Modification of the effect of smoking on cholesterol in Japanese carriers of a PTPN11 polymorphism

Okada,Rieko; Suzuki,Koji; Nishio,Kazuko; Ishida,Yoshiko; Kawai,Sayo; Goto,Yasuyuki; Naito,Mariko; Wakai,Kenji; Ito,Yoshinori; Hamajima,Nobuyuki

doi:10.3892/mmr.1.4.595

July-August 2008 Volume 1 Issue 4

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July-August 2008 Volume 1 Issue 4

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Article

Modification of the effect of smoking on cholesterol in Japanese carriers of a PTPN11 polymorphism

Authors:
- Rieko Okada
- Koji Suzuki
- Kazuko Nishio
- Yoshiko Ishida
- Sayo Kawai
- Yasuyuki Goto
- Mariko Naito
- Kenji Wakai
- Yoshinori Ito
- Nobuyuki Hamajima
View Affiliations / Copyright

Affiliations: Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. rieokada@med.nagoya-u.ac.jp
Pages: 595-598
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Published online on: July 1, 2008

https://doi.org/10.3892/mmr.1.4.595
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Abstract

A widely-expressed protein tyrosine phosphatase, SHP-2, regulates apoB secretion by insulin. We hypothesised that a variation in the SHP-2 gene, PTPN11, may interact with smoking to influence serum lipid concentrations. The study comprised 794 subjects (278 males and 516 females), aged 39-88 years, who attended a health examination in Hokkaido, Japan in 2003. Subjects were genotyped for a G/A PTPN11 polymorphism (rs2301756). The mean serum LDL cholesterol, HDL cholesterol and triglyceride levels, stratified by genotype, were compared between current and non- (never or ex-) smokers. Among the AA genotype carriers, LDL cholesterol levels were significantly decreased in current vs. non-smokers [mean ± SD, 101±34 mg/dl vs. 146±40 mg/dl; b (adjusted mean difference) = −56.0; 95% CI −102.8 to −9.3; p=0.019 after adjustment for age, sex and body mass index]. In contrast, HDL cholesterol levels were increased in current vs. non-smokers (66±5 mg/dl vs. 58±12 mg/dl; b=14.9; 95% CI 3.1 to 26.8; p=0.014 after adjustment). The interaction between a current smoking habit and the AA genotype had a significant effect on LDL and HDL cholesterol (LDL-C, p=0.039; HDL-C, p=0.020). These data suggest that cigarette smoking might alter the metabolism of cholesterol in Japanese PTPN11 AA genotype carriers.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Modification of the effect of smoking on cholesterol in Japanese carriers of a PTPN11 polymorphism

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