Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Medicine International
Join Editorial Board Propose a Special Issue
Print ISSN: 2754-3242 Online ISSN: 2754-1304
Journal Cover
September-October 2026 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-October 2026 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Primary hyperparathyroidism associated with genu valgum in a young girl: Report of a rare case

  • Authors:
    • Bayar A. Qasim
    • Laween O. Musa
    • Ayoob M.T. Abdulrahman
    • Sohaib H. Ali
    • Halder J. Abozait
    • Abdulkareem M. Jomaa
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, College of Medicine, University of Duhok, Duhok, Kurdistan Region 42001, Iraq, Department of Surgery, College of Medicine, University of Duhok, Duhok, Kurdistan Region 42001, Iraq, Heevi Paediatric Teaching Hospital, Duhok, Kurdistan Region 42001, Iraq, Department of Biomedical Sciences, College of Medicine, University of Zakho, Zakho Independent Administration, Kurdistan Region 42002, Iraq
    Copyright: © Qasim et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 48
    |
    Published online on: July 27, 2026
       https://doi.org/10.3892/mi.2026.332
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

Primary hyperparathyroidism (PHPT) is rare in children and may present with skeletal deformities. The present case report describes the case of a 12‑year‑old girl with progressive bilateral genu valgum and bone pain unresponsive to corrective osteotomy and supplementation. She had a prior episode of hypercalcemia during acute pancreatitis. Laboratory analyses revealed elevated calcium levels (12.2 mg/dl), markedly high levels of parathyroid hormone (PTH; 1,574 pg/ml), low vitamin D levels (13.3 ng/ml) and increased levels of alkaline phosphatase (2616 U/l). A neck ultrasonography revealed a right parathyroid adenoma, and radiographs revealed multiple expansile, cystic lesions with a ‘soap‑bubble’ appearance. A histopathological analysis confirmed osteitis fibrosa cystica (brown tumor). Radiofrequency ablation of the adenoma normalized the calcium and PTH levels, with the near‑complete radiological resolution of lesions and the marked clinical improvement of genu valgum. The present case report highlights a rare pediatric presentation of PHPT with osteitis fibrosa cystica and genu valgum, initially misdiagnosed as an orthopedic disorder. Early endocrine evaluation in children with unexplained bone deformities is essential to prevent unnecessary surgical interventions and morbidity. Successful management of the parathyroid lesion led to substantial, although not formally quantified, clinical and radiological improvement.
View Figures

Figure 1

Ultrasound of the parathyroid glands
demonstrating a well-defined vascular hypoechoic lesion of 13x26 mm
in size located in the right infrathyroid area suggestive of a
parathyroid adenoma.

Figure 2

X-ray images of the lower limbs. (A
and B) Anteroposterior view and (C and D) lateral view images. (A)
Anteroposterior view illustrating a well-defined, expansile lesion
in the proximal part of left tibia. The lesion exhibited a
‘soap-bubble’ appearance with cortical thinning and disruption of
continuity, but no periosteal reaction. Another well-defined cystic
lesion is shown in the proximal right tibia (red arrows). Overall
bone density appears diminished. There is a plate and screw in the
medial side of distal left femur. (C) Lateral view illustrating the
lesion in the proximal area of the left tibia. (B) Anteroposterior
view and (D) lateral view images following treatment demonstrating
the almost-complete resolution of the lesions with significant
mineralization compared to before treatment.
View References

1 

Walker MD and Silverberg SJ: Primary hyperparathyroidism. Nat Rev Endocrinol. 14:115–125. 2018.PubMed/NCBI View Article : Google Scholar

2 

Marcocci C and Cetani F: Clinical practice. Primary hyperparathyroidism. N Engl J Med. 365:2389–2397. 2011.PubMed/NCBI View Article : Google Scholar

3 

Yeh MW, Ituarte PH, Zhou HC, Nishimoto S, Liu IL, Harari A, Haigh PI and Adams AL: Incidence and prevalence of primary hyperparathyroidism in a racially mixed population. J Clin Endocrinol Metab. 98:1122–1129. 2013.PubMed/NCBI View Article : Google Scholar

4 

Bandeira F, Griz L, Caldas G, Bandeira C and Freese E: From mild to severe primary hyperparathyroidism: The Brazilian experience. Arq Bras Endocrinol Metabol. 50:657–663. 2006.PubMed/NCBI View Article : Google Scholar

5 

Panagopoulos A, Tatani I, Kourea HP, Kokkalis ZT, Panagopoulos K and Megas P: Osteolytic lesions (brown tumors) of primary hyperparathyroidism misdiagnosed as multifocal giant cell tumor of the distal ulna and radius: A case report. J Med Case Rep. 12(176)2018.PubMed/NCBI View Article : Google Scholar

6 

Issa PP, Kandil E and Lee GS: Radiofrequency ablation as a treatment modality for primary hyperparathyroidism: A systematic literature review. Gland Surg. 13:87–99. 2024.PubMed/NCBI View Article : Google Scholar

7 

Sakale H, Garg AK, Bhardwaj S and Agrawal AC: Genu valgum in children with primary hyperparathyroidism: A case series with a review of the literature. J Family Med Prim Care. 13:5912–5916. 2024.PubMed/NCBI View Article : Google Scholar

8 

De Crea C, Traini E, Oragano L, Bellantone C, Raffaelli M and Lombardi CP: Are brown tumours a forgotten disease in developed countries? Acta Otorhinolaryngol Ital. 32:410–415. 2012.PubMed/NCBI

9 

Vanitcharoenkul E, Singsampun N, Unnanuntana A and Sirinvaravong S: Osteitis Fibrosa Cystica and pathological fractures-the classic but neglected skeletal manifestation of primary hyperparathyroidism: A case report. BMC Musculoskeletal Disorders. 22(443)2021.PubMed/NCBI View Article : Google Scholar

10 

Qasim BA: Historical landmarks in endocrinology and diabetes: The fascinating world of hormones. Newcastle upon Tyne: Cambridge Scholars Publishing, 2024.

11 

Hamrah Siyani M, Zandiyeh F, Zaremoghadam E, Dehghan S, Sadeghian R, Aboulfathiyarmohammadyar Z and Alipoor M: Association of parathyroid hormone with plasma magnesium in health and disease; a review. J Parathyr Dis. 11(e11211)2023.

12 

Bilezikian JP, Khan AA, Clarke BL, Mannstadt M, Potts JT and Brandi ML: The fifth international workshop on the evaluation and management of primary hyperparathyroidism. J Bone Miner Res. 37:2290–2292. 2020.PubMed/NCBI View Article : Google Scholar

13 

de Silva NL, Jayalath MD, Sampath WKC, Perera R and Karunathilake C: Primary hyperparathyroidism in an adolescent presenting with genu valgus progressing to extensive bone disease; a case report. BMC Endocr Disord. 23(71)2023.PubMed/NCBI View Article : Google Scholar

14 

Boro H, Khatiwada S, Alam S, Kubihal S, Dogra V, Malla S and Kumar C: The spectrum of manifestations of primary hyperparathyroidism in children and adolescents. Pediatr Endocrinol Diabetes Metab. 28:178–187. 2022.PubMed/NCBI View Article : Google Scholar

15 

Starker LF, Akerström T, Long WD, Delgado-Verdugo A, Donovan P, Udelsman R, Lifton RP and Carling T: Frequent germ-line mutations of the MEN1, CASR, and HRPT2/CDC73 genes in young patients with clinically non-familial primary hyperparathyroidism. Horm Cancer. 3:44–51. 2011.PubMed/NCBI View Article : Google Scholar

16 

Yedla N, Kim H, Sharma A and Wang X: Vitamin D deficiency and the presentation of primary hyperparathyroidism: A mini review. Int J Endocrinol. 2023(1169249)2023.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
Copy and paste a formatted citation
Spandidos Publications style
Qasim BA, Musa LO, Abdulrahman AM, Ali SH, Abozait HJ and Jomaa AM: Primary hyperparathyroidism associated with genu valgum in a young girl: Report of a rare case. Med Int 6: 48, 2026.
APA
Qasim, B.A., Musa, L.O., Abdulrahman, A.M., Ali, S.H., Abozait, H.J., & Jomaa, A.M. (2026). Primary hyperparathyroidism associated with genu valgum in a young girl: Report of a rare case. Medicine International, 6, 48. https://doi.org/10.3892/mi.2026.332
MLA
Qasim, B. A., Musa, L. O., Abdulrahman, A. M., Ali, S. H., Abozait, H. J., Jomaa, A. M."Primary hyperparathyroidism associated with genu valgum in a young girl: Report of a rare case". Medicine International 6.5 (2026): 48.
Chicago
Qasim, B. A., Musa, L. O., Abdulrahman, A. M., Ali, S. H., Abozait, H. J., Jomaa, A. M."Primary hyperparathyroidism associated with genu valgum in a young girl: Report of a rare case". Medicine International 6, no. 5 (2026): 48. https://doi.org/10.3892/mi.2026.332
Copy and paste a formatted citation
x
Spandidos Publications style
Qasim BA, Musa LO, Abdulrahman AM, Ali SH, Abozait HJ and Jomaa AM: Primary hyperparathyroidism associated with genu valgum in a young girl: Report of a rare case. Med Int 6: 48, 2026.
APA
Qasim, B.A., Musa, L.O., Abdulrahman, A.M., Ali, S.H., Abozait, H.J., & Jomaa, A.M. (2026). Primary hyperparathyroidism associated with genu valgum in a young girl: Report of a rare case. Medicine International, 6, 48. https://doi.org/10.3892/mi.2026.332
MLA
Qasim, B. A., Musa, L. O., Abdulrahman, A. M., Ali, S. H., Abozait, H. J., Jomaa, A. M."Primary hyperparathyroidism associated with genu valgum in a young girl: Report of a rare case". Medicine International 6.5 (2026): 48.
Chicago
Qasim, B. A., Musa, L. O., Abdulrahman, A. M., Ali, S. H., Abozait, H. J., Jomaa, A. M."Primary hyperparathyroidism associated with genu valgum in a young girl: Report of a rare case". Medicine International 6, no. 5 (2026): 48. https://doi.org/10.3892/mi.2026.332
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team