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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2010 Volume 3 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September-October 2010 Volume 3 Issue 5

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Article

Transcriptional regulation of 1-cys peroxiredoxin by the proto-oncogene protein DEK

  • Authors:
    • Dong-Wook Kim
    • Ji-Young Kim
    • Sulji Choi
    • Sangmyung Rhee
    • Yoonsoo Hahn
    • Sang-Beom Seo

  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, College of Life Science, CHA University, Seongnam 463-836, Korea, Research Center for Biomolecules and Biosystems, Department of Life Science, College of Natural Sciences, Chung-Ang University, Seoul 156-756
  • Pages: 877-881
    |
    Published online on: July 26, 2010
       https://doi.org/10.3892/mmr.2010.346
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Abstract

The nuclear phosphoprotein DEK is abundantly present in cells and is implicated in diseases including leukemia and autoimmune disorders. DEK has three highly acidic amino acid domains and inhibits histone acetyltransferase activity by binding directly to histones. In a previous study, differentially regulated proteins under DEK knockdown conditions, including the up-regulated protein 1-cys peroxiredoxin (1-cys Prx), were identified by proteome analysis. Here, an in vivo reporter assay with short hairpin RNA-mediated DEK knockdown revealed that DEK negatively regulated 1-cys Prx transcription, and that the NF-κB subunit p65 had a synergistic effect on this DEK-mediated repression. Both proteins are recruited to the 1-cys Prx promoter region and regulate its transcription. Our study demonstrates that DEK modulates the transcriptional regulation of the target gene through protein interaction with other regulatory proteins.

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Copy and paste a formatted citation
Spandidos Publications style
Kim D, Kim J, Choi S, Rhee S, Hahn Y and Seo S: Transcriptional regulation of 1-cys peroxiredoxin by the proto-oncogene protein DEK. Mol Med Rep 3: 877-881, 2010.
APA
Kim, D., Kim, J., Choi, S., Rhee, S., Hahn, Y., & Seo, S. (2010). Transcriptional regulation of 1-cys peroxiredoxin by the proto-oncogene protein DEK. Molecular Medicine Reports, 3, 877-881. https://doi.org/10.3892/mmr.2010.346
MLA
Kim, D., Kim, J., Choi, S., Rhee, S., Hahn, Y., Seo, S."Transcriptional regulation of 1-cys peroxiredoxin by the proto-oncogene protein DEK". Molecular Medicine Reports 3.5 (2010): 877-881.
Chicago
Kim, D., Kim, J., Choi, S., Rhee, S., Hahn, Y., Seo, S."Transcriptional regulation of 1-cys peroxiredoxin by the proto-oncogene protein DEK". Molecular Medicine Reports 3, no. 5 (2010): 877-881. https://doi.org/10.3892/mmr.2010.346
Copy and paste a formatted citation
x
Spandidos Publications style
Kim D, Kim J, Choi S, Rhee S, Hahn Y and Seo S: Transcriptional regulation of 1-cys peroxiredoxin by the proto-oncogene protein DEK. Mol Med Rep 3: 877-881, 2010.
APA
Kim, D., Kim, J., Choi, S., Rhee, S., Hahn, Y., & Seo, S. (2010). Transcriptional regulation of 1-cys peroxiredoxin by the proto-oncogene protein DEK. Molecular Medicine Reports, 3, 877-881. https://doi.org/10.3892/mmr.2010.346
MLA
Kim, D., Kim, J., Choi, S., Rhee, S., Hahn, Y., Seo, S."Transcriptional regulation of 1-cys peroxiredoxin by the proto-oncogene protein DEK". Molecular Medicine Reports 3.5 (2010): 877-881.
Chicago
Kim, D., Kim, J., Choi, S., Rhee, S., Hahn, Y., Seo, S."Transcriptional regulation of 1-cys peroxiredoxin by the proto-oncogene protein DEK". Molecular Medicine Reports 3, no. 5 (2010): 877-881. https://doi.org/10.3892/mmr.2010.346
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