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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2011 Volume 4 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Expression and potential role of chemokine receptor CXCR4 in human bladder carcinoma cell lines with different metastatic ability

  • Authors:
    • Haifeng Wang
    • Delin Yang
    • Kai Wang
    • Jiansong Wang

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Second Affiliated Hospital of Kunming Medical College, Kunming 650101, P.R. China
  • Pages: 525-528
    |
    Published online on: February 18, 2011
       https://doi.org/10.3892/mmr.2011.440
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Abstract

The aim of the present study was to investigate the expression of the chemokine receptor CXCR4 in human bladder carcinoma cells and its possible role in their metastatic growth in vitro. Immunofluorescent imaging and flow cytometry were performed to examine the expression of CXCR4 in the EJ and EJ-M3 cell lines. A highly specific CXCR4 antagonist, AMD3100, was used to inhibit metastatic growth, as assessed by an in vitro invasion assay. The expression of CXCR4 protein was mainly observed in the cytoplasm of the two bladder carcinoma cell sublines. CXCR4 expression was increased in the EJ-M3 cell line compared to the EJ cells. Differences in the CXCR4 protein expression rates between the EJ-M3 cell line (55.7±10.35%) and EJ cell line (25.4±4.69%) were significant (P<0.05). The CXCR4 antagonist AMD3100 partially inhibited the metastasis of the EJ-M3 cells, which had higher CXCR4 expression (56±8.96) than the control EJ cells (118±6.56) (P<0.05). In conclusion, the high in vitro metastatic potential of human bladder carcinoma cell sublines is closely associated with increased CXCR4 expression, and is inhibited by a specific CXCR4 antagonist.

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Yang D, Wang K and Wang J: Expression and potential role of chemokine receptor CXCR4 in human bladder carcinoma cell lines with different metastatic ability. Mol Med Rep 4: 525-528, 2011.
APA
Wang, H., Yang, D., Wang, K., & Wang, J. (2011). Expression and potential role of chemokine receptor CXCR4 in human bladder carcinoma cell lines with different metastatic ability. Molecular Medicine Reports, 4, 525-528. https://doi.org/10.3892/mmr.2011.440
MLA
Wang, H., Yang, D., Wang, K., Wang, J."Expression and potential role of chemokine receptor CXCR4 in human bladder carcinoma cell lines with different metastatic ability". Molecular Medicine Reports 4.3 (2011): 525-528.
Chicago
Wang, H., Yang, D., Wang, K., Wang, J."Expression and potential role of chemokine receptor CXCR4 in human bladder carcinoma cell lines with different metastatic ability". Molecular Medicine Reports 4, no. 3 (2011): 525-528. https://doi.org/10.3892/mmr.2011.440
Copy and paste a formatted citation
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Spandidos Publications style
Wang H, Yang D, Wang K and Wang J: Expression and potential role of chemokine receptor CXCR4 in human bladder carcinoma cell lines with different metastatic ability. Mol Med Rep 4: 525-528, 2011.
APA
Wang, H., Yang, D., Wang, K., & Wang, J. (2011). Expression and potential role of chemokine receptor CXCR4 in human bladder carcinoma cell lines with different metastatic ability. Molecular Medicine Reports, 4, 525-528. https://doi.org/10.3892/mmr.2011.440
MLA
Wang, H., Yang, D., Wang, K., Wang, J."Expression and potential role of chemokine receptor CXCR4 in human bladder carcinoma cell lines with different metastatic ability". Molecular Medicine Reports 4.3 (2011): 525-528.
Chicago
Wang, H., Yang, D., Wang, K., Wang, J."Expression and potential role of chemokine receptor CXCR4 in human bladder carcinoma cell lines with different metastatic ability". Molecular Medicine Reports 4, no. 3 (2011): 525-528. https://doi.org/10.3892/mmr.2011.440
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