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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2010 Volume 3 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Promoter methylation profile of GSTP1 and RASSF1A in benign hyperplasia and metastatic prostate cancer patients in a Kashmiri population

  • Authors:
    • Nidda Syeed
    • A. Syed Sameer
    • Arif Hamid
    • Zafar A. Shah
    • Dil Afroze
    • Roohi Rasool
    • Mushtaq A. Siddiqi

  • View Affiliations / Copyright

    Affiliations: Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences, Kashmir 190011, India, Department of Urology, Sher-i-Kashmir Institute of Medical Sciences, Kashmir 190011, India
  • Pages: 883-887
    |
    Published online on: July 26, 2010
       https://doi.org/10.3892/mmr.2010.348
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Abstract

Promoter hypermethylation is a marginal approach to inactivating tumor suppressor genes in cancer. DNA hypermethylation is a well-recognized epigenetic malfunction observed in several malignancies, most predominantly in prostate cancer. Aberrant DNA methylation patterns are considered to be the earliest somatic genome changes in prostate cancer. The function of promoter hypermethylation in malignant transformation of the prostate has been widely studied, from its presence in benign hyperplasia (BHP) to development and to the advanced stages of tumor formation. In the present study, we examined the promoter hypermethylation status of the glutathione S-transferase P1 (GSTP1) and RASSF1A genes in 45 BHP samples, 50 proven prostate tumor samples and 80 normal samples. Hypermethylated GSTP1 was found in 29/50 (58.0%) prostate carcinoma cases and 12/45 (26.6%) BHP cases. The RASSF1A gene was methylated in 17/50 (34.0%) prostate cancer samples and 7/45 (15.5%) BHP samples. On the basis of these findings, we propose that the epigenetic regulation of the GSTP1 and RASSF1A genes through promoter hypermethylation may play a crucial role in the progression of prostate cancer, and has probable involvement in BHP.

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Copy and paste a formatted citation
Spandidos Publications style
Syeed N, Syed Sameer A, Hamid A, Shah ZA, Afroze D, Rasool R and Siddiqi MA: Promoter methylation profile of GSTP1 and RASSF1A in benign hyperplasia and metastatic prostate cancer patients in a Kashmiri population. Mol Med Rep 3: 883-887, 2010.
APA
Syeed, N., Syed Sameer, A., Hamid, A., Shah, Z.A., Afroze, D., Rasool, R., & Siddiqi, M.A. (2010). Promoter methylation profile of GSTP1 and RASSF1A in benign hyperplasia and metastatic prostate cancer patients in a Kashmiri population. Molecular Medicine Reports, 3, 883-887. https://doi.org/10.3892/mmr.2010.348
MLA
Syeed, N., Syed Sameer, A., Hamid, A., Shah, Z. A., Afroze, D., Rasool, R., Siddiqi, M. A."Promoter methylation profile of GSTP1 and RASSF1A in benign hyperplasia and metastatic prostate cancer patients in a Kashmiri population". Molecular Medicine Reports 3.5 (2010): 883-887.
Chicago
Syeed, N., Syed Sameer, A., Hamid, A., Shah, Z. A., Afroze, D., Rasool, R., Siddiqi, M. A."Promoter methylation profile of GSTP1 and RASSF1A in benign hyperplasia and metastatic prostate cancer patients in a Kashmiri population". Molecular Medicine Reports 3, no. 5 (2010): 883-887. https://doi.org/10.3892/mmr.2010.348
Copy and paste a formatted citation
x
Spandidos Publications style
Syeed N, Syed Sameer A, Hamid A, Shah ZA, Afroze D, Rasool R and Siddiqi MA: Promoter methylation profile of GSTP1 and RASSF1A in benign hyperplasia and metastatic prostate cancer patients in a Kashmiri population. Mol Med Rep 3: 883-887, 2010.
APA
Syeed, N., Syed Sameer, A., Hamid, A., Shah, Z.A., Afroze, D., Rasool, R., & Siddiqi, M.A. (2010). Promoter methylation profile of GSTP1 and RASSF1A in benign hyperplasia and metastatic prostate cancer patients in a Kashmiri population. Molecular Medicine Reports, 3, 883-887. https://doi.org/10.3892/mmr.2010.348
MLA
Syeed, N., Syed Sameer, A., Hamid, A., Shah, Z. A., Afroze, D., Rasool, R., Siddiqi, M. A."Promoter methylation profile of GSTP1 and RASSF1A in benign hyperplasia and metastatic prostate cancer patients in a Kashmiri population". Molecular Medicine Reports 3.5 (2010): 883-887.
Chicago
Syeed, N., Syed Sameer, A., Hamid, A., Shah, Z. A., Afroze, D., Rasool, R., Siddiqi, M. A."Promoter methylation profile of GSTP1 and RASSF1A in benign hyperplasia and metastatic prostate cancer patients in a Kashmiri population". Molecular Medicine Reports 3, no. 5 (2010): 883-887. https://doi.org/10.3892/mmr.2010.348
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