|
1
|
Yang L, Zheng B and Gong Y: Global,
regional and national burden of ischemic heart disease and its
Attributable risk factors from 1990 to 2021: A systematic analysis
of the Global Burden of Disease study 2021. BMC Cardiovasc Disord.
25(625)2025.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Prabhu SD and Frangogiannis NG: The
biological basis for cardiac repair after myocardial infarction:
From inflammation to fibrosis. Circ Res. 119:91–112.
2016.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Derks W, Rode J, Collin S, Rost F, Heinke
P, Hariharan A, Pickel L, Simonova I, Lázár E, Graham E, et al: A
latent cardiomyocyte regeneration potential in human heart disease.
Circulation. 151:245–256. 2025.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Hwang HY, Yeom SY, Park EA, Lee W, Jang MJ
and Kim KB: Serial cardiac magnetic resonance imaging after
surgical coronary revascularization for left ventricular
dysfunction. J Thorac Cardiovasc Surg. 159:1798–1805.
2020.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Cao J, Dong R, Zhang K and Zhang H:
Effects of myocardial viability and left ventricular remodeling on
survival of patients with heart failure and reduced ejection
fraction after coronary artery bypass grafting. Cardiovasc Diagn
Ther. 10:183–192. 2020.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Nakae M, Kainuma S, Toda K, Miyagawa S,
Yoshikawa Y, Hata H, Yoshioka D, Kawamura T, Kawamura A, Kashiyama
N, et al: Incidence, determinants and clinical impact of left
ventricular function recovery after surgical treatments for
ischaemic cardiomyopathy. Eur J Cardiothorac Surg. 60:689–696.
2021.PubMed/NCBI View Article : Google Scholar
|
|
7
|
He X and Liu S, Zhang Z, Liu Q, Dong J,
Lin Z, Chen J, Li L, Liu W and Liu S and Liu S: M1
macrophage-derived exosomes inhibit cardiomyocyte proliferation
through delivering miR-155. BMC Cardiovasc Disord.
24(365)2024.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Hsiao LC, Lin YN, Shyu WC, Ho M, Lu CR,
Chang SS, Wang YC, Chen JY, Lu SY, Wu MY, et al: First-in-human
pilot trial of combined intracoronary and intravenous mesenchymal
stem cell therapy in acute myocardial infarction. Front Cardiovasc
Med. 9(961920)2022.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Noda T, Nishigaki K and Minatoguchi S:
Safety and efficacy of human Muse cell-based product for acute
myocardial infarction in a first-in-human trial. Circ J.
84:1189–1192. 2020.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Lyon AR, Babalis D, Morley-Smith AC,
Hedger M, Suarez Barrientos A, Foldes G, Couch LS, Chowdhury RA,
Tzortzis KN, Peters NS, et al: Investigation of the safety and
feasibility of AAV1/SERCA2a gene transfer in patients with chronic
heart failure supported with a left ventricular assist device-the
SERCA-LVAD TRIAL. Gene Ther. 27:579–590. 2020.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Aries A, Vignon C, Zanetti C, Goubaud A,
Cormier A, Diederichs A, Lahlil R, Hénon P and Garitaonandia I:
Development of a potency assay for CD34+ cell-based therapy. Sci
Rep. 13(19665)2023.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Chan JL, Miller JG, Zhou Y, Robey PG,
Stroncek DF, Arai AE, Sachdev V and Horvath KA: Intramyocardial
bone marrow stem cells in patients undergoing cardiac surgical
revascularization. Ann Thorac Surg. 109:1142–1149. 2020.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Abouzid MR, Umer AM, Jha SK, Akbar UA,
Khraisat O, Saleh A, Mohamed K, Esteghamati S and Kamel I: Stem
cell therapy for myocardial infarction and heart failure: A
comprehensive systematic review and critical analysis. Cureus.
16(e59474)2024.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Meng H, Cheng W, Wang L, Chen S, Teng Y,
Lu Z, Li Y and Zhao M: Mesenchymal stem cell exosomes in the
treatment of myocardial infarction: A systematic review of
preclinical in vivo studies. J Cardiovasc Transl Res. 15:317–339.
2022.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Yahyazadeh R, Baradaran Rahimi V and
Askari VR: Stem cell and exosome therapies for regenerating damaged
myocardium in heart failure. Life Sci. 351(122858)2024.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Hare JM: Bone marrow-derived mesenchymal
stem cells for heart failure with reduced ejection fraction. JAMA.
306:2156–2157. 2011.
|
|
17
|
Xiong YY, Gong ZT, Tang RJ and Yang YJ:
The pivotal roles of exosomes derived from endogenous immune cells
and exogenous stem cells in myocardial repair after acute
myocardial infarction. Theranostics. 11:1046–1058. 2021.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Yu H, Lu K, Zhu J and Wang J: Stem cell
therapy for ischemic heart diseases. Br Med Bull. 121:135–154.
2017.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Wu R, Hu X and Wang J: Current optimized
strategies for stem cell-derived extracellular vesicle/exosomes in
cardiac repair. J Mol Cell Cardiol. 184:13–25. 2023.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Shazly T, Smith A, Uline MJ and Spinale
FG: Therapeutic payload delivery to the myocardium: Evolving
strategies and obstacles. JTCVS Open. 10:185–194. 2022.PubMed/NCBI View Article : Google Scholar
|
|
21
|
de Jong R, Houtgraaf JH, Samiei S, Boersma
E and Duckers HJ: Intracoronary stem cell infusion after acute
myocardial infarction: A meta-analysis and update on clinical
trials. Circ Cardiovasc Interv. 7:156–167. 2014.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Mathur A, Fernández-Avilés F, Bartunek J,
Belmans A, Crea F, Dowlut S, Galiñanes M, Good MC, Hartikainen J,
Hauskeller C, et al: The effect of intracoronary infusion of bone
marrow-derived mononuclear cells on all-cause mortality in acute
myocardial infarction: The BAMI trial. Eur Heart J. 41:3702–3710.
2020.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Attar A, Bahmanzadegan Jahromi F, Kavousi
S, Monabati A and Kazemi A: Mesenchymal stem cell transplantation
after acute myocardial infarction: A meta-analysis of clinical
trials. Stem Cell Res Ther. 12(600)2021.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Botleroo RA, Bhandari R, Ahmed R, Kareem
R, Gyawali M, Venkatesan N, Ogeyingbo OD and Elshaikh AO: Stem cell
therapy for the treatment of myocardial infarction: How far are we
now? Cureus. 13(e17022)2021.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Ramireddy A, Brodt CR, Mendizabal AM,
DiFede DL, Healy C, Goyal V, Alansari Y, Coffey JO, Viles-Gonzalez
JF, Heldman AW, et al: Effects of transendocardial stem cell
injection on ventricular proarrhythmia in patients with ischemic
cardiomyopathy: Results from the POSEIDON and TAC-HFT trials. Stem
Cells Transl Med. 6:1366–1372. 2017.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Chugh AR, Beache GM, Loughran JH, Mewton
N, Elmore JB, Kajstura J, Pappas P, Tatooles A, Stoddard MF, Lima
JA, et al: Administration of cardiac stem cells in patients with
ischemic cardiomyopathy: The SCIPIO trial: Surgical aspects and
interim analysis of myocardial function and viability by magnetic
resonance. Circulation. 126 (Suppl 11):S54–S64. 2012.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Makkar RR, Smith RR, Cheng K, Malliaras K,
Thomson LE, Berman D, Czer LS, Marbán L, Mendizabal A, Johnston PV,
et al: Intracoronary cardiosphere-derived cells for heart
regeneration after myocardial infarction (CADUCEUS): A prospective,
randomised phase 1 trial. Lancet. 379:895–904. 2012.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Yacoub MH and Terrovitis J: CADUCEUS,
SCIPIO, ALCADIA: Cell therapy trials using cardiac-derived cells
for patients with post myocardial infarction LV dysfunction, still
evolving. Glob Cardiol Sci Pract. 2013:5–8. 2013.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Karantalis V, DiFede DL, Gerstenblith G,
Pham S, Symes J, Zambrano JP, Fishman J, Pattany P, McNiece I,
Conte J, et al: Autologous mesenchymal stem cells produce
concordant improvements in regional function, tissue perfusion, and
fibrotic burden when administered to patients undergoing coronary
artery bypass grafting: The Prospective Randomized Study of
Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac
Surgery (PROMETHEUS) trial. Circ Res. 114:1302–1310.
2014.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Bolli R, Mitrani RD, Hare JM, Pepine CJ,
Perin EC, Willerson JT, Traverse JH, Henry TD, Yang PC, Murphy MP,
et al: Cardiovascular Cell Therapy Research Network (CCTRN). A
Phase II study of autologous mesenchymal stromal cells and c-kit
positive cardiac cells, alone or in combination, in patients with
ischaemic heart failure: the CCTRN CONCERT-HF trial. Eur J Heart
Fail. 23:661–674. 2021.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Borow KM, Yaroshinsky A, Greenberg B and
Perin EC: Phase 3 DREAM-HF trial of mesenchymal precursor cells in
chronic heart failure. Circ Res. 125:265–281. 2019.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Delewi R, Hirsch A, Tijssen JG,
Schächinger V, Wojakowski W, Roncalli J, Aakhus S, Erbs S, Assmus
B, Tendera M, et al: Impact of intracoronary bone marrow cell
therapy on left ventricular function in the setting of ST-segment
elevation myocardial infarction: A collaborative meta-analysis. Eur
Heart J. 35:989–998. 2014.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Martínez-Falguera D, Iborra-Egea O and
Gálvez-Montón C: iPSC therapy for myocardial infarction in large
animal models: Land of hope and dreams. Biomedicines.
9(1836)2021.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Vo QD, Saito Y, Nakamura K, Iida T and
Yuasa S: Induced pluripotent stem cell-derived cardiomyocytes
therapy for ischemic heart disease in animal models: A
meta-analysis. Int J Mol Sci. 25(987)2024.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Menasché P: Cell therapy with human
ESC-derived cardiac cells: Clinical perspectives. Front Bioeng
Biotechnol. 8(601560)2020.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Li J, Liu L, Zhang J, Qu X, Kawamura T,
Miyagawa S and Sawa Y: Engineered tissue for cardiac regeneration:
Current status and future perspectives. Bioengineering (Basel).
9(605)2022.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Sugiura T, Shahannaz DC and Ferrell BE:
Current status of cardiac regenerative therapy using induced
pluripotent stem cells. Int J Mol Sci. 25(5772)2024.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Khan K, Caron C, Mahmoud I, Derish I,
Schwertani A and Cecere R: Extracellular vesicles as a cell-free
therapy for cardiac repair: A systematic review and meta-analysis
of randomized controlled preclinical trials in animal myocardial
infarction models. Stem Cell Rev Rep. 18:1143–1167. 2022.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Ghassemi K, Inouye K, Takhmazyan T,
Bonavida V, Yang JW, de Barros NR and Thankam FG: Engineered
vesicles and hydrogel technologies for myocardial regeneration.
Gels. 9(824)2023.PubMed/NCBI View Article : Google Scholar
|
|
40
|
McDonald CM, Marbán E, Hendrix S, Hogan N,
Ruckdeschel Smith R, Eagle M, Finkel RS, Tian C, Janas J, Harmelink
MM, et al: Repeated intravenous cardiosphere-derived cell therapy
in late-stage Duchenne muscular dystrophy (HOPE-2): A multicentre,
randomised, double-blind, placebo-controlled, phase 2 trial.
Lancet. 399:1049–1058. 2022.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Shahannaz DC, Sugiura T, Ferrell BE and
Yoshida T: Arrhythmogenic risk in iPSC-derived cardiomyocytes:
Current limitations and therapeutic perspectives. Medicina.
61(2056)2025.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Huang S, Yang Y, Yang Q, Zhao Q and Ye X:
Engineered circulatory scaffolds for building cardiac tissue. J
Thorac Dis. 10 (Suppl 20):S2312–S2328. 2018.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Liu T, Hao Y, Zhang Z, Zhou H, Peng S,
Zhang D, Li K, Chen Y and Chen M: Advanced cardiac patches for the
treatment of myocardial infarction. Circulation. 149:2002–2020.
2024.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Nguyen-Truong M, Li Y and Wang Z:
Mechanical considerations of electrospun scaffolds for myocardial
tissue and regenerative engineering. Bioengineering.
7(122)2020.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Augustine R, Dan P, Hasan A, Khalaf IM,
Prasad P, Ghosal K, Gentile C, McClements L and Maureira P: Stem
cell-based approaches in cardiac tissue engineering: Controlling
the microenvironment for autologous cells. Biomed Pharmacother.
138(111425)2021.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Tani H and Tohyama S: Human engineered
heart tissue models for disease modeling and drug discovery. Front
Cell Dev Biol. 10(855763)2022.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Zhu D, Li Z, Huang K, Caranasos TG, Rossi
JS and Cheng K: Minimally invasive delivery of therapeutic agents
by hydrogel injection into the pericardial cavity for cardiac
repair. Nat Commun. 12(1412)2021.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Patel R and Patel D: Injectable hydrogels
in cardiovascular tissue engineering. Polymers.
16(1878)2024.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Zhou C, Xu Y and Guo Z: The application of
epicardium in heart failure treatment: Opportunities and
challenges. Int J Med Sci. 22:3946–3957. 2025.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Ghovvati M, Kharaziha M, Ardehali R and
Annabi N: Recent advances in designing electroconductive
biomaterials for cardiac tissue engineering. Adv Healthc Mater.
11(e2200055)2022.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Esmaeili H, Patino-Guerrero A, Hasany M,
Ansari MO, Memic A, Dolatshahi-Pirouz A and Nikkhah M:
Electroconductive biomaterials for cardiac tissue engineering. Acta
Biomater. 139:118–140. 2021.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Williams MAC, Mair DB, Lee W, Lee E and
Kim D: Engineering three-dimensional vascularized cardiac tissues.
Tissue Eng Part B Rev. 28:336–350. 2021.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Eliwa A, Abbas MKG and Al-Ejji M:
Advancing cardiac patch viability and functionality: Innovations in
scaffold design and cellular optimization. J Mater Sci Mater Med.
36(77)2025.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Zhang Y, Friec AL, Zhang Z, Müller CA, Du
T, Dong M, Liu Y and Chen M: Electroactive biomaterials synergizing
with electrostimulation for cardiac tissue regeneration and
function-monitoring. Mater Today. 70:237–272. 2023.
|
|
55
|
McMahan S, Taylor A, Copeland KM, Pan Z,
Liao J and Hong Y: Current advances in biodegradable synthetic
polymer based cardiac patches. J Biomed Mater Res A. 108:972–983.
2020.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Walker BW, Lara RP, Yu CH, Sani ES,
Kimball W, Joyce S and Annabi N: Engineering a naturally-derived
adhesive and conductive cardiopatch. Biomaterials. 207:89–101.
2019.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Cui H, Yu ZX, Huang Y, Hann SY, Esworthy
T, Shen YL and Zhang LG: 3D printing of thick myocardial tissue
constructs with anisotropic myofibers and perfusable vascular
channels. Biomater Adv. 153(213579)2023.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Udriște AS, Niculescu A, Iliuță L, Bajeu
T, Georgescu A, Grumezescu AM and Bădilă E: Progress in
biomaterials for cardiac tissue engineering and regeneration.
Polymers. 15(1177)2023.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Jones LS, Biefer HRC, Mekkattu M, Thijssen
Q, Amicone A, Bock A, Weisskopf M, Zorndt D, Meier D, Zheng L, et
al: Volumetric 3D printing and melt-electrowriting to fabricate
implantable reinforced cardiac tissue patches. Adv Mater.
37(e2504765)2025.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Tan Y, Chen Y, Lu T, Witman N, Yan B, Gong
Y, Ai X, Yang L, Liu M, Luo R, et al: Engineering a
conduction-consistent cardiac patch with rGO/PLCL electrospun
nanofibrous membranes and human iPSC-derived cardiomyocytes. Front
Bioeng Biotechnol. 11(1094397)2023.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Qiu R, Zhang X, Song C, Xu K, Nong H, Li
Y, Xing X, Mequanint K, Liu Q, Yuan Q, et al: E-cardiac patch to
sense and repair infarcted myocardium. Nat Commun.
15(4133)2024.PubMed/NCBI View Article : Google Scholar
|
|
62
|
Prat-Vidal C, Rodríguez-Gómez L, Aylagas
M, Nieto-Nicolau N, Gastelurrutia P, Agustí E, Gálvez-Montón C,
Jorba I, Teis A, Monguió-Tortajada M, et al: First-in-human
PeriCord cardiac bioimplant: Scalability and GMP manufacturing of
an allogeneic engineered tissue graft. EBioMedicine.
54(102729)2020.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Morales DL, Herrington C, Bacha EA, Morell
VO, Prodán Z, Mroczek T, Sivalingam S, Cox M, Bennink G and Asch
FM: A novel restorative pulmonary valve conduit: Early outcomes of
two clinical trials. Front Cardiovasc Med. 7(583360)2021.PubMed/NCBI View Article : Google Scholar
|
|
64
|
Bhatt A, Bates MJ, Marcu CB, Matheny RG,
Carabello BA, Yin K and Boyd WD: Second-generation extracellular
matrix patch for epicardial infarct repair. J Cardiothorac Surg.
18(255)2023.PubMed/NCBI View Article : Google Scholar
|
|
65
|
Goldman S, Traverse JH, Zile MR, Juneman
E, Greenberg B, Kelly RF, Koevary JW and Lancaster JJ: Perspective
on the development of a bioengineered patch to treat heart failure:
Rationale and proposed design of a phase I clinical trial. Vessel
Plus. 6(54)2022.
|
|
66
|
Roche CD, Iyer GR, Nguyen MH, Mabroora S,
Dome A, Sakr K, Pawar R, Lee V, Wilson CC and Gentile C: Cardiac
patch transplantation instruments for robotic minimally invasive
cardiac surgery: Initial proof-of-concept designs and surgery in a
porcine cadaver. Front Robotics AI. 8(714356)2022.PubMed/NCBI View Article : Google Scholar
|
|
67
|
Freystaetter K, Waterhouse BR, Chilvers N,
Trevis J, Ferguson J, Paul I and Dunning J: The importance of
culture change associated with novel surgical approaches and
innovation: Does perioperative care transcend technical
considerations for pulmonary lobectomy? Front Surg.
8(597410)2021.PubMed/NCBI View Article : Google Scholar
|
|
68
|
Lancaster JJ, Grijalva A, Fink J, Ref J,
Daugherty S, Whitman S, Fox K, Gorman G, Lancaster LD, Avery R, et
al: Biologically derived epicardial patch induces macrophage
mediated pathophysiologic repair in chronically infarcted swine
hearts. Commun Biol. 6(1203)2023.PubMed/NCBI View Article : Google Scholar
|
|
69
|
Chang T, Liu C, Yang H, Lu K, Han Y, Zheng
Y, Huang H, Wu Y, Song Y, Yu Q, et al: Fibrin-based cardiac patch
containing neuregulin-1 for heart repair after myocardial
infarction. Colloids Surf B Biointerfaces.
220(112936)2022.PubMed/NCBI View Article : Google Scholar
|
|
70
|
Jabbour RJ, Owen TJ, Pandey P, Reinsch M,
Wang B, King O, Couch LS, Pantou D, Pitcher DS, Chowdhury RA, et
al: In vivo grafting of large engineered heart tissue patches for
cardiac repair. JCI Insight. 6(e144068)2021.PubMed/NCBI View Article : Google Scholar
|
|
71
|
Rego A, Cheung PC, Harris WJ, Brady KM,
Newman J and Still R: Pericardial closure with extracellular matrix
scaffold following cardiac surgery associated with a reduction of
postoperative complications and 30-day hospital readmissions. J
Cardiothorac Surg. 14(61)2019.PubMed/NCBI View Article : Google Scholar
|
|
72
|
Sun M, LaSala VR, Giuglaris C, Blitzer D,
Jackman S, Ustunel S, Rajesh K and Kalfa D: Cardiovascular patches
applied in congenital cardiac surgery: Current materials and
prospects. Bioeng Transl Med. 10(e10706)2024.PubMed/NCBI View Article : Google Scholar
|
|
73
|
Hong SB, Jeong J and Choi H: Hydrogels in
cardiac surgery: Versatile platforms for tissue repair, adhesion
prevention, and localized therapeutics. Gels.
11(564)2025.PubMed/NCBI View Article : Google Scholar
|
|
74
|
Tao Z, Jarrell DK, Robinson A,
Cosgriff-Hernandez EM and Jacot JG: A prevascularized
polyurethane-reinforced fibrin patch improves regenerative
remodeling in a rat right ventricle replacement model. Adv Healthc
Mater. 10(e2101018)2021.PubMed/NCBI View Article : Google Scholar
|
|
75
|
Wang X, Wang H, Liu X, Zhang Y, Li J, Liu
H, Feng J, Jiang W, Liu L, Chen Y, et al: Self-adhesion conductive
cardiac patch based on methoxytriethylene glycol-functionalized
graphene effectively improves cardiac function after myocardial
infarction. J Adv Res. 76:745–759. 2024.PubMed/NCBI View Article : Google Scholar
|
|
76
|
Qian B, Shen A, Huang S, Shi H, Long Q,
Zhong Y, Qi Z, He X, Zhang Y, Hai W, et al: An intrinsically
magnetic epicardial patch for rapid vascular reconstruction and
drug delivery. Adv Sci. 10(e2303033)2023.PubMed/NCBI View Article : Google Scholar
|
|
77
|
Lee SH, Lee JW, Kim D, Cha GD and Sunwoo
S: Recent achievements of epicardial patch electronics using
adhesive and conductive hydrogels. Gels. 11(530)2025.PubMed/NCBI View Article : Google Scholar
|
|
78
|
Shan M, Wei L, Yang Z, Li Y, Deng R, Zhao
X, Wang F, Wang G, Wang L and Mao J: An anisotropic cardiac patch
with barbed microneedles for enhanced tissue anchorage and
myocardial repair. Acta Biomater. 205:505–520. 2025.PubMed/NCBI View Article : Google Scholar
|
|
79
|
Jebran AF, Seidler T, Tiburcy M, Daskalaki
M, Kutschka I, Fujita B, Ensminger S, Bremmer F, Moussavi A, Yang
H, et al: Engineered heart muscle allografts for heart repair in
primates and humans. Nature. 639:503–511. 2025.PubMed/NCBI View Article : Google Scholar
|
|
80
|
Zhu D, Hou J, Qian M, Jin D, Hao T, Pan Y,
Wang H, Wu S, Liu S, Wang F, et al: Nitrate-functionalized patch
confers cardioprotection and improves heart repair after myocardial
infarction via local nitric oxide delivery. Nat Commun.
12(4501)2021.PubMed/NCBI View Article : Google Scholar
|
|
81
|
Salerno N, Di Costanzo A, Marino F,
Scalise M, Leo I, Sabatino J, Canino G, Leccia A, De Angelis A,
Urbanek K, et al: Echocardiographic assessment of cardiac function
in mouse models of heart disease. Int J Mol Sci.
26(5995)2025.PubMed/NCBI View Article : Google Scholar
|
|
82
|
Korpela H, Järveläinen N, Siimes S,
Lampela J, Airaksinen J, Valli K, Turunen M, Pajula J, Nurro J and
Ylä-Herttuala S: Gene therapy for ischaemic heart disease and heart
failure. J Intern Med. 290:567–582. 2021.PubMed/NCBI View Article : Google Scholar
|
|
83
|
Evers MJ, Du W, Yang Q, Kooijmans SA, Vink
A, Van Steenbergen M, Vader P, de Jager SCA, Fuchs SA,
Mastrobattista E, et al: Delivery of modified mRNA to damaged
myocardium by systemic administration of lipid nanoparticles. J
Control Release. 343:207–216. 2022.PubMed/NCBI View Article : Google Scholar
|
|
84
|
Vekstein AM, Wendell DC, DeLuca S, Yan R,
Chen Y, Bishawi M, Devlin GW, Asokan A, Poss KD, Bowles DE, et al:
Targeted delivery for cardiac regeneration: Comparison of
intracoronary infusion and intramyocardial injection in porcine
hearts. Front Cardiovasc Med. 9(833335)2022.PubMed/NCBI View Article : Google Scholar
|
|
85
|
Roncalli J, Roubille F, Meyer N, Pompilio
G, Leroux L, Henon P, Trebuchet G, Criquet A, de Kalbermatten M,
Saloux E, et al: Transendocardial injection of expanded autologous
CD34+ cells after myocardial infarction: Design of the EXCELLENT
trial. ESC Heart Fail. 12:1455–1463. 2024.PubMed/NCBI View Article : Google Scholar
|
|
86
|
Anttila V, Saraste A, Knuuti J, Hedman M,
Jaakkola P, Laugwitz KL, Krane M, Jeppsson A, Sillanmäki S,
Rosenmeier J, et al: Direct intramyocardial injection of VEGF mRNA
in patients undergoing coronary artery bypass grafting. Mol Ther.
31:866–874. 2023.PubMed/NCBI View Article : Google Scholar
|
|
87
|
Jaski BE, Jessup ML, Mancini DM, Cappola
TP, Pauly DF, Greenberg B, Borow K, Dittrich H, Zsebo KM and Hajjar
RJ: Calcium Up-Regulation by Percutaneous Administration of Gene
Therapy In Cardiac Disease (CUPID) Trial Investigators. Calcium
upregulation by percutaneous administration of gene therapy in
cardiac disease (CUPID): A first-in-human phase 1/2 clinical trial.
J Card Fail. 15:171–181. 2009.PubMed/NCBI View Article : Google Scholar
|
|
88
|
Jessup M, Greenberg B, Mancini D, Cappola
T, Pauly DF, Jaski B, Yaroshinsky A, Zsebo KM, Dittrich H and
Hajjar RJ: Calcium Upregulation by Percutaneous Administration of
Gene Therapy in Cardiac Disease (CUPID) Investigators. Calcium
upregulation by percutaneous administration of gene therapy in
cardiac disease (CUPID): A phase 2 trial of intracoronary gene
therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with
advanced heart failure. Circulation. 124:304–313. 2011.PubMed/NCBI View Article : Google Scholar
|
|
89
|
Greenberg B, Butler J, Felker GM,
Ponikowski P, Voors AA, Desai AS, Barnard D, Bouchard A, Jaski B,
Lyon AR, et al: Calcium upregulation by percutaneous administration
of gene therapy in patients with cardiac disease (CUPID 2): A
randomized, multinational, double-blind, placebo-controlled, phase
2b trial. Lancet. 387:1178–1186. 2016.PubMed/NCBI View Article : Google Scholar
|
|
90
|
Shooshtarian AK, O'Gallagher K, Shah AM
and Zhang M: SERCA2a dysfunction in the pathophysiology of heart
failure with preserved ejection fraction: A direct role is yet to
be established. Heart Fail Rev. 30:545–564. 2025.PubMed/NCBI View Article : Google Scholar
|
|
91
|
Sasaki N, Kok CY, Westhaus A, Alexander
IE, Lisowski L and Kizana E: In search of Adeno-Associated virus
vectors with enhanced cardiac tropism for gene therapy. Heart Lung
Circ. 32:816–824. 2023.PubMed/NCBI View Article : Google Scholar
|
|
92
|
Henry TD, Chung ES, Alvisi M, Sethna F,
Murray DR, Traverse JH, Roessig L, Roberts L, Reddy S, Chen Y, et
al: Cardiotropic AAV gene therapy for heart failure: A phase 1
trial. Nat Med. 31:3845–3852. 2025.PubMed/NCBI View Article : Google Scholar
|
|
93
|
Kim H, Mun D, Kang JY, Lee SH, Yun N and
Joung B: Improved cardiac-specific delivery of RAGE siRNA within
small extracellular vesicles engineered to express intense cardiac
targeting peptide attenuates myocarditis. Mol Ther Nucleic Acids.
24:1024–1032. 2021.PubMed/NCBI View Article : Google Scholar
|
|
94
|
Ma XR, Yan TM, Pan Y and Jiang ZH:
Optimization of siRNA therapeutics targeting MIAT for
cardioprotection in myocardial ischemia/reperfusion injury. Mol
Ther Nucleic Acids. 36(102747)2025.PubMed/NCBI View Article : Google Scholar
|
|
95
|
Li Q, Yin K, Ma HP, Liu HH, Li S, Luo X,
Hu R, Zhang WW, Lv ZS, Niu XL, et al: Application of improved
GalNAc conjugation in development of cost-effective siRNA therapies
targeting cardiovascular diseases. Mol Ther. 32:637–645.
2024.PubMed/NCBI View Article : Google Scholar
|
|
96
|
Zhang S, Zhang Y, Duan X, Wang B and Zhan
Z: Targeting NPM1 epigenetically promotes postinfarction cardiac
repair by reprogramming reparative macrophage metabolism.
Circulation. 149:1982–2001. 2024.PubMed/NCBI View Article : Google Scholar
|
|
97
|
Zhao M, Wang DD, Liu X and Tian R:
Metabolic modulation of macrophage function post myocardial
infarction. Front Physiol. 11(674)2020.PubMed/NCBI View Article : Google Scholar
|
|
98
|
Meng C, Tao S, Li Y, Li J, Huang X, Xia X
and Liu Y: Efferocytosis in myocardial infarction: The regulatory
core from inflammation resolution to cardiac repair. Front Immunol.
17(1782933)2026.PubMed/NCBI View Article : Google Scholar
|
|
99
|
Gareri C, Polimeni A, Giordano S, Tammè L,
Curcio A and Indolfi C: Antisense oligonucleotides and small
interfering RNA for the treatment of dyslipidemias. J Clin Med.
11(3884)2022.PubMed/NCBI View Article : Google Scholar
|
|
100
|
Magadum A: Modified mRNA therapeutics for
heart diseases. Int J Mol Sci. 23(15514)2022.PubMed/NCBI View Article : Google Scholar
|
|
101
|
Ma C, Peng P, Zhou Y, Liu T, Wang L and Lu
C: MicroRNA-93 promotes angiogenesis and attenuates remodeling via
inactivation of the Hippo/Yap pathway by targeting Lats2 after
myocardial infarctionω. Mol Med Rep. 22:483–493. 2020.PubMed/NCBI View Article : Google Scholar
|
|
102
|
Yang P, Lou Y, Geng Z, Guo Z, Wu S, Li Y,
Song K, Shi T, Zhang S, Xiong J, et al: Allele-specific suppression
of variant MHC with high-precision RNA nuclease CRISPR-Cas13d
prevents hypertrophic cardiomyopathy. Circulation. 150:283–298.
2024.PubMed/NCBI View Article : Google Scholar
|
|
103
|
Mia MM, Cibi DM, Abdul Ghani SAB, Song W,
Tee N, Ghosh S, Mao J, Olson EN and Singh MK: YAP/TAZ deficiency
reprograms macrophage phenotype and improves infarct healing and
cardiac function after myocardial infarction. PLoS Biol.
18(e3000941)2020.PubMed/NCBI View Article : Google Scholar
|
|
104
|
Moradi A, Khoshniyat S, Nzeako T, Tabari
MAK, Olanisa OO, Tabbaa K, Alkowati H, Askarianfard M, Daoud D,
Oyesanmi O, et al: The future of clustered regularly interspaced
short palindromic repeats (CRISPR)-Cas9 gene therapy in
cardiomyopathies: A review of its therapeutic potential and
emerging applications. Cureus. 17(e79372)2025.PubMed/NCBI View Article : Google Scholar
|
|
105
|
Brown AM, Blind J, Campbell K and Ghosh S:
Safeguards for using viral vector systems in human gene therapy: A
resource for biosafety professionals mitigating risks in health
care settings. Appl Biosaf. 25:184–193. 2020.PubMed/NCBI View Article : Google Scholar
|
|
106
|
Blind JE, McLeod EN, Brown A, Patel H and
Ghosh S: Biosafety practices for in vivo viral-mediated gene
therapy in the health care setting. Appl Biosaf. 25:194–200.
2020.PubMed/NCBI View Article : Google Scholar
|
|
107
|
Eisenman D and Swindle S: FDA guidance on
shedding and environmental impact in clinical trials involving gene
therapy products. Appl Biosaf. 27:191–197. 2022.PubMed/NCBI View Article : Google Scholar
|
|
108
|
Vrellaku B, Sethw Hassan I, Howitt R,
Webster CP, Harriss E, McBlane F, Betts C, Schettini J, Lion M,
Mindur JE, et al: A systematic review of immunosuppressive
protocols used in AAV gene therapy for monogenic disorders. Mol
Ther. 32:3220–3259. 2024.PubMed/NCBI View Article : Google Scholar
|
|
109
|
Lowdell MW: Considerations for
manufacturing of cell and gene medicines for clinical development.
Cytotherapy. 27:874–883. 2025.PubMed/NCBI View Article : Google Scholar
|
|
110
|
Bouabdallaoui N, Tardif JC, Waters DD,
Pinto FJ, Maggioni AP, Diaz R, Berry C, Koenig W, Lopez-Sendon J,
Gamra H, et al: Time-to-treatment initiation of colchicine and
cardiovascular outcomes after myocardial infarction in the
Colchicine Cardiovascular Outcomes Trial (COLCOT). Eur Heart J.
41:4092–4099. 2020.PubMed/NCBI View Article : Google Scholar
|
|
111
|
Everett BM, MacFadyen JG, Thuren T, Libby
P, Glynn RJ and Ridker PM: Inhibition of interleukin-1β and
reduction in atherothrombotic cardiovascular events in the CANTOS
trial. J Am Coll Cardiol. 76:1660–1670. 2020.PubMed/NCBI View Article : Google Scholar
|
|
112
|
Yang D, Liu HQ, Liu FY, Tang N, Guo Z, Ma
SQ, An P, Wang MY, Wu HM, Yang Z, et al: The roles of
noncardiomyocytes in cardiac remodeling. Int J Biol Sci.
16:2414–2429. 2020.PubMed/NCBI View Article : Google Scholar
|
|
113
|
Lewis GA, Dodd S, Clayton D, Bedson E,
Eccleson H, Schelbert EB, Naish JH, Jimenez BD, Williams SG,
Cunnington C, et al: Pirfenidone in heart failure with preserved
ejection fraction: A randomized phase 2 trial. Nat Med.
27:1477–1482. 2021.PubMed/NCBI View Article : Google Scholar
|
|
114
|
Lewis GA, Rosala-Hallas A, Dodd S,
Schelbert EB, Williams SG, Cunnington C, McDonagh T and Miller CA:
Characteristics associated with Growth differentiation factor 15 in
heart failure with preserved ejection fraction and the impact of
pirfenidone. J Am Heart Assoc. 11(e024668)2022.PubMed/NCBI View Article : Google Scholar
|
|
115
|
von Lewinski D, Kolesnik E, Tripolt NJ,
Pferschy PN, Benedikt M, Wallner M, Alber H, Berger R, Lichtenauer
ML, Saely CH, et al: Empagliflozin in acute myocardial infarction:
The EMMY trial. Eur Heart J. 43:4421–4432. 2022.PubMed/NCBI View Article : Google Scholar
|
|
116
|
Biegus J, Voors AA, Collins SP, Kosiborod
MN, Teerlink JR, Angermann CE, Tromp J, Ferreira JP, Nassif ME,
Psotka MA, et al: Impact of empagliflozin on decongestion in acute
heart failure: The EMPULSE trial. Eur Heart J. 44:41–50.
2023.PubMed/NCBI View Article : Google Scholar
|
|
117
|
Chatfield KC, Sparagna GC, Chau S,
Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC,
Miyamoto SD and Stauffer BL: Elamipretide improves mitochondrial
function in the failing human heart. JACC Basic Transl Sci.
4:147–157. 2019.PubMed/NCBI View Article : Google Scholar
|
|
118
|
Nassiri S, Van de Bovenkamp AA,
Remmelzwaal S, Sorea O, de Man F and Handoko ML: Effects of
trimetazidine on heart failure with reduced ejection fraction and
associated clinical outcomes: A systematic review and
meta-analysis. Open Heart. 11(e002579)2024.PubMed/NCBI View Article : Google Scholar
|
|
119
|
Sisakian HS, Muradyan NA, Babayan AV,
Sargsyan LA, Shamyar SA, Chopikyan AS and Shahnazaryan SA:
Metabolic intervention with trimetazidine improves intracardiac
hemodynamics and reduces re-hospitalizations in patients with
advanced heart failure. Am J Cardiovasc Dis. 15:13–20.
2025.PubMed/NCBI View Article : Google Scholar
|
|
120
|
Owens WA, Walaszczyk A, Spyridopoulos I,
Dookun E and Richardson GD: Senescence and senolytics in
cardiovascular disease: Promise and potential pitfalls. Mech Ageing
Dev. 198(111540)2021.PubMed/NCBI View Article : Google Scholar
|
|
121
|
Soto-Gamez A, Quax WJ and Demaria M:
Regulation of survival networks in senescent cells: From mechanisms
to interventions. J Mol Biol. 431:2629–2643. 2019.PubMed/NCBI View Article : Google Scholar
|
|
122
|
En A, Takauji Y, Ayusawa D and Fujii M:
The role of lamin B receptor in the regulation of
senescence-associated secretory phenotype (SASP). Exp Cell Res.
390(111927)2020.PubMed/NCBI View Article : Google Scholar
|
|
123
|
Anderson R, Lagnado A, Maggiorani D,
Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik
M, Jurk D, et al: Length-independent telomere damage drives
post-mitotic cardiomyocyte senescence. EMBO J.
38(e100492)2019.PubMed/NCBI View Article : Google Scholar
|
|
124
|
Dookun E, Walaszczyk A, Redgrave R,
Palmowski P, Tual-Chalot S, Suwana A, Chapman J, Jirkovsky E,
Donastorg Sosa L, Gill E, et al: Clearance of senescent cells
during cardiac ischemia-reperfusion injury improves recovery. Aging
Cell. 19(e13249)2020.PubMed/NCBI View Article : Google Scholar
|
|
125
|
González-Gualda E, Pàez-Ribes M,
Lozano-Torres B, Macias D, Wilson JR III, González-López C, Ou HL,
Mirón-Barroso S, Zhang Z, Lérida-Viso A, et al: Galacto-conjugation
of navitoclax as an efficient strategy to increase senolytic
specificity and reduce platelet toxicity. Aging Cell.
19(e13142)2020.PubMed/NCBI View Article : Google Scholar
|
|
126
|
Lee JR, Park BW, Park JH, Lim S, Kwon SP,
Hwang JW, Kim H, Park HJ and Kim BS: Local delivery of a senolytic
drug in ischemia and reperfusion-injured heart attenuates cardiac
remodeling and restores impaired cardiac function. Acta Biomater.
135:520–533. 2021.PubMed/NCBI View Article : Google Scholar
|
|
127
|
Nummi A, Mulari S, Stewart JA, Kivistö S,
Teittinen K, Nieminen T, Lampinen M, Pätilä T, Sintonen H, Juvonen
T, et al: Epicardial transplantation of autologous cardiac
micrografts during coronary artery bypass surgery. Front Cardiovasc
Med. 8(726889)2021.PubMed/NCBI View Article : Google Scholar
|
|
128
|
Riaud M, Martinez MC and Montero-Menei CN:
Scaffolds and extracellular vesicles as a promising approach for
cardiac regeneration after myocardial infarction. Pharmaceutics.
12(1195)2020.PubMed/NCBI View Article : Google Scholar
|
|
129
|
Koulaouzidis G, Charisopoulou D, Bomba P,
Stachura J, Gasior P, Harpula J, Zarifis J, Marlicz W, Hudziak D
and Jadczyk T: Robotic-assisted solutions for invasive cardiology,
cardiac surgery and routine on-ward tasks: A narrative review. J
Cardiovasc Dev Dis. 10(399)2023.PubMed/NCBI View Article : Google Scholar
|
|
130
|
Kędziora A, Konstanty-Kalandyk J,
Litwinowicz R, Mazur P, Kapelak B and Piątek J: Hybrid techniques
for myocardial regeneration: State of the art and future
perspectives. Adv Interv Cardiol. 18:360–365. 2022.PubMed/NCBI View Article : Google Scholar
|
|
131
|
Miller CL, Kocher M, Koweek LH and
Zwischenberger BA: Use of computed tomography for preoperative
planning in patients undergoing coronary artery bypass grafting. J
Card Surg. 37:4150–4157. 2022.PubMed/NCBI View Article : Google Scholar
|
|
132
|
Xu D, Zhang J, Liu B, Fu D, Li J and Fan
L: Determination of viable myocardium through delayed enhancement
cardiac magnetic resonance imaging combined with 18F-FDG PET
myocardial perfusion/metabolic imaging before CABG. Int J
Cardiovasc Imaging. 40:887–895. 2024.PubMed/NCBI View Article : Google Scholar
|
|
133
|
Chandrashekhara SH, Gulati GS, Sharma S,
Kumar S, Chaudhary SK, Jagia P, Seth S, Gupta SK and Khan M: Role
of cardiac MRI including LGE, T1 and T2 mapping in the assessment
of cardiac involvement in patients with nonspecific
aorto-arteritis: A prospective study. Indian J Radiol Imaging.
32:441–450. 2022.PubMed/NCBI View Article : Google Scholar
|
|
134
|
Dimitroglou Y, Karanasos A, Katsaros A,
Kalompatsou A, Tsigkas G, Toutouzas K, Tsioufis C, Aggeli C and
Davlouros P: Intraoperative transesophageal echocardiographic
guidance in cardiac surgery. J Cardiovasc Dev Dis.
12(93)2025.PubMed/NCBI View Article : Google Scholar
|
|
135
|
Fritz AV, Martin AK, Belli E and Clendenen
SR: Intraoperative epicardial ultra-high-frequency ultrasound in
coronary artery bypass grafting surgery. Cureus.
14(e22649)2022.PubMed/NCBI View Article : Google Scholar
|
|
136
|
Siimes S, Järveläinen N, Korpela H and
Ylä-Herttuala S: Endocardial gene delivery using NOGA catheter
system. Methods Mol Biol. 2573:179–187. 2022.PubMed/NCBI View Article : Google Scholar
|
|
137
|
Mashalchi S, Pahlavan S and Hejazi M: A
novel fluorescent cardiac imaging system for preclinical
intraoperative angiography. BMC Med Imaging. 21(37)2021.PubMed/NCBI View Article : Google Scholar
|
|
138
|
Ellenbroek DFJ, van Kessel L, Compagner W,
Brouwer T, Bouwman RA, van Straten BAHM, Otterspoor LC and de Bie
AJR: Diagnostic performance of echocardiography to predict cardiac
tamponade after cardiac surgery. Eur J Cardiothorac Surg.
62(ezab468)2022.PubMed/NCBI View Article : Google Scholar
|
|
139
|
Puis L, Milojevic M, Boer C, De Somer
FMJJ, Gudbjartsson T, van den Goor J, Jones TJ, Lomivorotov V,
Merkle F, Ranucci M, et al: 2019 EACTS/EACTA/EBCP guidelines on
cardiopulmonary bypass in adult cardiac surgery. Interact
Cardiovasc Thorac Surg. 30:161–202. 2019.PubMed/NCBI View Article : Google Scholar
|
|
140
|
Barbato R, Ferraresi B, Chello M, Strumia
A, Gagliardi I, Loreni F, Mattei A, Santarpino G, Carassiti M,
Grigioni F and Lusini M: Length and type of antibiotic prophylaxis
for infection prevention in adult patients in the cardiac surgery
intensive care unit: A narrative review. Antibiotics (Basel).
14(934)2025.PubMed/NCBI View Article : Google Scholar
|
|
141
|
Demkes EJ, Rijken S, Szymanski MK, Hoefer
IE, Sluijter JPG and de Jager SCA: Requirements for proper
immunosuppressive regimens to limit translational failure of
cardiac cell therapy in preclinical large animal models. J
Cardiovasc Transl Res. 14:88–99. 2021.PubMed/NCBI View Article : Google Scholar
|
|
142
|
Martin A, Weizman O, Sellal J,
Algalarrondo V, Amara W, Bouzeman A, Gandjbakhch E, Lellouche N,
Louembe J, Menet A, et al: Impact of peri-procedural management of
direct oral anticoagulants on pocket haematoma after cardiac
electronic device implantation: The StimAOD multicentre prospective
study. Europace. 25(euad057)2023.PubMed/NCBI View Article : Google Scholar
|
|
143
|
Pandozi C, Matteucci A, Pignalberi C,
Sgarra L, Bonanni M, Mariani MV, La Fazia VM, Nesti L, Di Fusco SA,
Nardi F and Colivicchi F: Antibiotic prophylaxis and treatment for
cardiac device infections. Antibiotics (Basel).
13(991)2024.PubMed/NCBI View Article : Google Scholar
|
|
144
|
Pidoux J, Conus E, Blackman N, Orrit J,
Khatchatourov G, Ruchat P, Puricel S, Cook S and Goy JJ: Comparison
of postoperative continuous wireless cardiac rhythm monitoring with
traditional telemetry in cardiac surgery patients: The SMART-TEL
study. J Innov Card Rhythm Manag. 15:5997–6003. 2024.PubMed/NCBI View Article : Google Scholar
|
|
145
|
Kawamura T, Ito Y, Ito E, Takeda M, Mikami
T, Taguchi T, Mochizuki-Oda N, Sasai M, Shimamoto T, Nitta Y, et
al: Safety confirmation of induced pluripotent stem cell-derived
cardiomyocyte patch transplantation for ischemic cardiomyopathy:
First three case reports. Front Cardiovasc Med.
10(1182209)2023.PubMed/NCBI View Article : Google Scholar
|
|
146
|
Stef A, Bodolea C, Bocsan IC, Cainap SS,
Achim A, Serban A, Solomonean AG, Tintiuc N and Buzoianu AD: The
value of biomarkers in major cardiovascular surgery necessitating
cardiopulmonary bypass. Rev Cardiovasc Med. 25(355)2024.PubMed/NCBI View Article : Google Scholar
|
|
147
|
Lee H, Cho HJ, Han Y and Lee SH: Mid- to
long-term efficacy and safety of stem cell therapy for acute
myocardial infarction: A systematic review and meta-analysis. Stem
Cell Res Ther. 15(290)2024.PubMed/NCBI View Article : Google Scholar
|
|
148
|
Fernández-Avilés F, Sanz-Ruiz R, Bogaert
J, Casado Plasencia A, Gilaberte I, Belmans A, Fernández-Santos ME,
Charron D, Mulet M, Yotti R, et al: Safety and efficacy of
intracoronary infusion of allogeneic human cardiac stem cells in
patients with ST-segment elevation myocardial infarction and left
ventricular dysfunction. Circ Res. 123:579–589. 2018.PubMed/NCBI View Article : Google Scholar
|
|
149
|
Lalu MM, Mazzarello S, Zlepnig J, Dong
YYR, Montroy J, McIntyre L, Devereaux PJ, Stewart DJ, David Mazer
C, Barron CC, et al: Safety and efficacy of adult stem cell therapy
for acute myocardial infarction and ischemic heart failure
(SafeCell Heart): A systematic review and meta-analysis. Stem Cells
Transl Med. 7:857–866. 2018.PubMed/NCBI View Article : Google Scholar
|
|
150
|
Moeswir D, Nurbaeti P, Hendarto H and
Abdul Rahman MF: Safety and efficacy of stem cell therapy in acute
myocardial infarction: A systematic review and meta-analysis of
adverse events, infarct size and left ventricular ejection fraction
assessed by CMR. Open Heart. 12(e003301)2025.PubMed/NCBI View Article : Google Scholar
|
|
151
|
Volarevic V, Markovic BS, Gazdic M,
Volarevic A, Jovicic N, Arsenijevic N, Armstrong L, Djonov V, Lako
M and Stojkovic M: Ethical and safety issues of stem cell-based
therapy. Int J Med Sci. 15:36–45. 2018.PubMed/NCBI View Article : Google Scholar
|
|
152
|
Chen K, Huang Y, Singh R and Wang ZZ:
Arrhythmogenic risks of stem cell replacement therapy for
cardiovascular diseases. J Cell Physiol. 235:6257–6267.
2020.PubMed/NCBI View Article : Google Scholar
|
|
153
|
Niemansburg SL, Teraa M, Hesam H, van
Delden JJ, Verhaar MC and Bredenoord AL: Stem cell trials for
cardiovascular medicine: Ethical rationale. Tissue Eng Part A.
20:2567–2574. 2014.PubMed/NCBI View Article : Google Scholar
|
|
154
|
Jayaram P, Danilkowicz RM and Yuan X:
Ethical and regulatory considerations related to regenerative
medicine. HSS J. 21:463–468. 2025.PubMed/NCBI View Article : Google Scholar
|
|
155
|
Lindeman A, Pepine CJ and March KL:
Cardiac stem cell therapy among Clinics of Uncertain Regulatory
Status (COURS): Under-regulated, under-observed, incompletely
understood. J Transl Med. 18(285)2020.PubMed/NCBI View Article : Google Scholar
|
|
156
|
Fujita M, Policastro GM, Burdick A, Lam
HT, Ungerleider JL, Braden RL, Huang D, Osborn KG, Omens JH, Madani
MM and Christman KL: Preventing post-surgical cardiac adhesions
with a catechol-functionalized oxime hydrogel. Nat Commun.
12(3764)2021.PubMed/NCBI View Article : Google Scholar
|
|
157
|
Razavi ZS, Farokhi S, Mahmoudvand G,
Karimi-Rouzbahani A, Farasati-Far B, Tahmasebi-Ghorabi S,
Pazoki-Toroudi H, Saadat-Fakhr M and Afkhami H: Stem cells and bio
scaffolds for the treatment of cardiovascular diseases: New
insights. Front Cell Dev Biol. 12(1472103)2024.PubMed/NCBI View Article : Google Scholar
|
|
158
|
Food and Drug Administration. Regenerative
Medicine Advanced Therapy (RMAT) Designation. FDA. Published July
18, 2025. Available from: https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/regenerative-medicine-advanced-therapy-designation.
Accessed December 14, 2025.
|
|
159
|
Food and Drug Administration. Expedited
Programs for Regenerative Medicine Therapies for Serious
Conditions: Guidance for Industry. FDA. Published February, 2019.
Available from: https://www.fda.gov/media/120267/download. Accessed
December 14, 2025.
|
|
160
|
European Medicines Agency. Advanced
Therapy Medicinal Products (ATMPs)-Overview. EMA. Published 2024.
Available from: https://www.ema.europa.eu/en/human-regulatory-overview/advanced-therapy-medicinal-products-overview.
Accessed December 14, 2025.
|
|
161
|
European Commission/European
Parliament/Council. Regulation (EC) No 1394/2007 on Advanced
Therapy Medicinal Products. EUR-Lex. Published November 13, 2007.
Available from: https://eur-lex.europa.eu/eli/reg/2007/1394/oj/eng.
Accessed December 14, 2025.
|
|
162
|
Liew LC, Ho BX and Soh B: Mending a broken
heart: Current strategies and limitations of cell-based therapy.
Stem Cell Res Ther. 11(138)2020.PubMed/NCBI View Article : Google Scholar
|
|
163
|
Guo M, Watanabe T and Shinoka T:
Injectable stem cell-based therapies for myocardial regeneration: A
review of the literature. J Funct Biomater. 16(152)2025.PubMed/NCBI View Article : Google Scholar
|
|
164
|
Vasu S, Zhou J, Chen J, Johnston PV and
Kim D: Biomaterials-based approaches for cardiac regeneration.
Korean Circ J. 51(943)2021.PubMed/NCBI View Article : Google Scholar
|
|
165
|
Bois A, Grandela C, Gallant J, Mummery C
and Menasché P: Revitalizing the heart: Strategies and tools for
cardiomyocyte regeneration post-myocardial infarction. NPJ Regen
Med. 10(6)2025.PubMed/NCBI View Article : Google Scholar
|
|
166
|
Wang J, An M, Haubner BJ and Penninger JM:
Cardiac regeneration: Options for repairing the injured heart.
Front Cardiovasc Med. 9(981982)2023.PubMed/NCBI View Article : Google Scholar
|
|
167
|
Soczyńska J, Gawełczyk W, Majcherczyk K,
Rydzek J, Muzyka A, Żołyniak M and Woźniak S: Cells versus
cell-derived signals in cardiac regenerative therapy: A comparative
analysis of mechanisms and clinical evidence. Cells.
14(1674)2025.PubMed/NCBI View Article : Google Scholar
|
|
168
|
Chingale M, Zhu D, Cheng K and Huang K:
Bioengineering technologies for cardiac regenerative medicine.
Front Bioeng Biotechnol. 9(681705)2021.PubMed/NCBI View Article : Google Scholar
|
|
169
|
Benz DC, Gräni C, Antiochos P, Heydari B,
Gissler MC, Ge Y, Cuddy SAM, Dorbala S and Kwong RY: Cardiac
magnetic resonance biomarkers as surrogate endpoints in
cardiovascular trials for myocardial diseases. Eur Heart J.
44:4738–4747. 2023.PubMed/NCBI View Article : Google Scholar
|
|
170
|
Wulfse M, Vervoorn MT, Amelink JJGJ,
Ballan EM, De Jager SCA, Sluijter JPG, Doevendans PA, Zwetsloot PM
and Van der Kaaij NP: Past trends and future directions of cardiac
regenerative medicine: A systematic analysis of clinical trial
registries. J Cardiovasc Transl Res. 18:209–220. 2024.PubMed/NCBI View Article : Google Scholar
|
|
171
|
Bolli R and Tang X: Clinical trials of
cell therapy for heart failure: Recent results warrant continued
research. Curr Opin Cardiol. 37:193–200. 2022.PubMed/NCBI View Article : Google Scholar
|
|
172
|
de Carvalho ACC, Kasai-Brunswick TH and
Carvalho AB: Cell-based therapies for heart failure. Front
Pharmacol. 12(641116)2021.PubMed/NCBI View Article : Google Scholar
|
|
173
|
Beetler DJ, Di Florio DN, Law EW, Groen
CM, Windebank AJ, Peterson QP and Fairweather D: The evolving
regulatory landscape in regenerative medicine. Mol Aspects Med.
91(101138)2022.PubMed/NCBI View Article : Google Scholar
|
|
174
|
Leikas AJ, Hartikainen JEK, Kastrup J,
Mathur A, Gyöngyösi M, Fernández-Avilés F, Sanz-Ruiz R, Wojakowski
W, Gwizdała A, Luite R, et al: Clinical development and
proof-of-principle testing of new regenerative vascular endothelial
growth factor-D therapy for refractory angina: Rationale and design
of the phase 2 ReGenHeart trial. Open Heart.
11(e002817)2024.PubMed/NCBI View Article : Google Scholar
|
|
175
|
Amoiradaki K, Tomczyk M, Wang X, Cruz G,
Velasco C, Zentilin L, Bortolotti F, Prieto C, Botnar RM, Giacca M
and Phinikaridou A: Molecular and functional MRI enables detection
of cardiac fibrosis and evaluation of treatment response after
chordin-like 1 gene therapy in myocardial infarction. Theranostics.
15:8706–8718. 2025.PubMed/NCBI View Article : Google Scholar
|
|
176
|
Miyagawa S, Kawamura T, Ito E, Takeda M,
Iseoka H, Yokoyama J, Harada A, Mochizuki-Oda N, Imanishi-Ochi Y,
Li J, et al: Pre-clinical evaluation of the efficacy and safety of
human induced pluripotent stem cell-derived cardiomyocyte patch.
Stem Cell Res Ther. 15(73)2024.PubMed/NCBI View Article : Google Scholar
|
|
177
|
Pepine CJ and Raval AN: The CardiAMP cell
therapy for heart failure trial. Tex Heart Inst J.
50(e238242)2023.PubMed/NCBI View Article : Google Scholar
|
|
178
|
Hare JM, DiFede DL, Rieger AC, Florea V,
Landin AM, El-Khorazaty J, Khan A, Mushtaq M, Lowery MH, Byrnes JJ,
et al: Randomized comparison of allogeneic versus autologous
mesenchymal stem cells for nonischemic dilated cardiomyopathy:
POSEIDON-DCM Trial. J Am Coll Cardiol. 69:526–537. 2017.PubMed/NCBI View Article : Google Scholar
|
|
179
|
Khan MS, Smego D, Li J, Ishidoya Y, Offei
E, Ruiz Castillo MS, Hirahara AM, Balmaceda P, Hunter J, Athavale
A, et al: AAV9-cBIN1 gene therapy rescues chronic heart failure due
to ischemic cardiomyopathy in a canine model. Commun Med (Lond).
5(93)2025.PubMed/NCBI View Article : Google Scholar
|
|
180
|
Aggarwal R, Shao A, Potel KN, So SW,
Swingen CM, Wright CA, Hocum Stone LL, McFalls EO, Butterick TA and
Kelly RF: Stem cell-derived exosome patch with coronary artery
bypass graft restores cardiac function in chronically ischemic
porcine myocardium. J Thorac Cardiovasc Surg. 166:e512–e530.
2023.PubMed/NCBI View Article : Google Scholar
|
|
181
|
Aggarwal R, Potel KN, Shao A, So SW,
Swingen C, Reyes CP, Rose R, Wright C, Hocum Stone LL, McFalls EO,
et al: An adjuvant stem cell patch with coronary artery bypass
graft surgery improves diastolic recovery in porcine hibernating
myocardium. Int J Mol Sci. 24(5475)2023.PubMed/NCBI View Article : Google Scholar
|
|
182
|
Liu Z, Zheng Z, Xie J, Wei H and Yu C:
Hydrogel-based cardiac patches for myocardial infarction therapy:
Recent advances and challenges. Mater Today Bio.
29(101331)2024.PubMed/NCBI View Article : Google Scholar
|
|
183
|
Jiménez-Jara C, Salas R, Díaz-Navarro R,
Chabert S, Andia ME, Vega J, Urbina J, Uribe S, Sekine T, Raimondi
F and Sotelo J: AI applied to cardiac magnetic resonance for
precision medicine in coronary artery disease: A systematic review.
J Cardiovasc Dev Dis. 12(345)2025.PubMed/NCBI View Article : Google Scholar
|
|
184
|
Petch J, Bortesi JPT, Sheth T, Natarajan
M, Pinilla-Echeverri N, Di S, Bangdiwala SI, Mosleh K, Ibrahim O,
Bainey KR, et al: Coronary computed tomographic angiography to
optimize the diagnostic yield of invasive angiography for low-risk
patients screened with artificial intelligence: Protocol for the
CarDIA-AI randomized controlled trial. JMIR Res Protoc.
14(e71726)2025.PubMed/NCBI View
Article : Google Scholar
|
|
185
|
Batho CA, Hudson JE and Wilson CH: Using
modified mRNA for cardiomyocyte proliferation and cardiac genetic
disease modelling and treatment. Biochem Soc Trans. 53:1151–1168.
2025.PubMed/NCBI View Article : Google Scholar
|
|
186
|
Cheng Y, Hu Y and Hsieh PC: The role of
large animal models in cardiac regeneration research using human
pluripotent stem cell-derived cardiomyocytes. Curr Cardiol Rep.
25:325–331. 2023.PubMed/NCBI View Article : Google Scholar
|
|
187
|
Watanabe T, Hatayama N, Guo M, Yuhara S
and Shinoka T: Bridging the gap: Advances and challenges in heart
regeneration from in vitro to in vivo applications. Bioengineering.
11(954)2024.PubMed/NCBI View Article : Google Scholar
|
|
188
|
Wysoczynski M and Bolli R: A realistic
appraisal of the use of embryonic stem cell-based therapies for
cardiac repair. Eur Heart J. 41:2397–2404. 2019.PubMed/NCBI View Article : Google Scholar
|
|
189
|
Youssef AA, Ross EG, Bolli R, Pepine CJ,
Leeper NJ and Yang PC: The promise and challenge of induced
pluripotent stem cells for cardiovascular applications. JACC Basic
Transl Sci. 1:510–523. 2016.PubMed/NCBI View Article : Google Scholar
|
|
190
|
Sugiura T, Nawaz S, Shahannaz DC, Ferrell
BE and Yoshida T: From injury to repair: The therapeutic potential
of induced pluripotent stem cells in heart failure. Regen Med Rep.
2:22–30. 2025.
|
|
191
|
Harris AR, Walker MJ and Gilbert F:
Ethical and regulatory issues of stem cell-derived 3-dimensional
organoid and tissue therapy for personalised regenerative medicine.
BMC Med. 20(499)2022.PubMed/NCBI View Article : Google Scholar
|
|
192
|
Farboud SP, Fathi E, Valipour B and
Farahzadi R: Toward the latest advancements in cardiac regeneration
using induced pluripotent stem cells (iPSCs) technology: Approaches
and challenges. J Transl Med. 22(783)2024.PubMed/NCBI View Article : Google Scholar
|
|
193
|
Edpuganti S, Subhash S, Subrahmaniyan SL,
Latheef S and Albarari SS: Gut microbiome and cardiovascular
health: Mechanisms, therapeutic potential and future directions.
Heart Int. 19:12–20. 2025.PubMed/NCBI View Article : Google Scholar
|
|
194
|
Edpuganti S, Shamim A, Gangolli VH,
Weerasekara RADKN and Yellamilli A: Artificial intelligence in
cardiovascular imaging: Current landscape, clinical impact, and
future directions. Discov (Craiova). 13(e211)2025.PubMed/NCBI View Article : Google Scholar
|
