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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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November-December 2010 Volume 3 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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November-December 2010 Volume 3 Issue 6

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Article

Clinical significance of HSP27 expression in colorectal cancer

  • Authors:
    • Zhijin Yu
    • Junli Zhi
    • Xiaofeng Peng
    • Xuhui Zhong
    • Angao Xu

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Huizhou Municipal Central Hospital, Huicheng District, Huizhou City, P.R. China, College of Clinical Medicine, Guandong Pharmaceutical University, Guangzhou, P.R. China, Department of Pathology, Huizhou Municipal Central Hospital, Huicheng District, Huizhou City, P.R. China
  • Pages: 953-958
    |
    Published online on: September 27, 2010
       https://doi.org/10.3892/mmr.2010.372
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Abstract

The heat shock protein 27-kDa (HSP27) has been found overexpressed in several types of human cancer and is associated with treatment resistance and poor prognosis. Recent proteomic studies demonstrate that HSP27 is significantly overexpressed in colorectal cancer (CRC). However, the relationship between HSP27 expression and patient prognosis remains nascent. In the present study, we aimed to investigate the expression of HSP27 and its correlation with clinicopathological parameters in CRC patients. Dysregulated expression of HSP27 was observed in neoplastic lesions, and appears to be involved in disease progression. Immunohistochemical analysis showed that detectable HSP27 expression was found in 145/182 (79.7%) CRC cases. There was a significant correlation between HSP27 expression and TNM stage (P=0.003). Patients with low HSP27 expression had better survival than those with high HSP27 expression. Additionally, multivariate analysis indicated that HSP27 expression is an independent prognostic marker for CRC. These results suggest that elevated expression of HSP27 protein is a frequent event during the progression of CRC. HSP27 might be used as a valuable prognostic marker for patients with CRC.

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Copy and paste a formatted citation
Spandidos Publications style
Yu Z, Zhi J, Peng X, Zhong X and Xu A: Clinical significance of HSP27 expression in colorectal cancer. Mol Med Rep 3: 953-958, 2010.
APA
Yu, Z., Zhi, J., Peng, X., Zhong, X., & Xu, A. (2010). Clinical significance of HSP27 expression in colorectal cancer. Molecular Medicine Reports, 3, 953-958. https://doi.org/10.3892/mmr.2010.372
MLA
Yu, Z., Zhi, J., Peng, X., Zhong, X., Xu, A."Clinical significance of HSP27 expression in colorectal cancer". Molecular Medicine Reports 3.6 (2010): 953-958.
Chicago
Yu, Z., Zhi, J., Peng, X., Zhong, X., Xu, A."Clinical significance of HSP27 expression in colorectal cancer". Molecular Medicine Reports 3, no. 6 (2010): 953-958. https://doi.org/10.3892/mmr.2010.372
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Z, Zhi J, Peng X, Zhong X and Xu A: Clinical significance of HSP27 expression in colorectal cancer. Mol Med Rep 3: 953-958, 2010.
APA
Yu, Z., Zhi, J., Peng, X., Zhong, X., & Xu, A. (2010). Clinical significance of HSP27 expression in colorectal cancer. Molecular Medicine Reports, 3, 953-958. https://doi.org/10.3892/mmr.2010.372
MLA
Yu, Z., Zhi, J., Peng, X., Zhong, X., Xu, A."Clinical significance of HSP27 expression in colorectal cancer". Molecular Medicine Reports 3.6 (2010): 953-958.
Chicago
Yu, Z., Zhi, J., Peng, X., Zhong, X., Xu, A."Clinical significance of HSP27 expression in colorectal cancer". Molecular Medicine Reports 3, no. 6 (2010): 953-958. https://doi.org/10.3892/mmr.2010.372
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