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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2011 Volume 4 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

(-)-Epigallocatechin gallate inhibits thyroid hormone‑stimulated osteocalcin synthesis in osteoblasts

  • Authors:
    • Kenji Kato
    • Takanobu Otsuka
    • Seiji Adachi
    • Rie Matsushima-Nishiwaki
    • Hideo Natsume
    • Osamu Kozawa
    • Haruhiko Tokuda

  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467‑8601, Japan, Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan, Department of Clinical Laboratory, National Center for Geriatrics and Gerontology, Aichi 474-8511, Japan
  • Pages: 297-300
    |
    Published online on: January 11, 2011
       https://doi.org/10.3892/mmr.2011.421
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Abstract

It is recognized that catechin possesses beneficial properties for bone metabolism. We previously revealed that triiodothyronine (T3)-activated p38 mitogen-activated protein (MAP) kinase, but not p44/p42 MAP kinase, is involved in the synthesis of osteocalcin in osteoblast-like MC3T3-E1 cells. In the present study, we investigated the effect of (-)-epigallocatechin gallate (EGCG), the predominant green tea polyphenol, on the synthesis of osteocalcin in MC3T3-E1 cells. EGCG significantly suppressed T3-stimulated osteocalcin synthesis. The inhibitory effect of EGCG was dose-dependent in the range of 3 to 30 µM. On the other hand, T3-induced phosphorylation of p38 MAP kinase was not affected by EGCG. EGCG profoundly inhibited T3-stimulated transcriptional activity. These results strongly suggest that EGCG suppresses T3-stimulated osteocalcin synthesis upstream of the transcriptional level in osteoblast-like MC3T3-E1 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Kato K, Otsuka T, Adachi S, Matsushima-Nishiwaki R, Natsume H, Kozawa O and Tokuda H: (-)-Epigallocatechin gallate inhibits thyroid hormone‑stimulated osteocalcin synthesis in osteoblasts. Mol Med Rep 4: 297-300, 2011.
APA
Kato, K., Otsuka, T., Adachi, S., Matsushima-Nishiwaki, R., Natsume, H., Kozawa, O., & Tokuda, H. (2011). (-)-Epigallocatechin gallate inhibits thyroid hormone‑stimulated osteocalcin synthesis in osteoblasts. Molecular Medicine Reports, 4, 297-300. https://doi.org/10.3892/mmr.2011.421
MLA
Kato, K., Otsuka, T., Adachi, S., Matsushima-Nishiwaki, R., Natsume, H., Kozawa, O., Tokuda, H."(-)-Epigallocatechin gallate inhibits thyroid hormone‑stimulated osteocalcin synthesis in osteoblasts". Molecular Medicine Reports 4.2 (2011): 297-300.
Chicago
Kato, K., Otsuka, T., Adachi, S., Matsushima-Nishiwaki, R., Natsume, H., Kozawa, O., Tokuda, H."(-)-Epigallocatechin gallate inhibits thyroid hormone‑stimulated osteocalcin synthesis in osteoblasts". Molecular Medicine Reports 4, no. 2 (2011): 297-300. https://doi.org/10.3892/mmr.2011.421
Copy and paste a formatted citation
x
Spandidos Publications style
Kato K, Otsuka T, Adachi S, Matsushima-Nishiwaki R, Natsume H, Kozawa O and Tokuda H: (-)-Epigallocatechin gallate inhibits thyroid hormone‑stimulated osteocalcin synthesis in osteoblasts. Mol Med Rep 4: 297-300, 2011.
APA
Kato, K., Otsuka, T., Adachi, S., Matsushima-Nishiwaki, R., Natsume, H., Kozawa, O., & Tokuda, H. (2011). (-)-Epigallocatechin gallate inhibits thyroid hormone‑stimulated osteocalcin synthesis in osteoblasts. Molecular Medicine Reports, 4, 297-300. https://doi.org/10.3892/mmr.2011.421
MLA
Kato, K., Otsuka, T., Adachi, S., Matsushima-Nishiwaki, R., Natsume, H., Kozawa, O., Tokuda, H."(-)-Epigallocatechin gallate inhibits thyroid hormone‑stimulated osteocalcin synthesis in osteoblasts". Molecular Medicine Reports 4.2 (2011): 297-300.
Chicago
Kato, K., Otsuka, T., Adachi, S., Matsushima-Nishiwaki, R., Natsume, H., Kozawa, O., Tokuda, H."(-)-Epigallocatechin gallate inhibits thyroid hormone‑stimulated osteocalcin synthesis in osteoblasts". Molecular Medicine Reports 4, no. 2 (2011): 297-300. https://doi.org/10.3892/mmr.2011.421
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