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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2011 Volume 4 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Proteomic analysis identifies nuclear protein effectors in PKC-δ signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells

  • Authors:
    • Fang Sun
    • Bo Zhou
    • Xuebo Lin
    • Lian Duan

  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
  • Pages: 865-872
    |
    Published online on: July 4, 2011
       https://doi.org/10.3892/mmr.2011.531
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Abstract

Although experimental animal and clinical trials have suggested that additional mechanisms other than protein kinase C (PKC)-β activation are involved in the vascular pathology of diabetic complications, current knowledge on the role of PKC-δ is incomplete and inconclusive. Human umbilical vein endothelial cells (HUVECs) were cultured in both high and normal glucose conditions and infected with recombinant adenovirus to overexpress PKC-δ. PKC-δ expression was also down-regulated using the PKC-δ inhibitor, rottlerin. Using flow cytometric analysis, we showed that PKC-δ is activated and translocates to the nucleus under high glucose conditions. Augmented cell apoptosis and cell cycle arrest were observed in a PKC-δ-dependent manner in the HUVECs. Furthermore, proteomic analyses identified 51 high glucose-induced and PKC-δ-associated proteins, and subsequent matrix-assisted laser desorption/ionization time of flight mass spectrometry analysis uncovered a total of 37 unique proteins. The majority of identified proteins were previously unknown targets of PKC-δ signaling and were involved in the regulation of the cell cycle and apoptosis, tumor suppression, transcription, stress and signal transduction within the nucleus. Our data show that PKC-δ is an important mediator of cell apoptosis and cell cycle arrest in HUVECs under high glucose stress.

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Copy and paste a formatted citation
Spandidos Publications style
Sun F, Zhou B, Lin X and Duan L: Proteomic analysis identifies nuclear protein effectors in PKC-δ signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells. Mol Med Rep 4: 865-872, 2011.
APA
Sun, F., Zhou, B., Lin, X., & Duan, L. (2011). Proteomic analysis identifies nuclear protein effectors in PKC-δ signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells. Molecular Medicine Reports, 4, 865-872. https://doi.org/10.3892/mmr.2011.531
MLA
Sun, F., Zhou, B., Lin, X., Duan, L."Proteomic analysis identifies nuclear protein effectors in PKC-δ signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells". Molecular Medicine Reports 4.5 (2011): 865-872.
Chicago
Sun, F., Zhou, B., Lin, X., Duan, L."Proteomic analysis identifies nuclear protein effectors in PKC-δ signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells". Molecular Medicine Reports 4, no. 5 (2011): 865-872. https://doi.org/10.3892/mmr.2011.531
Copy and paste a formatted citation
x
Spandidos Publications style
Sun F, Zhou B, Lin X and Duan L: Proteomic analysis identifies nuclear protein effectors in PKC-δ signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells. Mol Med Rep 4: 865-872, 2011.
APA
Sun, F., Zhou, B., Lin, X., & Duan, L. (2011). Proteomic analysis identifies nuclear protein effectors in PKC-δ signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells. Molecular Medicine Reports, 4, 865-872. https://doi.org/10.3892/mmr.2011.531
MLA
Sun, F., Zhou, B., Lin, X., Duan, L."Proteomic analysis identifies nuclear protein effectors in PKC-δ signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells". Molecular Medicine Reports 4.5 (2011): 865-872.
Chicago
Sun, F., Zhou, B., Lin, X., Duan, L."Proteomic analysis identifies nuclear protein effectors in PKC-δ signaling under high glucose-induced apoptosis in human umbilical vein endothelial cells". Molecular Medicine Reports 4, no. 5 (2011): 865-872. https://doi.org/10.3892/mmr.2011.531
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