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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-June 2011 Volume 4 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May-June 2011 Volume 4 Issue 3

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Article

Clinical significance of CXCL16/CXCR6 expression in patients with prostate cancer

  • Authors:
    • Hong Koo Ha
    • Wan Lee
    • Hyun Jun Park
    • Sang Don Lee
    • Jeong Zoo Lee
    • Moon Kee Chung

  • View Affiliations / Copyright

    Affiliations: Department of Urology and Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan 602739, Republic of Korea
  • Pages: 419-424
    |
    Published online on: March 4, 2011
       https://doi.org/10.3892/mmr.2011.446
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Abstract

We hypothesized that the CXCL16-CXCR6 ligand-receptor system may play an important role in prostate cancer progression. Levels of CXCL16 and CXCR6 expression were evaluated in prostate cancer cell lines (PC-3 and LNCaP) and normal prostate epithelial cells (PrEC), as well as in tissues from 354 patients. The immunohistochemical expression of CXCL16/CXCR6 was greater in the PC-3/LNCaP cells than in the PrEC cell line. The expression of CXCL16/CXCR6 was significantly higher in prostate cancer than in benign prostatic hypertrophy. Using RT-PCR, the expression of CXCL16/CXCR6 was found to be greater in the PC-3/LNCaP cells than in the PrEC cell line. CXCL16/CXCR6 was weakly detected in lung and liver tissues, whereas CXCL16 was highly expressed in specimens of bone metastasis. CXCL16 immunostaining was related to Gleason score, T stage, tumor volume, perineural invasion and lymph node metastasis. However, biochemical PSA recurrence was not related to the expression of CXCL16/CXCR6. High CXCL16/CXCR6 expression may be related to aggressive cancer behavior, and high CXCL16 expression to bone metastases.

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Copy and paste a formatted citation
Spandidos Publications style
Ha HK, Lee W, Park HJ, Lee SD, Lee JZ and Chung MK: Clinical significance of CXCL16/CXCR6 expression in patients with prostate cancer. Mol Med Rep 4: 419-424, 2011.
APA
Ha, H.K., Lee, W., Park, H.J., Lee, S.D., Lee, J.Z., & Chung, M.K. (2011). Clinical significance of CXCL16/CXCR6 expression in patients with prostate cancer. Molecular Medicine Reports, 4, 419-424. https://doi.org/10.3892/mmr.2011.446
MLA
Ha, H. K., Lee, W., Park, H. J., Lee, S. D., Lee, J. Z., Chung, M. K."Clinical significance of CXCL16/CXCR6 expression in patients with prostate cancer". Molecular Medicine Reports 4.3 (2011): 419-424.
Chicago
Ha, H. K., Lee, W., Park, H. J., Lee, S. D., Lee, J. Z., Chung, M. K."Clinical significance of CXCL16/CXCR6 expression in patients with prostate cancer". Molecular Medicine Reports 4, no. 3 (2011): 419-424. https://doi.org/10.3892/mmr.2011.446
Copy and paste a formatted citation
x
Spandidos Publications style
Ha HK, Lee W, Park HJ, Lee SD, Lee JZ and Chung MK: Clinical significance of CXCL16/CXCR6 expression in patients with prostate cancer. Mol Med Rep 4: 419-424, 2011.
APA
Ha, H.K., Lee, W., Park, H.J., Lee, S.D., Lee, J.Z., & Chung, M.K. (2011). Clinical significance of CXCL16/CXCR6 expression in patients with prostate cancer. Molecular Medicine Reports, 4, 419-424. https://doi.org/10.3892/mmr.2011.446
MLA
Ha, H. K., Lee, W., Park, H. J., Lee, S. D., Lee, J. Z., Chung, M. K."Clinical significance of CXCL16/CXCR6 expression in patients with prostate cancer". Molecular Medicine Reports 4.3 (2011): 419-424.
Chicago
Ha, H. K., Lee, W., Park, H. J., Lee, S. D., Lee, J. Z., Chung, M. K."Clinical significance of CXCL16/CXCR6 expression in patients with prostate cancer". Molecular Medicine Reports 4, no. 3 (2011): 419-424. https://doi.org/10.3892/mmr.2011.446
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