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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2008 Volume 1 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Relationship between peroxisome proliferator-activated receptor-γ and renal ischemia-reperfusion injury

  • Authors:
    • Masahide Matsuyama
    • Rikio Yoshimura
    • Yutaka Kawahito
    • Hajime Sano
    • Jamel Chargui
    • Jean-Louis Touraine
    • Tatsuya Nakatani

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
  • Pages: 499-503
    |
    Published online on: July 1, 2008
       https://doi.org/10.3892/mmr.1.4.499
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Abstract

The pathogenesis of ischemia-reperfusion (I/R) injury is known to involve cytokines and, in particular, surface adhesion molecules, the expression of which initiates inflammatory cell attachment. It has been suggested that peroxisome proliferator-activated receptor (PPAR)-γ is an important immunomodulatory factor as well as a regulator of fatty acid. In this study, we investigated the expression of PPAR-γ in a renal I/R injury rat model. The right kidney was harvested and the left renal artery and vein were clamped by means of a laparotomy. The kidney was reperfused following 90 min of ischemia. Rats were sacrificed at 0, 1.5, 3, 5, 12 and 24 h after reperfusion. PPAR-γ expression was analyzed by immunohistochemical staining using monoclonal antibody. PPAR-γ staining was weak in the endothelial cells, interstitial cells and collecting ducts in the normal kidney. From 1.5 to 5 h after reperfusion, PPAR-γ staining was strong. Twelve hours after reperfusion, necrosis had extended throughout the kidney, and nearly all the tubular epithelial cells were destroyed. However, 12 h after reperfusion, PPAR-γ staining was weak in the endothelial cells and its expression was moderate in the interstitial cells and collecting ducts. PPAR-γ was induced in the endothelial cells, including the mesangial cells, interstitial cells and collecting ducts in a rat model of renal I/R injury.

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Copy and paste a formatted citation
Spandidos Publications style
Matsuyama M, Yoshimura R, Kawahito Y, Sano H, Chargui J, Touraine J and Nakatani T: Relationship between peroxisome proliferator-activated receptor-γ and renal ischemia-reperfusion injury. Mol Med Rep 1: 499-503, 2008.
APA
Matsuyama, M., Yoshimura, R., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., & Nakatani, T. (2008). Relationship between peroxisome proliferator-activated receptor-γ and renal ischemia-reperfusion injury. Molecular Medicine Reports, 1, 499-503. https://doi.org/10.3892/mmr.1.4.499
MLA
Matsuyama, M., Yoshimura, R., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., Nakatani, T."Relationship between peroxisome proliferator-activated receptor-γ and renal ischemia-reperfusion injury". Molecular Medicine Reports 1.4 (2008): 499-503.
Chicago
Matsuyama, M., Yoshimura, R., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., Nakatani, T."Relationship between peroxisome proliferator-activated receptor-γ and renal ischemia-reperfusion injury". Molecular Medicine Reports 1, no. 4 (2008): 499-503. https://doi.org/10.3892/mmr.1.4.499
Copy and paste a formatted citation
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Spandidos Publications style
Matsuyama M, Yoshimura R, Kawahito Y, Sano H, Chargui J, Touraine J and Nakatani T: Relationship between peroxisome proliferator-activated receptor-γ and renal ischemia-reperfusion injury. Mol Med Rep 1: 499-503, 2008.
APA
Matsuyama, M., Yoshimura, R., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., & Nakatani, T. (2008). Relationship between peroxisome proliferator-activated receptor-γ and renal ischemia-reperfusion injury. Molecular Medicine Reports, 1, 499-503. https://doi.org/10.3892/mmr.1.4.499
MLA
Matsuyama, M., Yoshimura, R., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., Nakatani, T."Relationship between peroxisome proliferator-activated receptor-γ and renal ischemia-reperfusion injury". Molecular Medicine Reports 1.4 (2008): 499-503.
Chicago
Matsuyama, M., Yoshimura, R., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., Nakatani, T."Relationship between peroxisome proliferator-activated receptor-γ and renal ischemia-reperfusion injury". Molecular Medicine Reports 1, no. 4 (2008): 499-503. https://doi.org/10.3892/mmr.1.4.499
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