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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2008 Volume 1 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-August 2008 Volume 1 Issue 4

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Article

Deregulated expression of the per2 gene in human colorectal carcinoma

  • Authors:
    • Michal Zeman
    • Marián Vician
    • Jana Monosíková
    • Richard Reis
    • Iveta Herichová
  • View Affiliations / Copyright

    Affiliations: Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University Bratislava, 842 15 Bratislava, Slovak Republic
  • Pages: 599-603
    |
    Published online on: July 1, 2008
       https://doi.org/10.3892/mmr.1.4.599
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Abstract

The circadian system is involved in the control of cell proliferation and apoptosis. The aim of this study was to analyze expression of the human per2 gene in patients who underwent surgery for colorectal carcinoma. The study included 25 patients of both genders. Patients were exposed to light from 6:00 a.m. until 9:00 p.m. according to standard hospital practice. Tissue samples were taken from the tumor as well as from the proximal and distal areas of the resected colon at the time of surgery. Surgery was performed during the morning hours. Expression of per2 mRNA was measured by real-time PCR. There was a significant negative correlation between per2 gene expression and tumor staging. Expression of per2 mRNA did not correlate with whether the tumor was localized in the colon or rectum. In comparison with ectomized tissue without malignancy from patients with colorectal carcinoma, our data demonstrate per2 mRNA deregulation in tumor tissue, and suggest a way in which the circadian system can influence tumorigenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Zeman M, Vician M, Monosíková J, Reis R and Herichová I: Deregulated expression of the per2 gene in human colorectal carcinoma. Mol Med Rep 1: 599-603, 2008.
APA
Zeman, M., Vician, M., Monosíková, J., Reis, R., & Herichová, I. (2008). Deregulated expression of the per2 gene in human colorectal carcinoma. Molecular Medicine Reports, 1, 599-603. https://doi.org/10.3892/mmr.1.4.599
MLA
Zeman, M., Vician, M., Monosíková, J., Reis, R., Herichová, I."Deregulated expression of the per2 gene in human colorectal carcinoma". Molecular Medicine Reports 1.4 (2008): 599-603.
Chicago
Zeman, M., Vician, M., Monosíková, J., Reis, R., Herichová, I."Deregulated expression of the per2 gene in human colorectal carcinoma". Molecular Medicine Reports 1, no. 4 (2008): 599-603. https://doi.org/10.3892/mmr.1.4.599
Copy and paste a formatted citation
x
Spandidos Publications style
Zeman M, Vician M, Monosíková J, Reis R and Herichová I: Deregulated expression of the per2 gene in human colorectal carcinoma. Mol Med Rep 1: 599-603, 2008.
APA
Zeman, M., Vician, M., Monosíková, J., Reis, R., & Herichová, I. (2008). Deregulated expression of the per2 gene in human colorectal carcinoma. Molecular Medicine Reports, 1, 599-603. https://doi.org/10.3892/mmr.1.4.599
MLA
Zeman, M., Vician, M., Monosíková, J., Reis, R., Herichová, I."Deregulated expression of the per2 gene in human colorectal carcinoma". Molecular Medicine Reports 1.4 (2008): 599-603.
Chicago
Zeman, M., Vician, M., Monosíková, J., Reis, R., Herichová, I."Deregulated expression of the per2 gene in human colorectal carcinoma". Molecular Medicine Reports 1, no. 4 (2008): 599-603. https://doi.org/10.3892/mmr.1.4.599
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