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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2011 Volume 4 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus

  • Authors:
    • Shen-Long Howng
    • An-Kuo Chou
    • Ching-Chih Lin
    • Zhi-Ann Lin
    • Chih-Jen Wang
    • Joon-Khim Loh
    • Ann-Shung Lieu
    • Jeng-Hsien Yen
    • Chu-I Lee
    • Yi-Ren Hong

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C., Department of Biochemistry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C., Department of Biochemistry, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan, R.O.C., Department of Medical Laboratory Science and Biotechnology, Fooyin University, Ta-Liao Hsiang, Kaohsiung Hsien 83102, Taiwan, R.O.C.
  • Pages: 825-830
    |
    Published online on: June 7, 2011
       https://doi.org/10.3892/mmr.2011.505
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Abstract

Centrosomes are organelles involved in the organization of the mitotic spindle and may also be the targets of autoantibodies in autoimmune diseases. Human Ninein (hNinein) is a centrosomal autoantigen that is identified by autoimmune patient sera. However, none of the hNinein-specific fragments recognized by the autoantibodies in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) sera have been thoroughly characterized. We thus attempted to identify the fine specificity within the hNinein protein. In this study, four recombinant proteins in two isoforms of hNinein were used as autoantigens along with immunoassays as a molecular tool to investigate the prevalence of hNinein autoreactivity and its specificity in 22 RA and 32 SLE autoimmune disease sera. The data indicated a 50% higher prevalence of isoform 4 hNinein N-terminal autoantibodies in RA sera, whereas 22% of SLE patients were autoreactive to the N-terminal of isoform 4 hNinein compared to only a small percentage of autoreactive normal sera (5%). These results showed that autoepitopes on autoantigen hNinein are restricted to the N-terminal region and that a more significant proportion of RA patients exhibited centrosome reactivity.

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Copy and paste a formatted citation
Spandidos Publications style
Howng S, Chou A, Lin C, Lin Z, Wang C, Loh J, Lieu A, Yen J, Lee C, Hong Y, Hong Y, et al: Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus. Mol Med Rep 4: 825-830, 2011.
APA
Howng, S., Chou, A., Lin, C., Lin, Z., Wang, C., Loh, J. ... Hong, Y. (2011). Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus. Molecular Medicine Reports, 4, 825-830. https://doi.org/10.3892/mmr.2011.505
MLA
Howng, S., Chou, A., Lin, C., Lin, Z., Wang, C., Loh, J., Lieu, A., Yen, J., Lee, C., Hong, Y."Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus". Molecular Medicine Reports 4.5 (2011): 825-830.
Chicago
Howng, S., Chou, A., Lin, C., Lin, Z., Wang, C., Loh, J., Lieu, A., Yen, J., Lee, C., Hong, Y."Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus". Molecular Medicine Reports 4, no. 5 (2011): 825-830. https://doi.org/10.3892/mmr.2011.505
Copy and paste a formatted citation
x
Spandidos Publications style
Howng S, Chou A, Lin C, Lin Z, Wang C, Loh J, Lieu A, Yen J, Lee C, Hong Y, Hong Y, et al: Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus. Mol Med Rep 4: 825-830, 2011.
APA
Howng, S., Chou, A., Lin, C., Lin, Z., Wang, C., Loh, J. ... Hong, Y. (2011). Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus. Molecular Medicine Reports, 4, 825-830. https://doi.org/10.3892/mmr.2011.505
MLA
Howng, S., Chou, A., Lin, C., Lin, Z., Wang, C., Loh, J., Lieu, A., Yen, J., Lee, C., Hong, Y."Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus". Molecular Medicine Reports 4.5 (2011): 825-830.
Chicago
Howng, S., Chou, A., Lin, C., Lin, Z., Wang, C., Loh, J., Lieu, A., Yen, J., Lee, C., Hong, Y."Autoimmunity against hNinein, a human centrosomal protein, in patients with rheumatoid arthritis and systemic lupus erythematosus". Molecular Medicine Reports 4, no. 5 (2011): 825-830. https://doi.org/10.3892/mmr.2011.505
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