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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2008 Volume 1 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Expression of cytokeratin 19 in the cytosolic fraction of thyroid lesions: ELISA and Western blot analysis

  • Authors:
    • Anna Krzeslak
    • Zuzanna Gaj
    • Lech Pomorski
    • Anna Lipinska

  • View Affiliations / Copyright

    Affiliations: Department of Cytobiochemistry, University of Lódz, 90-237 Lódz, Poland
  • Pages: 565-569
    |
    Published online on: July 1, 2008
       https://doi.org/10.3892/mmr.1.4.565
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Abstract

Cytokeratin 19 (CK19) is one of the most frequently studied immunohistochemical markers in thyroid pathology. The results of several studies suggest that CK19 may be useful in the diagnosis of papillary carcinoma, where it has been shown to have strong diffuse cytoplasmic reactivity. However, the published results vary, and the utility of CK19 in the diagnosis of thyroid lesions is controversial. The aim of this study was to evaluate, by Western blot analysis and the enzyme-linked immunosorbent assay (ELISA), the expression of CK19 in the cytosolic fraction obtained from 125 specimens of various thyroid lesions: nodular goiters, follicular adenomas, papillary carcinomas, follicular carcinomas and anaplastic carcinomas. The analysis of CK19 expression using the ELISA showed that the majority of papillary carcinoma cases had a much higher level of CK19 than did nodular goiters and adenomas (P<0.001). Western blot analysis revealed the presence of CK19 in 66% of papillary carcinoma cases. CK19 expression was also found in 11, 22, 25 and 25% of nodular goiters, follicular adenomas, and follicular and anaplastic carcinomas, respectively. The results demonstrate that the evaluation of CK19 expression may be helpful in distinguishing papillary carcinoma from other benign and malignant thyroid nodules, but cannot by itself be used to establish a diagnosis.

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Copy and paste a formatted citation
Spandidos Publications style
Krzeslak A, Gaj Z, Pomorski L and Lipinska A: Expression of cytokeratin 19 in the cytosolic fraction of thyroid lesions: ELISA and Western blot analysis. Mol Med Rep 1: 565-569, 2008.
APA
Krzeslak, A., Gaj, Z., Pomorski, L., & Lipinska, A. (2008). Expression of cytokeratin 19 in the cytosolic fraction of thyroid lesions: ELISA and Western blot analysis. Molecular Medicine Reports, 1, 565-569. https://doi.org/10.3892/mmr.1.4.565
MLA
Krzeslak, A., Gaj, Z., Pomorski, L., Lipinska, A."Expression of cytokeratin 19 in the cytosolic fraction of thyroid lesions: ELISA and Western blot analysis". Molecular Medicine Reports 1.4 (2008): 565-569.
Chicago
Krzeslak, A., Gaj, Z., Pomorski, L., Lipinska, A."Expression of cytokeratin 19 in the cytosolic fraction of thyroid lesions: ELISA and Western blot analysis". Molecular Medicine Reports 1, no. 4 (2008): 565-569. https://doi.org/10.3892/mmr.1.4.565
Copy and paste a formatted citation
x
Spandidos Publications style
Krzeslak A, Gaj Z, Pomorski L and Lipinska A: Expression of cytokeratin 19 in the cytosolic fraction of thyroid lesions: ELISA and Western blot analysis. Mol Med Rep 1: 565-569, 2008.
APA
Krzeslak, A., Gaj, Z., Pomorski, L., & Lipinska, A. (2008). Expression of cytokeratin 19 in the cytosolic fraction of thyroid lesions: ELISA and Western blot analysis. Molecular Medicine Reports, 1, 565-569. https://doi.org/10.3892/mmr.1.4.565
MLA
Krzeslak, A., Gaj, Z., Pomorski, L., Lipinska, A."Expression of cytokeratin 19 in the cytosolic fraction of thyroid lesions: ELISA and Western blot analysis". Molecular Medicine Reports 1.4 (2008): 565-569.
Chicago
Krzeslak, A., Gaj, Z., Pomorski, L., Lipinska, A."Expression of cytokeratin 19 in the cytosolic fraction of thyroid lesions: ELISA and Western blot analysis". Molecular Medicine Reports 1, no. 4 (2008): 565-569. https://doi.org/10.3892/mmr.1.4.565
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