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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2011 Volume 4 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Differentially expressed genes in Men1 knockout and wild‑type embryoid bodies for pancreatic islet development

  • Authors:
    • Hong-Li Zhang
    • Wen-Yi Li
    • Cui-Ping Zhang
    • Ya-Xin Zhu
    • Ling Wu
    • Hong-Mei Long
    • Guo Li
    • Min Luo

  • View Affiliations / Copyright

    Affiliations: Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 200025 Shanghai, P.R. China, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197 Ruijin 2nd Road, 200025, Shanghai, P.R. China
  • Pages: 301-305
    |
    Published online on: January 3, 2011
       https://doi.org/10.3892/mmr.2011.409
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Abstract

The Men1 gene has been identified as the gene responsible for MEN-1, a hereditary syndrome transmitted as an autosomal dominant trait. Disruption of the Men1 gene results in defects in the development of multiple organs, including pancreatic islets. Homozygous disruption of Men1 in mice causes embryonic lethality, making it difficult to determine the genes involved in defects of pancreatic islets during embryonic development. In this study, embryoid bodies formed from null mutant (Men1-/-) and wild-type (Men1+/+) embryonic stem cells were used as a model system to investigate the effects of the Men1 gene on pancreatic islet development. Using RT-PCR, SOX17, FOXA2 and NKX2.2 were found to be differentially expressed between the two embryoid bodies. Additionally, the gene expression profile of these Men1-/- embryoid bodies was characterized in detail by DNA microarray techniques, and a series of putative menin-targeted genes was identified. Our study suggests a critical role for Men1 in pancreatic islet development, and indicates that genes such as SOX17, FOXA2, NKX2.2 and SOX4 are potential targets of Men1.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Li W, Zhang C, Zhu Y, Wu L, Long H, Li G and Luo M: Differentially expressed genes in Men1 knockout and wild‑type embryoid bodies for pancreatic islet development. Mol Med Rep 4: 301-305, 2011.
APA
Zhang, H., Li, W., Zhang, C., Zhu, Y., Wu, L., Long, H. ... Luo, M. (2011). Differentially expressed genes in Men1 knockout and wild‑type embryoid bodies for pancreatic islet development. Molecular Medicine Reports, 4, 301-305. https://doi.org/10.3892/mmr.2011.409
MLA
Zhang, H., Li, W., Zhang, C., Zhu, Y., Wu, L., Long, H., Li, G., Luo, M."Differentially expressed genes in Men1 knockout and wild‑type embryoid bodies for pancreatic islet development". Molecular Medicine Reports 4.2 (2011): 301-305.
Chicago
Zhang, H., Li, W., Zhang, C., Zhu, Y., Wu, L., Long, H., Li, G., Luo, M."Differentially expressed genes in Men1 knockout and wild‑type embryoid bodies for pancreatic islet development". Molecular Medicine Reports 4, no. 2 (2011): 301-305. https://doi.org/10.3892/mmr.2011.409
Copy and paste a formatted citation
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Spandidos Publications style
Zhang H, Li W, Zhang C, Zhu Y, Wu L, Long H, Li G and Luo M: Differentially expressed genes in Men1 knockout and wild‑type embryoid bodies for pancreatic islet development. Mol Med Rep 4: 301-305, 2011.
APA
Zhang, H., Li, W., Zhang, C., Zhu, Y., Wu, L., Long, H. ... Luo, M. (2011). Differentially expressed genes in Men1 knockout and wild‑type embryoid bodies for pancreatic islet development. Molecular Medicine Reports, 4, 301-305. https://doi.org/10.3892/mmr.2011.409
MLA
Zhang, H., Li, W., Zhang, C., Zhu, Y., Wu, L., Long, H., Li, G., Luo, M."Differentially expressed genes in Men1 knockout and wild‑type embryoid bodies for pancreatic islet development". Molecular Medicine Reports 4.2 (2011): 301-305.
Chicago
Zhang, H., Li, W., Zhang, C., Zhu, Y., Wu, L., Long, H., Li, G., Luo, M."Differentially expressed genes in Men1 knockout and wild‑type embryoid bodies for pancreatic islet development". Molecular Medicine Reports 4, no. 2 (2011): 301-305. https://doi.org/10.3892/mmr.2011.409
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