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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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February 2012 Volume 5 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Regulation of rat MOR-1 gene expression after chronic intracerebroventricular administration of morphine

  • Authors:
    • Zhi-Ping Zhu
    • Ramesh B. Badisa
    • Donald E. Palm
    • Carl B. Goodman

  • View Affiliations / Copyright

    Affiliations: College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
  • Pages: 513-516
    |
    Published online on: November 15, 2011
       https://doi.org/10.3892/mmr.2011.677
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Abstract

The µ-opioid receptor is the primary site for the action of morphine. In the present study, we investigated the regulation of the µ-opioid receptor mRNA levels in the locus ceruleus, ventral tegmental area, nucleus accumbens and hypothalamus of the rat brain following intracerebroventricular administration of morphine for 7 days. The isolated mRNA from these regions was subjected to real-time quantitative RT-PCR to determine the regulation of µ-opioid receptor gene expression. It was observed that 7 days of treatment with morphine significantly down-regulated the µ-opioid receptor mRNA levels in the hypothalamus of the brain in comparison to the control group. However, the µ-opioid receptor levels in the locus ceruleus, ventral tegmental area and nucleus accumbens regions remained the same as the control levels. Down-regulation of µ-opioid receptor mRNA levels in the hypothalamus region of the brain indicates the probable role of opioids to influence neuroendocrine function. The results further indicate that cellular adaptation for morphine tolerance is tissue‑specific. These findings help us to understand the mechanism of morphine tolerance in various regions of the brain.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu Z, Badisa RB, Palm DE and Goodman CB: Regulation of rat MOR-1 gene expression after chronic intracerebroventricular administration of morphine. Mol Med Rep 5: 513-516, 2012.
APA
Zhu, Z., Badisa, R.B., Palm, D.E., & Goodman, C.B. (2012). Regulation of rat MOR-1 gene expression after chronic intracerebroventricular administration of morphine. Molecular Medicine Reports, 5, 513-516. https://doi.org/10.3892/mmr.2011.677
MLA
Zhu, Z., Badisa, R. B., Palm, D. E., Goodman, C. B."Regulation of rat MOR-1 gene expression after chronic intracerebroventricular administration of morphine". Molecular Medicine Reports 5.2 (2012): 513-516.
Chicago
Zhu, Z., Badisa, R. B., Palm, D. E., Goodman, C. B."Regulation of rat MOR-1 gene expression after chronic intracerebroventricular administration of morphine". Molecular Medicine Reports 5, no. 2 (2012): 513-516. https://doi.org/10.3892/mmr.2011.677
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Z, Badisa RB, Palm DE and Goodman CB: Regulation of rat MOR-1 gene expression after chronic intracerebroventricular administration of morphine. Mol Med Rep 5: 513-516, 2012.
APA
Zhu, Z., Badisa, R.B., Palm, D.E., & Goodman, C.B. (2012). Regulation of rat MOR-1 gene expression after chronic intracerebroventricular administration of morphine. Molecular Medicine Reports, 5, 513-516. https://doi.org/10.3892/mmr.2011.677
MLA
Zhu, Z., Badisa, R. B., Palm, D. E., Goodman, C. B."Regulation of rat MOR-1 gene expression after chronic intracerebroventricular administration of morphine". Molecular Medicine Reports 5.2 (2012): 513-516.
Chicago
Zhu, Z., Badisa, R. B., Palm, D. E., Goodman, C. B."Regulation of rat MOR-1 gene expression after chronic intracerebroventricular administration of morphine". Molecular Medicine Reports 5, no. 2 (2012): 513-516. https://doi.org/10.3892/mmr.2011.677
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