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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January 2012 Volume 5 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2012 Volume 5 Issue 1

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Article

The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer

  • Authors:
    • Yoon Jae Kim
    • Soo Bin Park
    • Jeong Youp Park
    • Seung Woo Park
    • Jae Bock Chung
    • Si Young Song
    • Seungmin Bang

  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Department of Internal Medicine, Gachon University of Medicine and Science, Gil Medical Center, Incheon, Republic of Korea, Division of Gastro­enterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea
  • Pages: 12-16
    |
    Published online on: September 23, 2011
       https://doi.org/10.3892/mmr.2011.598
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Abstract

Sonic hedgehog (SHh) signaling is essential for normal development of the human gastrointestinal (GI) tract and is reported to be aberrantly activated in GI cancers. However, the association between SHh signaling and extrahepatic biliary tract cancer is not clearly understood. In this study, we evaluated the activities of SHh family proteins and their downstream signals in extrahepatic biliary tract cancer. The activity of the SHh pathway was analyzed in established human extrahepatic biliary tract cell lines and human cancer tissues using RT-PCR and immunohistochemistry. We also evaluated the effects of suppressing the SHh pathway with cyclopamine and siRNA. The SHh, Smo and Gli-1 genes were overexpressed in extrahepatic biliary tract cancer cell lines and six extrahepatic biliary tract cancer tissues compared to the levels in normal biliary tract tissues. The degrees of SHh and Gli-1 expression were independent of tumor stage and cancer cell differentiation. SHh pathway suppression with cyclopamine or siRNA inhibited proliferation of extrahepatic biliary tract cancer cell lines. In conclusion, the SHh pathway is highly activated in extrahepatic biliary tract cancer and is a potential anticancer drug target.

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Copy and paste a formatted citation
Spandidos Publications style
Kim Y, Park S, Park J, Park S, Chung J, Song S and Bang S: The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer. Mol Med Rep 5: 12-16, 2012.
APA
Kim, Y., Park, S., Park, J., Park, S., Chung, J., Song, S., & Bang, S. (2012). The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer. Molecular Medicine Reports, 5, 12-16. https://doi.org/10.3892/mmr.2011.598
MLA
Kim, Y., Park, S., Park, J., Park, S., Chung, J., Song, S., Bang, S."The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer". Molecular Medicine Reports 5.1 (2012): 12-16.
Chicago
Kim, Y., Park, S., Park, J., Park, S., Chung, J., Song, S., Bang, S."The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer". Molecular Medicine Reports 5, no. 1 (2012): 12-16. https://doi.org/10.3892/mmr.2011.598
Copy and paste a formatted citation
x
Spandidos Publications style
Kim Y, Park S, Park J, Park S, Chung J, Song S and Bang S: The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer. Mol Med Rep 5: 12-16, 2012.
APA
Kim, Y., Park, S., Park, J., Park, S., Chung, J., Song, S., & Bang, S. (2012). The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer. Molecular Medicine Reports, 5, 12-16. https://doi.org/10.3892/mmr.2011.598
MLA
Kim, Y., Park, S., Park, J., Park, S., Chung, J., Song, S., Bang, S."The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer". Molecular Medicine Reports 5.1 (2012): 12-16.
Chicago
Kim, Y., Park, S., Park, J., Park, S., Chung, J., Song, S., Bang, S."The sonic hedgehog pathway as a treatment target for extrahepatic biliary tract cancer". Molecular Medicine Reports 5, no. 1 (2012): 12-16. https://doi.org/10.3892/mmr.2011.598
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