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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2011 Volume 4 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Molecular and clinical characteristics of Hemoglobin Ottawa detected in a Chinese population

  • Authors:
    • Yue Huang
    • Min Lin
    • Chun-Ping Lin
    • Jiao-Ren Wu
    • Luo-Han Zheng
    • Li-Ye Yang

  • View Affiliations / Copyright

    Affiliations: Department of Central Laboratory, Chaozhou Central Hospital, Chaozhou, Guangdong 521021, P.R. China
  • Pages: 581-583
    |
    Published online on: March 22, 2011
       https://doi.org/10.3892/mmr.2011.467
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Abstract

Hemoglobin (Hb) Ottawa [α15 (A13) Gly→Arg], also known as Hb Siam, was first described in an 82-year-old Canadian in 1974. The same year, a second case was reported in a 28-year-old Chinese male living in Thailand. A third case was found in 1986 in a Chinese female living in the Hubei province of China. Since then, there have been no reports of Hb Ottawa in mainland China in the English literature. Hb Ottawa results from a GGT→CGT mutation in codon 15 of the α1 or α2-globin gene. Hb Ottawa carriers do not present any clinical symptoms or hematological changes, and are often diagnosed during a health examination and thalassemia screening. In a hemoglobin survey of 9745 students in Chaozhou, Guangdong, China, we identified four cases of Hb Ottawa in a thalassemia screening by Hb electrophoresis, and confirmed it to be the result of a GGT→CGT mutation in codon 15 of the α2-globin gene by DNA sequence analysis.

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Copy and paste a formatted citation
Spandidos Publications style
Huang Y, Lin M, Lin C, Wu J, Zheng L and Yang L: Molecular and clinical characteristics of Hemoglobin Ottawa detected in a Chinese population. Mol Med Rep 4: 581-583, 2011.
APA
Huang, Y., Lin, M., Lin, C., Wu, J., Zheng, L., & Yang, L. (2011). Molecular and clinical characteristics of Hemoglobin Ottawa detected in a Chinese population. Molecular Medicine Reports, 4, 581-583. https://doi.org/10.3892/mmr.2011.467
MLA
Huang, Y., Lin, M., Lin, C., Wu, J., Zheng, L., Yang, L."Molecular and clinical characteristics of Hemoglobin Ottawa detected in a Chinese population". Molecular Medicine Reports 4.3 (2011): 581-583.
Chicago
Huang, Y., Lin, M., Lin, C., Wu, J., Zheng, L., Yang, L."Molecular and clinical characteristics of Hemoglobin Ottawa detected in a Chinese population". Molecular Medicine Reports 4, no. 3 (2011): 581-583. https://doi.org/10.3892/mmr.2011.467
Copy and paste a formatted citation
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Spandidos Publications style
Huang Y, Lin M, Lin C, Wu J, Zheng L and Yang L: Molecular and clinical characteristics of Hemoglobin Ottawa detected in a Chinese population. Mol Med Rep 4: 581-583, 2011.
APA
Huang, Y., Lin, M., Lin, C., Wu, J., Zheng, L., & Yang, L. (2011). Molecular and clinical characteristics of Hemoglobin Ottawa detected in a Chinese population. Molecular Medicine Reports, 4, 581-583. https://doi.org/10.3892/mmr.2011.467
MLA
Huang, Y., Lin, M., Lin, C., Wu, J., Zheng, L., Yang, L."Molecular and clinical characteristics of Hemoglobin Ottawa detected in a Chinese population". Molecular Medicine Reports 4.3 (2011): 581-583.
Chicago
Huang, Y., Lin, M., Lin, C., Wu, J., Zheng, L., Yang, L."Molecular and clinical characteristics of Hemoglobin Ottawa detected in a Chinese population". Molecular Medicine Reports 4, no. 3 (2011): 581-583. https://doi.org/10.3892/mmr.2011.467
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