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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January 2012 Volume 5 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet

  • Authors:
    • Hironori Nakagami
    • Munehisa Shimamura
    • Takashi Miyake
    • Takashi Shimosato
    • Noriko Minobe
    • Toshinori Moritani
    • Mariana Kiomy Osako
    • Futoshi Nakagami
    • Hiroshi Koriyama
    • Mariko Kyutoku
    • Hideo Shimizu
    • Tomohiro Katsuya
    • Ryuichi Morishita
  • View Affiliations / Copyright

    Affiliations: Division of Vascular Medicine and Epigenetics, Osaka University United Graduate School of Child Development, Osaka 565-0871, Japan, Research Department, Nissei Bilis Co. Ltd., Koka, Shiga 528-0052, Japan, Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan, Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
  • Pages: 37-40
    |
    Published online on: September 21, 2011
       https://doi.org/10.3892/mmr.2011.594
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Abstract

Recent reports have shown that nifedipine, a calcium channel blocker, increases peroxisome proliferator-activated receptor-γ (PPARγ) activity. Since PPARγ agonists, such as pioglitazone and rosiglitazone, are effective in reducing non-alcoholic steatohepatitis (NASH) and cirrhosis in animal models, we examined the protective effects of nifedipine, as compared with bezafibrate, a PPARα agonist, in a NASH model induced by an L-methionine- and choline-deficient (MCD) diet. An MCD diet for 20 weeks changed the color of the rat liver to yellow with an irregular surface, whereas the color of the liver in both the bezafibrate and nifedipine treatment groups was markedly changed to yellow-brown with a smooth surface. Furthermore, nifedipine, as well as bezafibrate, significantly prevented liver fibrosis induced by an MCD diet, as assessed by Masson's trichrome staining, accompanied by a significant decrease in serum AST. Overall, nifedipine treatment resulted in an improvement in NASH, similar to bezafibrate, in a rat model. In hypertensive patients with metabolic syndrome, nifedipine may provide additional benefits, beyond its blood pressure-lowering effects, to prevent NASH and fatty liver disease.

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Copy and paste a formatted citation
Spandidos Publications style
Nakagami H, Shimamura M, Miyake T, Shimosato T, Minobe N, Moritani T, Kiomy Osako M, Nakagami F, Koriyama H, Kyutoku M, Kyutoku M, et al: Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet. Mol Med Rep 5: 37-40, 2012.
APA
Nakagami, H., Shimamura, M., Miyake, T., Shimosato, T., Minobe, N., Moritani, T. ... Morishita, R. (2012). Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet. Molecular Medicine Reports, 5, 37-40. https://doi.org/10.3892/mmr.2011.594
MLA
Nakagami, H., Shimamura, M., Miyake, T., Shimosato, T., Minobe, N., Moritani, T., Kiomy Osako, M., Nakagami, F., Koriyama, H., Kyutoku, M., Shimizu, H., Katsuya, T., Morishita, R."Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet". Molecular Medicine Reports 5.1 (2012): 37-40.
Chicago
Nakagami, H., Shimamura, M., Miyake, T., Shimosato, T., Minobe, N., Moritani, T., Kiomy Osako, M., Nakagami, F., Koriyama, H., Kyutoku, M., Shimizu, H., Katsuya, T., Morishita, R."Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet". Molecular Medicine Reports 5, no. 1 (2012): 37-40. https://doi.org/10.3892/mmr.2011.594
Copy and paste a formatted citation
x
Spandidos Publications style
Nakagami H, Shimamura M, Miyake T, Shimosato T, Minobe N, Moritani T, Kiomy Osako M, Nakagami F, Koriyama H, Kyutoku M, Kyutoku M, et al: Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet. Mol Med Rep 5: 37-40, 2012.
APA
Nakagami, H., Shimamura, M., Miyake, T., Shimosato, T., Minobe, N., Moritani, T. ... Morishita, R. (2012). Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet. Molecular Medicine Reports, 5, 37-40. https://doi.org/10.3892/mmr.2011.594
MLA
Nakagami, H., Shimamura, M., Miyake, T., Shimosato, T., Minobe, N., Moritani, T., Kiomy Osako, M., Nakagami, F., Koriyama, H., Kyutoku, M., Shimizu, H., Katsuya, T., Morishita, R."Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet". Molecular Medicine Reports 5.1 (2012): 37-40.
Chicago
Nakagami, H., Shimamura, M., Miyake, T., Shimosato, T., Minobe, N., Moritani, T., Kiomy Osako, M., Nakagami, F., Koriyama, H., Kyutoku, M., Shimizu, H., Katsuya, T., Morishita, R."Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet". Molecular Medicine Reports 5, no. 1 (2012): 37-40. https://doi.org/10.3892/mmr.2011.594
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