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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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March-April 2011 Volume 4 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Gefitinib induces mitochondrial-dependent apoptosis in Saccharomyces cerevisiae

  • Authors:
    • Jing Wu
    • Rou Min
    • Minchen Wu
    • Wei Chen

  • View Affiliations / Copyright

    Affiliations: Department of Pharmaceutical Engineering, School of Medicine and Pharmaceutics, Jiangnan University, Jiangsu 214122, P.R. China
  • Pages: 357-362
    |
    Published online on: January 18, 2011
       https://doi.org/10.3892/mmr.2011.427
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Abstract

Gefitinib, a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, has been clinically demonstrated to be effective in certain cancer cell types. In the present study, using the yeast Saccharomyces cerevisiae as a model, gefitinib-induced apoptotic cell death was demonstrated. Gefitinib inhibited yeast cell proliferation and ultimately led to cell death in a time- and dose-dependent manner. Furthermore, when cells were exposed to 15 µM gefitinib, typical apoptotic markers, including phosphatidylserine exposure, DNA fragmentation, reactive oxygen species production and decrease in mitochondrial membrane potential, were observed. The Δcyc3 strain deleted in cyt c heme lyase and the rho0 mutant strain lacking mtDNA-delayed cell death, provided further evidence that the yeast cell death process involved the mitochondria. Thus, these findings suggest that gefitinib induces apoptosis in yeast cells through a mitochondrial-dependent pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Wu J, Min R, Wu M and Chen W: Gefitinib induces mitochondrial-dependent apoptosis in Saccharomyces cerevisiae. Mol Med Rep 4: 357-362, 2011.
APA
Wu, J., Min, R., Wu, M., & Chen, W. (2011). Gefitinib induces mitochondrial-dependent apoptosis in Saccharomyces cerevisiae. Molecular Medicine Reports, 4, 357-362. https://doi.org/10.3892/mmr.2011.427
MLA
Wu, J., Min, R., Wu, M., Chen, W."Gefitinib induces mitochondrial-dependent apoptosis in Saccharomyces cerevisiae". Molecular Medicine Reports 4.2 (2011): 357-362.
Chicago
Wu, J., Min, R., Wu, M., Chen, W."Gefitinib induces mitochondrial-dependent apoptosis in Saccharomyces cerevisiae". Molecular Medicine Reports 4, no. 2 (2011): 357-362. https://doi.org/10.3892/mmr.2011.427
Copy and paste a formatted citation
x
Spandidos Publications style
Wu J, Min R, Wu M and Chen W: Gefitinib induces mitochondrial-dependent apoptosis in Saccharomyces cerevisiae. Mol Med Rep 4: 357-362, 2011.
APA
Wu, J., Min, R., Wu, M., & Chen, W. (2011). Gefitinib induces mitochondrial-dependent apoptosis in Saccharomyces cerevisiae. Molecular Medicine Reports, 4, 357-362. https://doi.org/10.3892/mmr.2011.427
MLA
Wu, J., Min, R., Wu, M., Chen, W."Gefitinib induces mitochondrial-dependent apoptosis in Saccharomyces cerevisiae". Molecular Medicine Reports 4.2 (2011): 357-362.
Chicago
Wu, J., Min, R., Wu, M., Chen, W."Gefitinib induces mitochondrial-dependent apoptosis in Saccharomyces cerevisiae". Molecular Medicine Reports 4, no. 2 (2011): 357-362. https://doi.org/10.3892/mmr.2011.427
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