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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2011 Volume 4 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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An International Open Access Journal Devoted to General Medicine.

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Article

Identification of HZF1 as a novel target gene of the MEF2 transcription factor

  • Authors:
    • Xi Liu
    • En-Ze Jin
    • Ji-Xin Zhi
    • Xue-Qi Li

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
  • Pages: 465-469
    |
    Published online on: March 22, 2011
       https://doi.org/10.3892/mmr.2011.465
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Abstract

The MADS box-containing transcription factors MEF2A-D regulate the expression of most skeletal and cardiac muscle structural genes. Recently, a zinc finger protein called HZF1 was identified as a transcription factor, and found to be highly expressed in cardiac muscle. By screening the transcription regulatory region of HZF1, we found that myocyte enhancer factor 2 (MEF2) potentially recognizes and binds the regulatory region of the HZF1 gene. We also found that the knockdown of MEF2A endogenous expression in human aortic smooth muscle cells decreases the expression of HZF1, while the enforced expression of MEF2A in turn promotes the expression of HZF1. Furthermore, we employed the luciferase reporter system and chromatin immunoprecipitation (ChIP) to demonstrate that MEF2A does in fact bind the regulatory region of HZF1, which suggests that HZF1 is the direct target of MEF2A. Based on the fact that MEF2 proteins function as essential regulators of cardiac development and as important pathological factors for certain cardiac diseases, our finding that MEF2 positively regulates the expression of HZF1 may contribute to further research investigating the role of the zinc finger protein HZF1 in cardiac development and disease.

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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Jin E, Zhi J and Li X: Identification of HZF1 as a novel target gene of the MEF2 transcription factor. Mol Med Rep 4: 465-469, 2011.
APA
Liu, X., Jin, E., Zhi, J., & Li, X. (2011). Identification of HZF1 as a novel target gene of the MEF2 transcription factor. Molecular Medicine Reports, 4, 465-469. https://doi.org/10.3892/mmr.2011.465
MLA
Liu, X., Jin, E., Zhi, J., Li, X."Identification of HZF1 as a novel target gene of the MEF2 transcription factor". Molecular Medicine Reports 4.3 (2011): 465-469.
Chicago
Liu, X., Jin, E., Zhi, J., Li, X."Identification of HZF1 as a novel target gene of the MEF2 transcription factor". Molecular Medicine Reports 4, no. 3 (2011): 465-469. https://doi.org/10.3892/mmr.2011.465
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Jin E, Zhi J and Li X: Identification of HZF1 as a novel target gene of the MEF2 transcription factor. Mol Med Rep 4: 465-469, 2011.
APA
Liu, X., Jin, E., Zhi, J., & Li, X. (2011). Identification of HZF1 as a novel target gene of the MEF2 transcription factor. Molecular Medicine Reports, 4, 465-469. https://doi.org/10.3892/mmr.2011.465
MLA
Liu, X., Jin, E., Zhi, J., Li, X."Identification of HZF1 as a novel target gene of the MEF2 transcription factor". Molecular Medicine Reports 4.3 (2011): 465-469.
Chicago
Liu, X., Jin, E., Zhi, J., Li, X."Identification of HZF1 as a novel target gene of the MEF2 transcription factor". Molecular Medicine Reports 4, no. 3 (2011): 465-469. https://doi.org/10.3892/mmr.2011.465
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