Polymorphism of the inosine triphosphate pyrophosphatase gene predicts ribavirin-induced anemia in chronic hepatitis C patients

  • Authors:
    • Takashi Nishimura
    • Rie Osaki
    • Makoto Shioya
    • Hirotsugu Imaeda
    • Tomoki Aomatsu
    • Takayuki Takeuchi
    • Yoshiaki Okumura
    • Yoshihide Fujiyama
    • Akira Andoh
  • View Affiliations

  • Published online on: November 2, 2011     https://doi.org/10.3892/mmr.2011.659
  • Pages:517-520
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Abstract

Ribavirin (RBV)-induced anemia is a serious side effect of pegylated interferon (PEG-IFN) plus RBV therapy which is the standard care most effective for hepatitis C virus (HCV) infection. In the present study, we investigated the association of inosine triphosphate pyrophosphatase (ITPA) genotypes with RBV-induced hemoglobin (Hb) reduction in HCV patients treated with PEG-IFN/RBV therapy. The genotypes of the ITPA rs1127354 single nucleotide polymorphism were determined in 179 patients with HCV infection. Among them, 52 patients were treated with PEG-IFN/RBV. The frequency of the ITPA major allele (CC) was 76.3% and that of the minor allele (CA and AA) was 23.7%. A rapid decrease in Hb levels during the initial 4 weeks was observed in patients with the ITPA major allele (CC), but not in patients with the ITPA minor allele (C/A and AA). Hb levels at 4 weeks were significantly lower in patients with the ITPA major allele than the levels in patients with the minor allele. Out of the 41 patients, 6 (14.6%) with ITPA major allele had Hb levels <10 g/dl and 11 patients (26.8%) had a decline in Hb of >3 g/dl. None of the patients with the ITPA minor allele had such data. There were no significant differences in virological responses of HCV-RNA between patients with the ITPA major allele and those with the minor allele. In conclusion, the ITPA genotypes may be a useful marker for prediction of RBV-induced anemia.

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February 2012
Volume 5 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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APA
Nishimura, T., Osaki, R., Shioya, M., Imaeda, H., Aomatsu, T., Takeuchi, T. ... Andoh, A. (2012). Polymorphism of the inosine triphosphate pyrophosphatase gene predicts ribavirin-induced anemia in chronic hepatitis C patients. Molecular Medicine Reports, 5, 517-520. https://doi.org/10.3892/mmr.2011.659
MLA
Nishimura, T., Osaki, R., Shioya, M., Imaeda, H., Aomatsu, T., Takeuchi, T., Okumura, Y., Fujiyama, Y., Andoh, A."Polymorphism of the inosine triphosphate pyrophosphatase gene predicts ribavirin-induced anemia in chronic hepatitis C patients". Molecular Medicine Reports 5.2 (2012): 517-520.
Chicago
Nishimura, T., Osaki, R., Shioya, M., Imaeda, H., Aomatsu, T., Takeuchi, T., Okumura, Y., Fujiyama, Y., Andoh, A."Polymorphism of the inosine triphosphate pyrophosphatase gene predicts ribavirin-induced anemia in chronic hepatitis C patients". Molecular Medicine Reports 5, no. 2 (2012): 517-520. https://doi.org/10.3892/mmr.2011.659