TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers

  • Authors:
    • Takayuki Sonoyama
    • Akiko Sakai
    • Yuichiro Mita
    • Yukiko Yasuda
    • Hirofumi Kawamoto
    • Takahito Yagi
    • Masao Yoshioka
    • Tetsushige Mimura
    • Kei Nakachi
    • Mamoru Ouchida
    • Kazuhide Yamamoto
    • Kenji Shimizu
  • View Affiliations

  • Published online on: March 8, 2011     https://doi.org/10.3892/mmr.2011.449
  • Pages: 489-495
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Abstract

Tumor protein p53 (TP53) is the best-known tumor suppressor gene and plays a crucial role in carcinogenesis. The TP53 Arg 72 Pro polymorphism has been reported to be a risk factor for several types of cancer, but its association with pancreatic cancer has not been fully evaluated. Therefore, we investigated the effects of this polymorphism on pancreatic cancer in relation to smoking and drinking habits by examining the distribution of the SNP genotypes in 226 pancreatic cancer patients and 448 healthy controls. The frequencies of Arg/Arg, Arg/Pro and Pro/Pro were found to be 37, 49 and 15% in the pancreatic cancer cases and 44, 46 and 10% in the controls, respectively. Compared to the controls with the Arg/Arg genotype, cases with Pro/Pro homozygosity exhibited a significantly increased risk [adjusted odds ratio (OR)=1.70; 95% confidence interval (CI) 1.01-2.88]. In stratified studies, the association was particularly strong in males (OR=2.62; 95% CI 1.32-5.23), particularly in those smoking in excess of 20 pack-years and drinking in excess of 23 g ethanol/day (OR=5.02; 95% CI 1.12-22.51). We found that the TP53 Pro/Pro genotype compared to the Arg/Arg genotype had a profound effect on pancreatic cancer risk among males, particularly among heavy smokers and excessive alcohol drinkers.

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May-June 2011
Volume 4 Issue 3

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Spandidos Publications style
Sonoyama T, Sakai A, Mita Y, Yasuda Y, Kawamoto H, Yagi T, Yoshioka M, Mimura T, Nakachi K, Ouchida M, Ouchida M, et al: TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers. Mol Med Rep 4: 489-495, 2011
APA
Sonoyama, T., Sakai, A., Mita, Y., Yasuda, Y., Kawamoto, H., Yagi, T. ... Shimizu, K. (2011). TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers. Molecular Medicine Reports, 4, 489-495. https://doi.org/10.3892/mmr.2011.449
MLA
Sonoyama, T., Sakai, A., Mita, Y., Yasuda, Y., Kawamoto, H., Yagi, T., Yoshioka, M., Mimura, T., Nakachi, K., Ouchida, M., Yamamoto, K., Shimizu, K."TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers". Molecular Medicine Reports 4.3 (2011): 489-495.
Chicago
Sonoyama, T., Sakai, A., Mita, Y., Yasuda, Y., Kawamoto, H., Yagi, T., Yoshioka, M., Mimura, T., Nakachi, K., Ouchida, M., Yamamoto, K., Shimizu, K."TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers". Molecular Medicine Reports 4, no. 3 (2011): 489-495. https://doi.org/10.3892/mmr.2011.449