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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-April 2011 Volume 4 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March-April 2011 Volume 4 Issue 2

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Article

A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells

  • Authors:
    • Jie Yuan
    • Zhenjian He
    • Jueheng Wu
    • Yongcheng Lin
    • Xun Zhu

  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou 510080, P.R. China, Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-Sen University), Bureau of Education, Guangzhou 510080, P.R. China
  • Pages: 261-265
    |
    Published online on: January 25, 2011
       https://doi.org/10.3892/mmr.2011.434
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Abstract

1403P‑3 is a novel anthracenedione derivative isolated from the secondary metabolites of endophytic fungus from the South China Sea. In previous studies, 1403P-3 was found to exhibit potent cytotoxicity against human cancer cells, but its molecular target and the mechanisms mediating its cytotoxicity remain unknown. In this study, we showed that 1403P-3 markedly inhibited the survival of the human breast cancer cells MCF-7 and MDA-MB-435 in a dose-dependent manner, with an IC50 of 9.5 and 7.6 µM, respectively. Apoptosis induced by 1403P-3 was detected, as indicated by Annexin V-FITC/PI staining, elevated activated caspase-8 and -9, and cleavaged PARP determined by Western blot analysis. It is of note that the phosphorylation level of Akt was significantly reduced in 1403P-3-treated cells in a dose- and time-dependent manner. Taken together, our data demonstrated that 1403P-3 induced breast cancer cell apoptosis by blocking Akt activation, suggesting that 1403P-3 may be a promising candidate compound for anti-tumor drug development.

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Copy and paste a formatted citation
Spandidos Publications style
Yuan J, He Z, Wu J, Lin Y and Zhu X: A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells. Mol Med Rep 4: 261-265, 2011.
APA
Yuan, J., He, Z., Wu, J., Lin, Y., & Zhu, X. (2011). A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells. Molecular Medicine Reports, 4, 261-265. https://doi.org/10.3892/mmr.2011.434
MLA
Yuan, J., He, Z., Wu, J., Lin, Y., Zhu, X."A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells". Molecular Medicine Reports 4.2 (2011): 261-265.
Chicago
Yuan, J., He, Z., Wu, J., Lin, Y., Zhu, X."A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells". Molecular Medicine Reports 4, no. 2 (2011): 261-265. https://doi.org/10.3892/mmr.2011.434
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan J, He Z, Wu J, Lin Y and Zhu X: A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells. Mol Med Rep 4: 261-265, 2011.
APA
Yuan, J., He, Z., Wu, J., Lin, Y., & Zhu, X. (2011). A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells. Molecular Medicine Reports, 4, 261-265. https://doi.org/10.3892/mmr.2011.434
MLA
Yuan, J., He, Z., Wu, J., Lin, Y., Zhu, X."A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells". Molecular Medicine Reports 4.2 (2011): 261-265.
Chicago
Yuan, J., He, Z., Wu, J., Lin, Y., Zhu, X."A novel adriamycin analogue derived from marine microbes induces apoptosis by blocking Akt activation in human breast cancer cells". Molecular Medicine Reports 4, no. 2 (2011): 261-265. https://doi.org/10.3892/mmr.2011.434
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