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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January 2012 Volume 5 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo

  • Authors:
    • Xin Wang
    • Fei Jiao
    • Qin-Wen Wang
    • Juan Wang
    • Ke Yang
    • Rong-Rong Hu
    • Han-Chen Liu
    • Hong-Yang Wang
    • Yi-Shan Wang

  • View Affiliations / Copyright

    Affiliations: The Center of Non-Traumatic Treatment and Diagnosis of Tumor, Binzhou Medical College Affiliated The PLA 107 Hospital, Yantai, Shandong 264002, P.R. China, Department of Biochemistry and Molecular Biology, Binzhou Medical College, Yantai, Shandong 264003, P.R. China, Department of Biotechnology, Binzhou Medical College, Yantai, Shandong 264003, P.R. China, Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, P.R. China
  • Pages: 66-72
    |
    Published online on: September 13, 2011
       https://doi.org/10.3892/mmr.2011.588
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Abstract

There is mounting evidence that garlic extracts possess significant anticancer actions. However, no studies have been reported on the effects of aged black garlic extracts (ABGE) on gastric cancer in vitro or in vivo. To examine the potential action of ABGE against gastric cancer, the present study evaluated its effect on the inhibition of cell proliferation and induction of apoptosis in SGC-7901 human gastric cancer cells. Additionally, we performed an in vivo study by inoculating the murine foregastric carcinoma cell line in Kunming mice and treating them with various doses of ABGE (0, 200, 400 and 800 mg/kg, intraperitoneally) for 2 weeks. Dose-dependent apoptosis was detected in ABGE-treated cells in in vitro studies. In tumor-bearing mice, significant antitumor effects of ABGE were observed, such as growth inhibition of inoculated tumors. Further investigation of serum superoxide dismutases, glutathione peroxidase, interleukin-2 and the increased indices of spleen and thymus indicated that the anticancer action of ABGE may be partly due to its antioxidant and immuno­modulative effects.

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Jiao F, Wang Q, Wang J, Yang K, Hu R, Liu H, Wang H and Wang Y: Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo. Mol Med Rep 5: 66-72, 2012.
APA
Wang, X., Jiao, F., Wang, Q., Wang, J., Yang, K., Hu, R. ... Wang, Y. (2012). Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo. Molecular Medicine Reports, 5, 66-72. https://doi.org/10.3892/mmr.2011.588
MLA
Wang, X., Jiao, F., Wang, Q., Wang, J., Yang, K., Hu, R., Liu, H., Wang, H., Wang, Y."Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo". Molecular Medicine Reports 5.1 (2012): 66-72.
Chicago
Wang, X., Jiao, F., Wang, Q., Wang, J., Yang, K., Hu, R., Liu, H., Wang, H., Wang, Y."Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo". Molecular Medicine Reports 5, no. 1 (2012): 66-72. https://doi.org/10.3892/mmr.2011.588
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Jiao F, Wang Q, Wang J, Yang K, Hu R, Liu H, Wang H and Wang Y: Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo. Mol Med Rep 5: 66-72, 2012.
APA
Wang, X., Jiao, F., Wang, Q., Wang, J., Yang, K., Hu, R. ... Wang, Y. (2012). Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo. Molecular Medicine Reports, 5, 66-72. https://doi.org/10.3892/mmr.2011.588
MLA
Wang, X., Jiao, F., Wang, Q., Wang, J., Yang, K., Hu, R., Liu, H., Wang, H., Wang, Y."Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo". Molecular Medicine Reports 5.1 (2012): 66-72.
Chicago
Wang, X., Jiao, F., Wang, Q., Wang, J., Yang, K., Hu, R., Liu, H., Wang, H., Wang, Y."Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo". Molecular Medicine Reports 5, no. 1 (2012): 66-72. https://doi.org/10.3892/mmr.2011.588
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