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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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February 2012 Volume 5 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Neuroprotection of desferrioxamine in lipopolysaccharide-induced nigrostriatal dopamine neuron degeneration

  • Authors:
    • Zhen Zhang
    • Keke Zhang
    • Xinrui Du
    • Yanbin Li

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, P.R. China, Department of Otorhinolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, P.R. China
  • Pages: 562-566
    |
    Published online on: November 9, 2011
       https://doi.org/10.3892/mmr.2011.671
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Abstract

Inflammation and iron accumulation in the substantia nigra (SN) are implicated in the pathogenesis of Parkinson's disease (PD). However, the relationship between neuroinflammation and iron mismanagement remain largely unknown. In the present study, an animal model induced by lipopolysaccharide (LPS) was used to evaluate iron concentration in the ventral midbrain with or without neuroinflammation. Furthermore, the iron chelator desferrioxamine (DFO) was used to explore its neuroprotective property against LPS-induced nigrostriatal degeneration. Adult C57BL/6 mice were treated with DFO (2.5 µg) commenced 3 days prior to or following microinjection of LPS into the striatum. Animal behavioral tests, as well as pathological and biochemical assays were performed to evaluate the nigrostriatal dopamine neuron degeneration and neuroprotective effects of DFO. Here, we report that the iron concentration in the ventral midbrain significantly increased following intrastriatal injection of LPS, and administration of DFO improved behavior deficits, attenuated dopamine (DA) neuron loss and striatal DA reduction, and alleviated microglial activation in the SN. These results suggest that DFO may possess neuroprotective effect against LPS-induced nigrostriatal dopamine neuron degeneration.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Zhang K, Du X and Li Y: Neuroprotection of desferrioxamine in lipopolysaccharide-induced nigrostriatal dopamine neuron degeneration. Mol Med Rep 5: 562-566, 2012.
APA
Zhang, Z., Zhang, K., Du, X., & Li, Y. (2012). Neuroprotection of desferrioxamine in lipopolysaccharide-induced nigrostriatal dopamine neuron degeneration. Molecular Medicine Reports, 5, 562-566. https://doi.org/10.3892/mmr.2011.671
MLA
Zhang, Z., Zhang, K., Du, X., Li, Y."Neuroprotection of desferrioxamine in lipopolysaccharide-induced nigrostriatal dopamine neuron degeneration". Molecular Medicine Reports 5.2 (2012): 562-566.
Chicago
Zhang, Z., Zhang, K., Du, X., Li, Y."Neuroprotection of desferrioxamine in lipopolysaccharide-induced nigrostriatal dopamine neuron degeneration". Molecular Medicine Reports 5, no. 2 (2012): 562-566. https://doi.org/10.3892/mmr.2011.671
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Zhang K, Du X and Li Y: Neuroprotection of desferrioxamine in lipopolysaccharide-induced nigrostriatal dopamine neuron degeneration. Mol Med Rep 5: 562-566, 2012.
APA
Zhang, Z., Zhang, K., Du, X., & Li, Y. (2012). Neuroprotection of desferrioxamine in lipopolysaccharide-induced nigrostriatal dopamine neuron degeneration. Molecular Medicine Reports, 5, 562-566. https://doi.org/10.3892/mmr.2011.671
MLA
Zhang, Z., Zhang, K., Du, X., Li, Y."Neuroprotection of desferrioxamine in lipopolysaccharide-induced nigrostriatal dopamine neuron degeneration". Molecular Medicine Reports 5.2 (2012): 562-566.
Chicago
Zhang, Z., Zhang, K., Du, X., Li, Y."Neuroprotection of desferrioxamine in lipopolysaccharide-induced nigrostriatal dopamine neuron degeneration". Molecular Medicine Reports 5, no. 2 (2012): 562-566. https://doi.org/10.3892/mmr.2011.671
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