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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2011 Volume 4 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

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Article

Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1

  • Authors:
    • Rui Cheng
    • Jie Qiu
    • Xiao-Yu Zhou
    • Xiao-Hui Chen
    • Chun Zhu
    • Da‑Ni Qin
    • Ji-Wu Wang
    • Yu-Hui Ni
    • Chen-Bo Ji
    • Xi-Rong Guo

  • View Affiliations / Copyright

    Affiliations: Department of Newborn Infants, Nanjing Children's Hospital of Nanjing Medical University, Nanjing 210008, P.R. China, Department of Pediatrics, Nanjing Maternity and Child Health Hospital of Nanjing Medical University, Nanjing 210004, P.R. China, Allele Biotechnology and Pharmaceuticals Inc., San Diego, CA 92121, USA, Institute of Pediatrics of Nanjing Medical University, Nanjing 210029, P.R. China
  • Pages: 519-523
    |
    Published online on: February 22, 2011
       https://doi.org/10.3892/mmr.2011.443
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Abstract

The aim of this study was to investigate whether the early endosome antigen 1 (EEA1) and/or PI3K pathway is involved in the molecular mechanisms underlying the effects of the six-transmembrane protein of prostate 4 (STEAP4; also called STAMP2 and TIARP) on the insulin sensitivity of human adipocytes. Our data demonstrated that siRNA-mediated STEAP4 deficiency significantly decreased insulin-stimulated glucose transport in mature human adipocytes by decreasing GLUT4 translocation to the plasma membrane through attenuated Akt phosphorylation. We further found that EEA1 may not be involved in the mechanisms underlying the effects of STEAP4 on insulin-stimulated glucose uptake and GLUT4 translocation, as indicated by the results that i) STEAP4 does not alter the effects of EEA1 on insulin-stimulated glucose uptake and GLUT4 translocation; ii) STEAP4 does not modify the expression of EEA1 protein; and iii) STEAP4 does not interact with EEA1 according to FRET analysis. In conclusion, this study revealed that the knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via the attenuated phosphorylation of Akt, independent of the effects of EEA1.

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Copy and paste a formatted citation
Spandidos Publications style
Cheng R, Qiu J, Zhou X, Chen X, Zhu C, Qin DN, Wang J, Ni Y, Ji C, Guo X, Guo X, et al: Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1. Mol Med Rep 4: 519-523, 2011.
APA
Cheng, R., Qiu, J., Zhou, X., Chen, X., Zhu, C., Qin, D. ... Guo, X. (2011). Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1. Molecular Medicine Reports, 4, 519-523. https://doi.org/10.3892/mmr.2011.443
MLA
Cheng, R., Qiu, J., Zhou, X., Chen, X., Zhu, C., Qin, D., Wang, J., Ni, Y., Ji, C., Guo, X."Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1". Molecular Medicine Reports 4.3 (2011): 519-523.
Chicago
Cheng, R., Qiu, J., Zhou, X., Chen, X., Zhu, C., Qin, D., Wang, J., Ni, Y., Ji, C., Guo, X."Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1". Molecular Medicine Reports 4, no. 3 (2011): 519-523. https://doi.org/10.3892/mmr.2011.443
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng R, Qiu J, Zhou X, Chen X, Zhu C, Qin DN, Wang J, Ni Y, Ji C, Guo X, Guo X, et al: Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1. Mol Med Rep 4: 519-523, 2011.
APA
Cheng, R., Qiu, J., Zhou, X., Chen, X., Zhu, C., Qin, D. ... Guo, X. (2011). Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1. Molecular Medicine Reports, 4, 519-523. https://doi.org/10.3892/mmr.2011.443
MLA
Cheng, R., Qiu, J., Zhou, X., Chen, X., Zhu, C., Qin, D., Wang, J., Ni, Y., Ji, C., Guo, X."Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1". Molecular Medicine Reports 4.3 (2011): 519-523.
Chicago
Cheng, R., Qiu, J., Zhou, X., Chen, X., Zhu, C., Qin, D., Wang, J., Ni, Y., Ji, C., Guo, X."Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1". Molecular Medicine Reports 4, no. 3 (2011): 519-523. https://doi.org/10.3892/mmr.2011.443
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