Vodov I: Coexistence of acrokeratosis verruciformis with epidermolysis bullosa. Rev Med Chir Soc Med Nat Iasi. 84:443–446. 1980.PubMed/NCBI(In French).

23 

Verbov J: Acrokeratosis verruciformis of Hopf with steatocystoma multiplex and hypertrophic lichen planus. Br J Dermatol. 85:91–94. 1972.PubMed/NCBI View Article : Google Scholar

24 

Farro P, Zalaudek I, Ferrara G, Fulgione E, Cicale l, Petrillo G, Zanchini R, Ruocco E and Argenziano G: Unusual association between acrokeratosis verruciformis of Hopf and multiple keratoacanthomas. Successful therapy with acitretin. J Dtsch Dermatol Ges. 2:440–442. 2004.PubMed/NCBI View Article : Google Scholar

25 

Humbert P, Laurent R, Faivre B and Agache P: Nevoid basal cell carcinoma syndrome and acrokeratosis verruciformis. Occurrence of two rare inherited autosomal dominant conditions in the same patient. Dermatologica. 180:169–170. 1990.PubMed/NCBI

26 

Banaszkiewicz H: A case of Darier's disease with lesions of acrokeratosis verruciformis of the Hopf-type in a father and son, with coexistence of psoriasis in the son. Przegl Dermatol. 55:781–786. 1968.PubMed/NCBI(In Polish).

27 

Defelice T, Robinson U, Patel R and Kamino H: Acrokeratosis verruciformis. Dermatol Online J. 18(12)2012.PubMed/NCBI

28 

Goswami A, Marak A, Verma S and Dey B: An atypical case of acrokeratosis verruciformis of Hopf responding to combined acitretin and cryotherapy. Cureus. 16(e60000)2024.PubMed/NCBI View Article : Google Scholar

29 

Kaliyadan F, Manoj J and Venkitakrishnan S: Acrokeratosis verruciformis of Hopf associated with dilated cardiomyopathy. Indian J Dermatol. 54:296–297. 2009.PubMed/NCBI View Article : Google Scholar

30 

Lim CE, Chia HY and Ho MSL: Multiple papules on the hands and limbs in an 18-year-old male. Pediatr Dermatol. 40:198–200. 2023.PubMed/NCBI View Article : Google Scholar

31 

Panja RK: Acrokeratosis verruciformis (Hopf): A clinical entity? Br J Dermatol. 96:643–652. 1977.PubMed/NCBI View Article : Google Scholar

32 

Bang CH, Kim HS, Park YM, Kim HO and Lee JY: Non-familial acrokeratosis verruciformis of Hopf. Ann Dermatol. 23 (Suppl 1):S61–S63. 2011.PubMed/NCBI View Article : Google Scholar

33 

Faina V, Magri F, Sernicola A, Chello C, Gagliostro N and Grieco T: Late-onset non-familial acrokeratosis verruciformis of Hopf: A case report. Clin Ter. 170:e418–e420. 2019.PubMed/NCBI View Article : Google Scholar

34 

Schueller WA: Acrokeratosis verruciformis of Hopf. Arch Dermatol. 106:81–83. 1972.PubMed/NCBI

35 

Nair PA: Acrokeratosis verruciformis of hopf along lines of blaschko. Indian J Dermatol. 58(406)2013.PubMed/NCBI View Article : Google Scholar

36 

Errichetti E: Acrokeratosis verruciformis of Hopf: Dermoscopic approach in lighter phototypes. J Eur Acad Dermatol Venereol. 37:e427–e428. 2023.PubMed/NCBI View Article : Google Scholar

37 

Behera B, Prabhakaran N, Naveed S, Kumari R, Thappa DM and Gochhait D: Dermoscopy of acrokeratosis verruciformis of Hopf. J Am Acad Dermatol. 77:e33–e35. 2017.PubMed/NCBI View Article : Google Scholar

38 

Ranjan E, Sandhu S and Sharma AS: Acrokeratosis verruciformis of Hopf: A series of 3 cases with clinical, histopathological and dermoscopic features. Indian J Dermatol. 68(489)2023.PubMed/NCBI View Article : Google Scholar

39 

Llamas-Molina JM, de la Torre-Gomar FJ, Carrero-Castaño A, Gil-Villalba A, Prados-Carmona A and Ruiz-Villaverde R: Acrokeratosis verruciformis of Hopf: Dermoscopy approach in dark skin patients. J Eur Acad Dermatol Venereol. 36:e944–e945. 2022.PubMed/NCBI View Article : Google Scholar

40 

Rallis E, Economidi A, Papadakis P and Verros C: Acrokeratosis verruciformis of Hopf (Hopf disease): Case report and review of the literature. Dermatol Online J. 11(10)2005.PubMed/NCBI

41 

Singh G, Goswami P, Pathania Y and Pate T: Acrokeratosis verruciformis of Hopf: A rare presentation in a young Indian female-A case report and review. J Family Med Prim Care. 14:1125–1127. 2025.PubMed/NCBI View Article : Google Scholar

42 

Dogliotti M and Schmaman A: Acrokeratosis verruciformis: Malignant transformation. Dermatologica. 143:95–99. 1971.PubMed/NCBI View Article : Google Scholar

43 

Andrade TC, Silva GV, Silva TM, Pinto AC, Nunes AJ and Martelli AC: Acrokeratosis verruciformis of Hopf - Case report. An Bras Dermatol. 91:639–641. 2016.PubMed/NCBI View Article : Google Scholar

44 

Harman M, Durdu M and Ibiloğlu I: Acrokeratosis verruciformis of Hopf exhibiting Darier disease-like cytological features. Clin Exp Dermatol. 41:761–763. 2016.PubMed/NCBI View Article : Google Scholar

45 

Serarslan G, Balci DD and Homan S: Acitretin treatment in acrokeratosis verruciformis of Hopf. J Dermatol Treat. 18:123–125. 2007.PubMed/NCBI View Article : Google Scholar

46 

Lohanee K and Thapa DP: Acrokeratosis verruciformis of Hopf: an unusual presentation. Indian Dermatol Online J. 12:928–929. 2021.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Kostopoulos‑Kanitakis K and Kanitakis J: Acrokeratosis verruciformis of Hopf: Genetic, clinicopathologic and therapeutic features (Review). Med Int 6: 37, 2026.
APA
Kostopoulos‑Kanitakis, K., & Kanitakis, J. (2026). Acrokeratosis verruciformis of Hopf: Genetic, clinicopathologic and therapeutic features (Review). Medicine International, 6, 37. https://doi.org/10.3892/mi.2026.321
MLA
Kostopoulos‑Kanitakis, K., Kanitakis, J."Acrokeratosis verruciformis of Hopf: Genetic, clinicopathologic and therapeutic features (Review)". Medicine International 6.4 (2026): 37.
Chicago
Kostopoulos‑Kanitakis, K., Kanitakis, J."Acrokeratosis verruciformis of Hopf: Genetic, clinicopathologic and therapeutic features (Review)". Medicine International 6, no. 4 (2026): 37. https://doi.org/10.3892/mi.2026.321
Copy and paste a formatted citation
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Spandidos Publications style
Kostopoulos‑Kanitakis K and Kanitakis J: Acrokeratosis verruciformis of Hopf: Genetic, clinicopathologic and therapeutic features (Review). Med Int 6: 37, 2026.
APA
Kostopoulos‑Kanitakis, K., & Kanitakis, J. (2026). Acrokeratosis verruciformis of Hopf: Genetic, clinicopathologic and therapeutic features (Review). Medicine International, 6, 37. https://doi.org/10.3892/mi.2026.321
MLA
Kostopoulos‑Kanitakis, K., Kanitakis, J."Acrokeratosis verruciformis of Hopf: Genetic, clinicopathologic and therapeutic features (Review)". Medicine International 6.4 (2026): 37.
Chicago
Kostopoulos‑Kanitakis, K., Kanitakis, J."Acrokeratosis verruciformis of Hopf: Genetic, clinicopathologic and therapeutic features (Review)". Medicine International 6, no. 4 (2026): 37. https://doi.org/10.3892/mi.2026.321
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