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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2011 Volume 4 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers

  • Authors:
    • Takayuki Sonoyama
    • Akiko Sakai
    • Yuichiro Mita
    • Yukiko Yasuda
    • Hirofumi Kawamoto
    • Takahito Yagi
    • Masao Yoshioka
    • Tetsushige Mimura
    • Kei Nakachi
    • Mamoru Ouchida
    • Kazuhide Yamamoto
    • Kenji Shimizu

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Okayama 700-8558, Japan, Department of Molecular Genetics, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Okayama 700-8558, Japan, Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, Okayama 700-8558, Japan, Okayama Saiseikai Hospital, Okayama 700-8511, Japan, Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima 732-0815, Japan
  • Pages: 489-495
    |
    Published online on: March 8, 2011
       https://doi.org/10.3892/mmr.2011.449
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Abstract

Tumor protein p53 (TP53) is the best-known tumor suppressor gene and plays a crucial role in carcinogenesis. The TP53 Arg 72 Pro polymorphism has been reported to be a risk factor for several types of cancer, but its association with pancreatic cancer has not been fully evaluated. Therefore, we investigated the effects of this polymorphism on pancreatic cancer in relation to smoking and drinking habits by examining the distribution of the SNP genotypes in 226 pancreatic cancer patients and 448 healthy controls. The frequencies of Arg/Arg, Arg/Pro and Pro/Pro were found to be 37, 49 and 15% in the pancreatic cancer cases and 44, 46 and 10% in the controls, respectively. Compared to the controls with the Arg/Arg genotype, cases with Pro/Pro homozygosity exhibited a significantly increased risk [adjusted odds ratio (OR)=1.70; 95% confidence interval (CI) 1.01-2.88]. In stratified studies, the association was particularly strong in males (OR=2.62; 95% CI 1.32-5.23), particularly in those smoking in excess of 20 pack-years and drinking in excess of 23 g ethanol/day (OR=5.02; 95% CI 1.12-22.51). We found that the TP53 Pro/Pro genotype compared to the Arg/Arg genotype had a profound effect on pancreatic cancer risk among males, particularly among heavy smokers and excessive alcohol drinkers.

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Copy and paste a formatted citation
Spandidos Publications style
Sonoyama T, Sakai A, Mita Y, Yasuda Y, Kawamoto H, Yagi T, Yoshioka M, Mimura T, Nakachi K, Ouchida M, Ouchida M, et al: TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers. Mol Med Rep 4: 489-495, 2011.
APA
Sonoyama, T., Sakai, A., Mita, Y., Yasuda, Y., Kawamoto, H., Yagi, T. ... Shimizu, K. (2011). TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers. Molecular Medicine Reports, 4, 489-495. https://doi.org/10.3892/mmr.2011.449
MLA
Sonoyama, T., Sakai, A., Mita, Y., Yasuda, Y., Kawamoto, H., Yagi, T., Yoshioka, M., Mimura, T., Nakachi, K., Ouchida, M., Yamamoto, K., Shimizu, K."TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers". Molecular Medicine Reports 4.3 (2011): 489-495.
Chicago
Sonoyama, T., Sakai, A., Mita, Y., Yasuda, Y., Kawamoto, H., Yagi, T., Yoshioka, M., Mimura, T., Nakachi, K., Ouchida, M., Yamamoto, K., Shimizu, K."TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers". Molecular Medicine Reports 4, no. 3 (2011): 489-495. https://doi.org/10.3892/mmr.2011.449
Copy and paste a formatted citation
x
Spandidos Publications style
Sonoyama T, Sakai A, Mita Y, Yasuda Y, Kawamoto H, Yagi T, Yoshioka M, Mimura T, Nakachi K, Ouchida M, Ouchida M, et al: TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers. Mol Med Rep 4: 489-495, 2011.
APA
Sonoyama, T., Sakai, A., Mita, Y., Yasuda, Y., Kawamoto, H., Yagi, T. ... Shimizu, K. (2011). TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers. Molecular Medicine Reports, 4, 489-495. https://doi.org/10.3892/mmr.2011.449
MLA
Sonoyama, T., Sakai, A., Mita, Y., Yasuda, Y., Kawamoto, H., Yagi, T., Yoshioka, M., Mimura, T., Nakachi, K., Ouchida, M., Yamamoto, K., Shimizu, K."TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers". Molecular Medicine Reports 4.3 (2011): 489-495.
Chicago
Sonoyama, T., Sakai, A., Mita, Y., Yasuda, Y., Kawamoto, H., Yagi, T., Yoshioka, M., Mimura, T., Nakachi, K., Ouchida, M., Yamamoto, K., Shimizu, K."TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers". Molecular Medicine Reports 4, no. 3 (2011): 489-495. https://doi.org/10.3892/mmr.2011.449
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