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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January 2012 Volume 5 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Tiam1, overexpressed in most malignancies, is a novel tumor biomarker

  • Authors:
    • Bin Chen
    • Yi Ding
    • Feiye Liu
    • Jian Ruan
    • Jian Guan
    • Jing Huang
    • Xianghua Ye
    • Shuang Wang
    • Gong Zhang
    • Xiangmei Zhang
    • Zhao Liang
    • Rongcheng Luo
    • Longhua Chen

  • View Affiliations / Copyright

    Affiliations: General Hospital of Guangzhou Military Command of PLA, Guangzhou, Guangdong 510515, P.R. China, Department of Radiotherapy, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Cancer Research Institute, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
  • Pages: 48-53
    |
    Published online on: October 3, 2011
       https://doi.org/10.3892/mmr.2011.612
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Abstract

T lymphoma invasion and metastasis 1 (Tiam1) is a guanine nucleotide exchange factor (GNEF) family member, and is considered to be involved in many important cellular processes and oncogenesis. In this study, we investigated Tiam1 expression differences between normal tissue and malignant tissue using tissue microarray (TMA), and further studied the Tiam1 mRNA and protein level in 9 hepatoma lines. Forty-nine tumor tissue and 47 normal tissue samples were detected via TMA by immunohistochemistry with polyclonal antibody. Tiam1 expression in 9 human hepatoma cell lines, namely Huh-7, HepG2, Hep3B, SMMC-7721, QGy-7701, QGy-7703, BEL-7402, BEL-7404 and BEL-7405, and 1 normal primary human hepatocyte, HL-7702, was compared by means of fluorescence quantitative PCR, immunocytochemistry assay and Western blotting. We found that Tiam1 was significantly expressed in various malignancies. Tiam1 mRNA and protein levels were significantly elevated in the 9 human hepatoma cell lines compared to the normal primary human hepatocyte. Our results suggest that Tiam1 overexpression in malignant neoplasms could be a novel effective supplementary biomarker for tumors, including hepatocellular carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Chen B, Ding Y, Liu F, Ruan J, Guan J, Huang J, Ye X, Wang S, Zhang G, Zhang X, Zhang X, et al: Tiam1, overexpressed in most malignancies, is a novel tumor biomarker. Mol Med Rep 5: 48-53, 2012.
APA
Chen, B., Ding, Y., Liu, F., Ruan, J., Guan, J., Huang, J. ... Chen, L. (2012). Tiam1, overexpressed in most malignancies, is a novel tumor biomarker. Molecular Medicine Reports, 5, 48-53. https://doi.org/10.3892/mmr.2011.612
MLA
Chen, B., Ding, Y., Liu, F., Ruan, J., Guan, J., Huang, J., Ye, X., Wang, S., Zhang, G., Zhang, X., Liang, Z., Luo, R., Chen, L."Tiam1, overexpressed in most malignancies, is a novel tumor biomarker". Molecular Medicine Reports 5.1 (2012): 48-53.
Chicago
Chen, B., Ding, Y., Liu, F., Ruan, J., Guan, J., Huang, J., Ye, X., Wang, S., Zhang, G., Zhang, X., Liang, Z., Luo, R., Chen, L."Tiam1, overexpressed in most malignancies, is a novel tumor biomarker". Molecular Medicine Reports 5, no. 1 (2012): 48-53. https://doi.org/10.3892/mmr.2011.612
Copy and paste a formatted citation
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Spandidos Publications style
Chen B, Ding Y, Liu F, Ruan J, Guan J, Huang J, Ye X, Wang S, Zhang G, Zhang X, Zhang X, et al: Tiam1, overexpressed in most malignancies, is a novel tumor biomarker. Mol Med Rep 5: 48-53, 2012.
APA
Chen, B., Ding, Y., Liu, F., Ruan, J., Guan, J., Huang, J. ... Chen, L. (2012). Tiam1, overexpressed in most malignancies, is a novel tumor biomarker. Molecular Medicine Reports, 5, 48-53. https://doi.org/10.3892/mmr.2011.612
MLA
Chen, B., Ding, Y., Liu, F., Ruan, J., Guan, J., Huang, J., Ye, X., Wang, S., Zhang, G., Zhang, X., Liang, Z., Luo, R., Chen, L."Tiam1, overexpressed in most malignancies, is a novel tumor biomarker". Molecular Medicine Reports 5.1 (2012): 48-53.
Chicago
Chen, B., Ding, Y., Liu, F., Ruan, J., Guan, J., Huang, J., Ye, X., Wang, S., Zhang, G., Zhang, X., Liang, Z., Luo, R., Chen, L."Tiam1, overexpressed in most malignancies, is a novel tumor biomarker". Molecular Medicine Reports 5, no. 1 (2012): 48-53. https://doi.org/10.3892/mmr.2011.612
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