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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2010 Volume 3 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Actin disruption inhibits hypoxia inducible factor-1α expression via inactivity of Mdm2-mediated p70S6K

  • Authors:
    • Ik Jae Shin
    • Bae Keun Park
    • Yong-Tae Ahn
    • Yongkuk Kim
    • Won G. An

  • View Affiliations / Copyright

    Affiliations: Joint Research Center of Pusan National University-Fraunhofer IGB, Busan 609-735, Korea, Institute of Basic Medical Science, Yonsei University Wonju College of Medicine, Gangwon 220-701, Korea, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA, Laboratory of Mathematical and Computational Biology, Department of Mathematics, Kyungpook National University, Daegu 702-701, Korea, School of Korean Medicine, Joint Research Center of Pusan National University-Fraunhofer IGB, Gyeongsangnam-do 626-870, Korea
  • Pages: 815-819
    |
    Published online on: July 8, 2010
       https://doi.org/10.3892/mmr.2010.325
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Abstract

The intracellular actin cytoskeleton is a central player in tumor cell migration and adhesion, and interacts with the extracellular matrix during the progression to metastasis. Although recent reports on motility events have revealed that the destabilization of actin affects cancer progression and hypoxia inducible factor-1α (HIF-1α) activity, little is known about the responsive activity of HIF-1α following actin disruption. Here, we demonstrate that the inhibition of actin polymerization or depolymerization attenuates HIF-1α expression independently of proteasomal degradation. The disruption of actin dynamics inactivates HIF-1α translational expression through p70S6K translational signaling; this is independent of p53 activation, suggesting that actin dysfunction-mediated HIF-1α destabilization may lead to the development of novel anticancer chemotherapeutic targets.

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Copy and paste a formatted citation
Spandidos Publications style
Shin IJ, Park BK, Ahn Y, Kim Y and An WG: Actin disruption inhibits hypoxia inducible factor-1α expression via inactivity of Mdm2-mediated p70S6K. Mol Med Rep 3: 815-819, 2010.
APA
Shin, I.J., Park, B.K., Ahn, Y., Kim, Y., & An, W.G. (2010). Actin disruption inhibits hypoxia inducible factor-1α expression via inactivity of Mdm2-mediated p70S6K. Molecular Medicine Reports, 3, 815-819. https://doi.org/10.3892/mmr.2010.325
MLA
Shin, I. J., Park, B. K., Ahn, Y., Kim, Y., An, W. G."Actin disruption inhibits hypoxia inducible factor-1α expression via inactivity of Mdm2-mediated p70S6K". Molecular Medicine Reports 3.5 (2010): 815-819.
Chicago
Shin, I. J., Park, B. K., Ahn, Y., Kim, Y., An, W. G."Actin disruption inhibits hypoxia inducible factor-1α expression via inactivity of Mdm2-mediated p70S6K". Molecular Medicine Reports 3, no. 5 (2010): 815-819. https://doi.org/10.3892/mmr.2010.325
Copy and paste a formatted citation
x
Spandidos Publications style
Shin IJ, Park BK, Ahn Y, Kim Y and An WG: Actin disruption inhibits hypoxia inducible factor-1α expression via inactivity of Mdm2-mediated p70S6K. Mol Med Rep 3: 815-819, 2010.
APA
Shin, I.J., Park, B.K., Ahn, Y., Kim, Y., & An, W.G. (2010). Actin disruption inhibits hypoxia inducible factor-1α expression via inactivity of Mdm2-mediated p70S6K. Molecular Medicine Reports, 3, 815-819. https://doi.org/10.3892/mmr.2010.325
MLA
Shin, I. J., Park, B. K., Ahn, Y., Kim, Y., An, W. G."Actin disruption inhibits hypoxia inducible factor-1α expression via inactivity of Mdm2-mediated p70S6K". Molecular Medicine Reports 3.5 (2010): 815-819.
Chicago
Shin, I. J., Park, B. K., Ahn, Y., Kim, Y., An, W. G."Actin disruption inhibits hypoxia inducible factor-1α expression via inactivity of Mdm2-mediated p70S6K". Molecular Medicine Reports 3, no. 5 (2010): 815-819. https://doi.org/10.3892/mmr.2010.325
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