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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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February 2012 Volume 5 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats

  • Authors:
    • Neng Wang
    • Xinwen Min
    • Dongfeng Li
    • Peigen He
    • Libin Zhao

  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Dongfeng Hospital of Hubei Medical University, Shiyan, Hubei 442008, P.R. China
  • Pages: 521-524
    |
    Published online on: November 4, 2011
       https://doi.org/10.3892/mmr.2011.666
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Abstract

The high mobility group box 1 (HMGB1) protein plays an important role in myocardial ischemia and reperfusion (I/R) injury. Geranylgeranylacetone (GGA), a heat shock protein 72 inducer, has been reported to reduce myocardial I/R injury. The aim of this study was to investigate the cardioprotective mechanism of GGA during myocardial I/R injury in rats. Anesthetized male rats were treated once with GGA (200 mg/kg, p.o.) 24 h before ischemia, and subjected to ischemia for 30 min, followed by reperfusion for 4 h. Lactate dehydrogenase (LDH), creatine kinase (CK), malondialdehyde (MDA), superoxide dismutase (SOD) activity and infarct size were measured. HMGB1 expression was assessed by immunoblotting. The results showed that pre-treatment with GGA (200 mg/kg) significantly reduced the infarct size and the levels of LDH and CK after 4 h of reperfusion (all P<0.05). GGA also significantly inhibited the increase in MDA levels and the decrease in SOD levels (both P<0.05). Meanwhile, GGA considerably suppressed the expression of HMGB1 induced by I/R. The present study suggests that GGA is capable of attenuating myocardial I/R injury by inhibiting HMGB1 expression.

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Copy and paste a formatted citation
Spandidos Publications style
Wang N, Min X, Li D, He P and Zhao L: Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats. Mol Med Rep 5: 521-524, 2012.
APA
Wang, N., Min, X., Li, D., He, P., & Zhao, L. (2012). Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats. Molecular Medicine Reports, 5, 521-524. https://doi.org/10.3892/mmr.2011.666
MLA
Wang, N., Min, X., Li, D., He, P., Zhao, L."Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats". Molecular Medicine Reports 5.2 (2012): 521-524.
Chicago
Wang, N., Min, X., Li, D., He, P., Zhao, L."Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats". Molecular Medicine Reports 5, no. 2 (2012): 521-524. https://doi.org/10.3892/mmr.2011.666
Copy and paste a formatted citation
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Spandidos Publications style
Wang N, Min X, Li D, He P and Zhao L: Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats. Mol Med Rep 5: 521-524, 2012.
APA
Wang, N., Min, X., Li, D., He, P., & Zhao, L. (2012). Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats. Molecular Medicine Reports, 5, 521-524. https://doi.org/10.3892/mmr.2011.666
MLA
Wang, N., Min, X., Li, D., He, P., Zhao, L."Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats". Molecular Medicine Reports 5.2 (2012): 521-524.
Chicago
Wang, N., Min, X., Li, D., He, P., Zhao, L."Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by inhibiting high-mobility group box 1 protein in rats". Molecular Medicine Reports 5, no. 2 (2012): 521-524. https://doi.org/10.3892/mmr.2011.666
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