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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2011 Volume 4 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Effects of fenofibrate on Semaphorin 6B gene expression in rat skeletal muscle

  • Authors:
    • Hossam Murad
    • Fadia Kasies
    • Raed Azroony
    • Ghassan Alya
    • Ammar Madania

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Biology and Biotechnology and Division of Human Genetics, Atomic Energy Commission of Syria, 6091 Damascus, Syria, Department of Molecular Biology and Biotechnology and Division of Mammalian Biology, Atomic Energy Commission of Syria, 6091 Damascus, Syria, Department of Radiation Medicine, Biomedical Division, Atomic Energy Commission, Damascus, Syria
  • Pages: 575-580
    |
    Published online on: March 22, 2011
       https://doi.org/10.3892/mmr.2011.463
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Abstract

Semaphorin 6B is a member of the semaphorin family of signaling proteins, which is implicated in a variety of biological processes, such as axon guidance and muscle regeneration. PPARα is known to be a regulator of semaphorin 6B in human cancer cell lines. In this study, we examined the effect of fenofibrate as a PPARα activator on the expression of the Sema6B gene in rat skeletal muscle. A total of 18 rats were divided into two groups: one fed with standard chow (control group), and the other with fenofibrate chow (treatment group) for 4 weeks by gavage with 30 mg/kg per day. The expression of rSema6B mRNA was analyzed by qPCR. rSema6B protein content in rat skeletal muscle was measured by Western blotting. A significant down-regulation of rSema6B was observed at both the mRNA and protein levels. Using the ChIP assay, a putative PPARα binding region (PPRE) was identified in the rSema6B promoter. We conclude that the expression of Sema6B is down-regulated by fenofibarte in rat skeletal muscle.

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Copy and paste a formatted citation
Spandidos Publications style
Murad H, Kasies F, Azroony R, Alya G and Madania A: Effects of fenofibrate on Semaphorin 6B gene expression in rat skeletal muscle. Mol Med Rep 4: 575-580, 2011.
APA
Murad, H., Kasies, F., Azroony, R., Alya, G., & Madania, A. (2011). Effects of fenofibrate on Semaphorin 6B gene expression in rat skeletal muscle. Molecular Medicine Reports, 4, 575-580. https://doi.org/10.3892/mmr.2011.463
MLA
Murad, H., Kasies, F., Azroony, R., Alya, G., Madania, A."Effects of fenofibrate on Semaphorin 6B gene expression in rat skeletal muscle". Molecular Medicine Reports 4.3 (2011): 575-580.
Chicago
Murad, H., Kasies, F., Azroony, R., Alya, G., Madania, A."Effects of fenofibrate on Semaphorin 6B gene expression in rat skeletal muscle". Molecular Medicine Reports 4, no. 3 (2011): 575-580. https://doi.org/10.3892/mmr.2011.463
Copy and paste a formatted citation
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Spandidos Publications style
Murad H, Kasies F, Azroony R, Alya G and Madania A: Effects of fenofibrate on Semaphorin 6B gene expression in rat skeletal muscle. Mol Med Rep 4: 575-580, 2011.
APA
Murad, H., Kasies, F., Azroony, R., Alya, G., & Madania, A. (2011). Effects of fenofibrate on Semaphorin 6B gene expression in rat skeletal muscle. Molecular Medicine Reports, 4, 575-580. https://doi.org/10.3892/mmr.2011.463
MLA
Murad, H., Kasies, F., Azroony, R., Alya, G., Madania, A."Effects of fenofibrate on Semaphorin 6B gene expression in rat skeletal muscle". Molecular Medicine Reports 4.3 (2011): 575-580.
Chicago
Murad, H., Kasies, F., Azroony, R., Alya, G., Madania, A."Effects of fenofibrate on Semaphorin 6B gene expression in rat skeletal muscle". Molecular Medicine Reports 4, no. 3 (2011): 575-580. https://doi.org/10.3892/mmr.2011.463
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