BTEB2 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model

  • Authors:
    • De Li
    • Shuangtao Ma
    • Yongjian Yang
    • Dachun Yang
    • Gang Li
    • Xin Zhang
    • Jun Zhu
    • Meiqin Sun
    • Bing Tang
  • View Affiliations

  • Published online on: February 14, 2011     https://doi.org/10.3892/mmr.2011.438
  • Pages: 413-417
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Abstract

Basic transcription element-binding protein 2 (BTEB2) is a regulator of the proliferation and phenotypic changes of vascular smooth muscle cells (SMCs). The aim of the present study was to determine whether or not BTEB2 knockdown inhibits balloon injury-induced neointimal hyperplasia attributed to the proliferation and phenotypic changes of vascular SMCs. We found that the knockdown of BTEB2 with antisense oligonucleotides (Ad-As-BTEB2) significantly reduced the intima/media ratio compared to uninjured arteries and vessels treated with Ad-LacZ. Knockdown of BTEB2 suppresses the proliferation of cultured vascular SMCs, concurrent with the down-regulation of proliferating cell nuclear antigen, angiotensin II type 1 receptor and platelet-derived growth factor BB. In addition, BTEB2 knockdown caused the up-regulation of the differentiation marker smooth muscle α-actin and down-regulation of the dedifferentiation marker embryonic smooth muscle myosin heavy chain. The present study provides direct evidence that BTEB2 plays a critical role in balloon injury-induced neointimal hyperplasia, which is closely linked to vascular SMC proliferation and phenotypic modulation. This study highlights the fact that BTEB2 may be a potential target for the prevention of restenosis after vascular intervention.

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May-June 2011
Volume 4 Issue 3

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Spandidos Publications style
Li D, Ma S, Yang Y, Yang D, Li G, Zhang X, Zhu J, Sun M and Tang B: BTEB2 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model. Mol Med Rep 4: 413-417, 2011.
APA
Li, D., Ma, S., Yang, Y., Yang, D., Li, G., Zhang, X. ... Tang, B. (2011). BTEB2 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model. Molecular Medicine Reports, 4, 413-417. https://doi.org/10.3892/mmr.2011.438
MLA
Li, D., Ma, S., Yang, Y., Yang, D., Li, G., Zhang, X., Zhu, J., Sun, M., Tang, B."BTEB2 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model". Molecular Medicine Reports 4.3 (2011): 413-417.
Chicago
Li, D., Ma, S., Yang, Y., Yang, D., Li, G., Zhang, X., Zhu, J., Sun, M., Tang, B."BTEB2 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model". Molecular Medicine Reports 4, no. 3 (2011): 413-417. https://doi.org/10.3892/mmr.2011.438