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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2011 Volume 4 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September-October 2011 Volume 4 Issue 5

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Article

Differential expression of Mart-1 in human uveal melanoma cells

  • Authors:
    • Jing Wang
    • Renbing Jia
    • Yuting Yao
    • Biyun Cun
    • Xiaolin  Huang
    • Ping Gu
    • Shengfang Ge
    • Xianqun Fan

  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai 200011, P.R. China
  • Pages: 799-803
    |
    Published online on: June 7, 2011
       https://doi.org/10.3892/mmr.2011.504
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Abstract

Uveal melanoma (UM) is one of the most common primary intraocular malignant tumors in adults. Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, has been widely studied as a marker recognized by cytotoxicity T lymphocytes. Mart-1 is considered to play a critical role in the immunotherapy for melanoma. Additionally, as a biomarker, Mart-1 is often used with other tumor-associated antigens for antidiastole in cutaneous melanoma (CM), uveal melanoma (UM) and nevus. In this study, the differential expression of Mart-1 was investigated in four human UM cells (SP6.5, VUP, OCM-1 and OM431) on three levels of analysis: messenger ribonucleic acid (mRNA), protein and, eventually, morphology. The results revealed that SP6.5 cells had high Mart-1 protein expression while VUP cells had almost none. OCM-1 and OM431 cells produced less Mart-1 than SP6.5 cells according to Western blot analysis, although OM431 cells had the highest expression of Mart-1 mRNA according to real-time PCR. The results indicate the potential use of Mart-1 in the development of therapy for UM.

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Jia R, Yao Y, Cun B, Huang X, Gu P, Ge S and Fan X: Differential expression of Mart-1 in human uveal melanoma cells. Mol Med Rep 4: 799-803, 2011.
APA
Wang, J., Jia, R., Yao, Y., Cun, B., Huang, X., Gu, P. ... Fan, X. (2011). Differential expression of Mart-1 in human uveal melanoma cells. Molecular Medicine Reports, 4, 799-803. https://doi.org/10.3892/mmr.2011.504
MLA
Wang, J., Jia, R., Yao, Y., Cun, B., Huang, X., Gu, P., Ge, S., Fan, X."Differential expression of Mart-1 in human uveal melanoma cells". Molecular Medicine Reports 4.5 (2011): 799-803.
Chicago
Wang, J., Jia, R., Yao, Y., Cun, B., Huang, X., Gu, P., Ge, S., Fan, X."Differential expression of Mart-1 in human uveal melanoma cells". Molecular Medicine Reports 4, no. 5 (2011): 799-803. https://doi.org/10.3892/mmr.2011.504
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Jia R, Yao Y, Cun B, Huang X, Gu P, Ge S and Fan X: Differential expression of Mart-1 in human uveal melanoma cells. Mol Med Rep 4: 799-803, 2011.
APA
Wang, J., Jia, R., Yao, Y., Cun, B., Huang, X., Gu, P. ... Fan, X. (2011). Differential expression of Mart-1 in human uveal melanoma cells. Molecular Medicine Reports, 4, 799-803. https://doi.org/10.3892/mmr.2011.504
MLA
Wang, J., Jia, R., Yao, Y., Cun, B., Huang, X., Gu, P., Ge, S., Fan, X."Differential expression of Mart-1 in human uveal melanoma cells". Molecular Medicine Reports 4.5 (2011): 799-803.
Chicago
Wang, J., Jia, R., Yao, Y., Cun, B., Huang, X., Gu, P., Ge, S., Fan, X."Differential expression of Mart-1 in human uveal melanoma cells". Molecular Medicine Reports 4, no. 5 (2011): 799-803. https://doi.org/10.3892/mmr.2011.504
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