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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2010 Volume 3 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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September-October 2010 Volume 3 Issue 5

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Article

Mass spectrometry-based proteomic analysis of Kashin-Beck disease

  • Authors:
    • Jianqiang Du
    • Xiaomin Wu
    • Huqin Zhang
    • Shuang Wang
    • Wuhong Tan
    • Xiong Guo

  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, 710061 Xi'an, P.R. China, Department of Orthodontics, Stomatological Hospital, College of Medicine, Xi'an Jiaotong University, 710061 Xi'an, P.R. China, Department of Orthodontics, Stomatological Hospital, College of Medicine, Xi'an Jiaotong University, 710061 Xi'an, P.R. China, Department of Public Health, School of Medicine, Xi'an Jiaotong University, 710061 Xi'an, P.R. China
  • Pages: 821-824
    |
    Published online on: July 8, 2010
       https://doi.org/10.3892/mmr.2010.327
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Abstract

Kashin-Beck disease (KBD) is a degenerative osteoarticular disease of unknown etiology. The management of KBD would benefit from the identification of the biomarkers related to this disease. In this study, mass spectrometry (MS)-based proteomic profiling was used to identify potential biomarkers of the disease. One hundred and sixteen serum samples of KBD cases and healthy controls were collected and analyzed. A framework for data analysis was implemented, which included normalization, denoising using undecimated discrete wavelet transforms, baseline subtraction, peak detection and alignment, non-parametric testing and classification by support vector machine. The method identified correlative mass points and obtained a discriminative pattern with 90.91% sensitivity and 82.61% specificity. The results of this study, although preliminary, suggest that further proteomics study may be useful with a larger number of appropriate specimens, careful experiment manipulation and improved MS techniques.

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Copy and paste a formatted citation
Spandidos Publications style
Du J, Wu X, Zhang H, Wang S, Tan W and Guo X: Mass spectrometry-based proteomic analysis of Kashin-Beck disease. Mol Med Rep 3: 821-824, 2010.
APA
Du, J., Wu, X., Zhang, H., Wang, S., Tan, W., & Guo, X. (2010). Mass spectrometry-based proteomic analysis of Kashin-Beck disease. Molecular Medicine Reports, 3, 821-824. https://doi.org/10.3892/mmr.2010.327
MLA
Du, J., Wu, X., Zhang, H., Wang, S., Tan, W., Guo, X."Mass spectrometry-based proteomic analysis of Kashin-Beck disease". Molecular Medicine Reports 3.5 (2010): 821-824.
Chicago
Du, J., Wu, X., Zhang, H., Wang, S., Tan, W., Guo, X."Mass spectrometry-based proteomic analysis of Kashin-Beck disease". Molecular Medicine Reports 3, no. 5 (2010): 821-824. https://doi.org/10.3892/mmr.2010.327
Copy and paste a formatted citation
x
Spandidos Publications style
Du J, Wu X, Zhang H, Wang S, Tan W and Guo X: Mass spectrometry-based proteomic analysis of Kashin-Beck disease. Mol Med Rep 3: 821-824, 2010.
APA
Du, J., Wu, X., Zhang, H., Wang, S., Tan, W., & Guo, X. (2010). Mass spectrometry-based proteomic analysis of Kashin-Beck disease. Molecular Medicine Reports, 3, 821-824. https://doi.org/10.3892/mmr.2010.327
MLA
Du, J., Wu, X., Zhang, H., Wang, S., Tan, W., Guo, X."Mass spectrometry-based proteomic analysis of Kashin-Beck disease". Molecular Medicine Reports 3.5 (2010): 821-824.
Chicago
Du, J., Wu, X., Zhang, H., Wang, S., Tan, W., Guo, X."Mass spectrometry-based proteomic analysis of Kashin-Beck disease". Molecular Medicine Reports 3, no. 5 (2010): 821-824. https://doi.org/10.3892/mmr.2010.327
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