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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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November-December 2010 Volume 3 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Suppression of A549 lung cancer cell migration by precursor let-7g microRNA

  • Authors:
    • Sungjin Park
    • Arash Minai-Tehrani
    • Cheng-Xiong Xu
    • Seung-Hee Chang
    • Min-Ah Woo
    • Mi-Suk Noh
    • Eun-Sun Lee
    • Hwang-Tae Lim
    • Gil-Hwan An
    • Kee-Ho Lee
    • Ha-Jung Sung
    • George R. Beck
    • Myung-Haing Cho

  • View Affiliations / Copyright

    Affiliations: Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea, Department of Nano Fusion Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, Department of Food Science and Technology, College of Agriculture and Life Sciences, Chungnam National University, Daejeon, Korea, Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences, Seoul, Korea, Institute of Fusion Technology, Hoseo University, Chungnam, Korea, Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA, USA
  • Pages: 1007-1013
    |
    Published online on: September 27, 2010
       https://doi.org/10.3892/mmr.2010.373
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Abstract

Let-7g miRNAs, short non-coding RNAs approximately 21 nucleotides long, repress protein translation by binding to the 3'UTR of target mRNAs. Aberrant expression of let-7g is associated with the poor prognosis of lung cancer patients. Compared to normal lung cells, let-7g expression is absent in non-small cell lung cancer (NSCLC) cells. Furthermore, K-Ras and HMGA2 are well known as targets of let-7g. In this study, we evaluated the potential role of precursor (pre)-let-7g in lung cancer cell metastasis, focusing on the two targets of let-7g, HMGA2 and K-Ras. We found that pre-let-7g inhibited the migration of A549 lung cancer cells through HMGA2-mediated E2F1 down-regulation. Thus, our results suggest that pre-let-7g could be used as a suitable target for the suppression of lung cancer cell migration.

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Copy and paste a formatted citation
Spandidos Publications style
Park S, Minai-Tehrani A, Xu C, Chang S, Woo M, Noh M, Lee E, Lim H, An G, Lee K, Lee K, et al: Suppression of A549 lung cancer cell migration by precursor let-7g microRNA. Mol Med Rep 3: 1007-1013, 2010.
APA
Park, S., Minai-Tehrani, A., Xu, C., Chang, S., Woo, M., Noh, M. ... Cho, M. (2010). Suppression of A549 lung cancer cell migration by precursor let-7g microRNA. Molecular Medicine Reports, 3, 1007-1013. https://doi.org/10.3892/mmr.2010.373
MLA
Park, S., Minai-Tehrani, A., Xu, C., Chang, S., Woo, M., Noh, M., Lee, E., Lim, H., An, G., Lee, K., Sung, H., Beck, G. R., Cho, M."Suppression of A549 lung cancer cell migration by precursor let-7g microRNA". Molecular Medicine Reports 3.6 (2010): 1007-1013.
Chicago
Park, S., Minai-Tehrani, A., Xu, C., Chang, S., Woo, M., Noh, M., Lee, E., Lim, H., An, G., Lee, K., Sung, H., Beck, G. R., Cho, M."Suppression of A549 lung cancer cell migration by precursor let-7g microRNA". Molecular Medicine Reports 3, no. 6 (2010): 1007-1013. https://doi.org/10.3892/mmr.2010.373
Copy and paste a formatted citation
x
Spandidos Publications style
Park S, Minai-Tehrani A, Xu C, Chang S, Woo M, Noh M, Lee E, Lim H, An G, Lee K, Lee K, et al: Suppression of A549 lung cancer cell migration by precursor let-7g microRNA. Mol Med Rep 3: 1007-1013, 2010.
APA
Park, S., Minai-Tehrani, A., Xu, C., Chang, S., Woo, M., Noh, M. ... Cho, M. (2010). Suppression of A549 lung cancer cell migration by precursor let-7g microRNA. Molecular Medicine Reports, 3, 1007-1013. https://doi.org/10.3892/mmr.2010.373
MLA
Park, S., Minai-Tehrani, A., Xu, C., Chang, S., Woo, M., Noh, M., Lee, E., Lim, H., An, G., Lee, K., Sung, H., Beck, G. R., Cho, M."Suppression of A549 lung cancer cell migration by precursor let-7g microRNA". Molecular Medicine Reports 3.6 (2010): 1007-1013.
Chicago
Park, S., Minai-Tehrani, A., Xu, C., Chang, S., Woo, M., Noh, M., Lee, E., Lim, H., An, G., Lee, K., Sung, H., Beck, G. R., Cho, M."Suppression of A549 lung cancer cell migration by precursor let-7g microRNA". Molecular Medicine Reports 3, no. 6 (2010): 1007-1013. https://doi.org/10.3892/mmr.2010.373
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